Enability: How Architecture Can Enable the Disabled

Enability is designing with empathy from the very beginning of a design. It incorporates design strategies for a variety of disabilities, as well as tackling the difficulties that are known to disproportionately affect those with disabilities, such as employment and access to childcare. It features a community center, located in Rochester, Minnesota, that incorporates a full restaurant and childcare center with the goal of providing both services as well as employment opportunities for individuals with disabilities in the area. By considering as many aspects as possible it is hoped that this community center can be an example of how architects can move beyond the ADA requirements and choose to truly reimagine how the disability experience is transformed through their designs

“No One Can Serve Two Masters”: A Separation of Powers Solution for Conflicts of Interest Within the Department of Health and Human Services

This Comment examines the financial conflicts of interests within the DHHS that results in private influence, the consequential impact of the private influence on the agency\u27s constitutionality under the nondelegation and separation of powers doctrines, and offers a solution that better conforms to the principles and structure of the United States Constitution. Part II examines the penetration of conflicts of interests within the DHHS and impact on drug safety and human lives. Part III discusses the separation of powers doctrine and the development of the nondelegation doctrine with respect to delegations to private groups. Part IV analyzes the constitutionality of administrative agencies under the influence of private interests. Part V analyzes the constitutionality of administrative agencies with respect to the separation of powers doctrine. Part VI proposes a solution to the problems of private interests with administrative agencies. This Comment concludes in advocating a long term solution of repairing the structural flaws that violate the separation of powers by advocating the reformation of Executive Branch agencies into constituent legislative, executive and adjudicatory functions and altering their reporting structure to corresponding branches. In practical terms, the agencies must be disassembled and rebuilt to separate the powers

The Influence of Problem-Based Learning on Drawing Ability

Learning skill in visual arts has been positively associated with problem-based-learning (PBL). Although researchers theorize that PBL engages students to increase learning, many visual arts instructors continue to use skill-based learning (SBL) in their classrooms.https://scholarworks.waldenu.edu/archivedposters/1081/thumbnail.jp

Modeling the cognitive effects of diet discontinuation in adults with phenylketonuria (PKU) using pegvaliase therapy in PAH-deficient mice

Existing phenylalanine hydroxylase (PAH)-deficient mice strains are useful models of untreated or late-treated human phenylketonuria (PKU), as most contemporary therapies can only be initiated after weaning and the pups have already suffered irreversible consequences of chronic hyperphenylalaninemia (HPA) during early brain development. Therefore, we sought to evaluate whether enzyme substitution therapy with pegvaliase initiated near birth and administered repetitively to C57Bl/6-Pahenu2/enu2 mice would prevent HPA-related behavioral and cognitive deficits and form a model for early-treated PKU. The main results of three reported experiments are: 1) lifelong weekly pegvaliase treatment prevented the cognitive deficits associated with HPA in contrast to persisting deficits in mice treated with pegvaliase only as adults. 2) Cognitive deficits reappear in mice treated with weekly pegvaliase from birth but in which pegvaliase is discontinued at 3 months age. 3) Twice weekly pegvaliase injection also prevented cognitive deficits but again cognitive deficits emerged in early-treated animals following discontinuation of pegvaliase treatment during adulthood, particularly in females. In all studies, pegvaliase treatment was associated with complete correction of brain monoamine neurotransmitter content and with improved overall growth of the mice as measured by body weight. Mean total brain weight however remained low in all PAH deficient mice regardless of treatment. Application of enzyme substitution therapy with pegvaliase, initiated near birth and continued into adulthood, to PAH-deficient Pahenu2/enu2 mice models contemporary early-treated human PKU. This model will be useful for exploring the differential pathophysiologic effects of HPA at different developmental stages of the murine brain. Keywords: Behavior; Cognition; Dopamine; Hyperphenylalaninemia; Pegvaliase; Phenylalanine hydroxylase; Phenylketonuria; Serotonin; Tryptophan; Tryptophan hydroxylase; Tyrosine; Tyrosine hydroxylase

Beam-forming module for backhaul link in a Relay-aided 4G network

YesA novel beam-forming module based on Wilkinson power divider technology, including attenuators and phase shifter chips is designed, fabricated and evaluated to be incorporated in a Relay Station connecting it with the Base Station under a 4G network. The proposed module is a 1:8 port circuit, utilizing two substrates, providing approximately 700 MHz bandwidth over 3.5 GHz frequency band and less than −20 dB transmission line coupling. Moreover an external control unit that feeds the beam-forming module with code-words that define the proper amplitude/phase of the excitation currents is established and described. The presented module is connected to a planar array and tested for two beam-forming scenarios, providing satisfactory radiation patterns

“No One Can Serve Two Masters”: A Separation of Powers Solution for Conflicts of Interest Within the Department of Health and Human Services

This Comment examines the financial conflicts of interests within the DHHS that results in private influence, the consequential impact of the private influence on the agency\u27s constitutionality under the nondelegation and separation of powers doctrines, and offers a solution that better conforms to the principles and structure of the United States Constitution. Part II examines the penetration of conflicts of interests within the DHHS and impact on drug safety and human lives. Part III discusses the separation of powers doctrine and the development of the nondelegation doctrine with respect to delegations to private groups. Part IV analyzes the constitutionality of administrative agencies under the influence of private interests. Part V analyzes the constitutionality of administrative agencies with respect to the separation of powers doctrine. Part VI proposes a solution to the problems of private interests with administrative agencies. This Comment concludes in advocating a long term solution of repairing the structural flaws that violate the separation of powers by advocating the reformation of Executive Branch agencies into constituent legislative, executive and adjudicatory functions and altering their reporting structure to corresponding branches. In practical terms, the agencies must be disassembled and rebuilt to separate the powers

Wing In Ground Effect - A New Approach For The Human Powered Helicopter

In this paper a brief overview of the human powered flight will be given at the beginning. The power demand of the most successful human powered fixed wing aircraft will be shown in order to point out the available power problems concerning the design of the rotary wing aircraft. The human ability to perform physical work and therein involved metabolic mechanisms will be shown with their limitations and problems in the accessibility for reliable human power expectations. Furthermore it is not possible to predict the duration of the increased power setting following the constant performance duration. The presentation of analytical calculation method of simplified helicoid will serve as an introduction to the main problem of human powered helicopters – the limited human power source. The invalidity of the common in ground effect models for the purpose of power demand estimation and modest success of realized human powered helicopter designs lead to the alternative approach – the wing in ground effect – as the most promising idea

A MULTIDISCIPLINARY TOOLBOX FOR ROTORCRAFT DESIGN

The German Aerospace Center (DLR) is currently developing a multidisciplinary toolbox for the design of conventional and unconventional rotorcraft. The resulting design process will be the result of the DLR-internal project EDEN (Evaluation and DEsign of Novel rotorcraft concepts), which is a joint study between the Institute of Flight Systems, the Institute of Aerodynamics and Flow Technology and the Institute of Structures and Design. The complexity of rotorcraft design requires the development of the tools directly by the specialists of the respective institutes, where the tools are continuously refined and published to authorized users. The integration of the tools into a suitable software framework and the harmonization of the tools among each other are presented. This framework delivers a high level of modularity making the layout and testing of the process very flexible. The implemented tools cover the conceptual and preliminary design phases. The design process starts with an empty workspace and the minimum input of payload mass, range, cruise speed, number of rotor blades and a rotor configuration. Not only conventional main/tail rotor configurations can be designed, but also some other configurations with more than one main rotor. The fundamental concept behind the layout of the tools inside the process is demonstrated, especially the use of scaling and optimization loops. The process includes statistical methods to initialize the dataset, methods with more sophisticated physical models for the scaling task and finite element methods for the best possible prediction of the structural properties quite early in the design process

Statistische Verfahren zur Abschätzung elementarer Designparameter im Hubschraubervorentwurf

Der vorliegende Bericht stellt ein integriertes, statistisch basiertes Werkzeug zum Hubschraubervorentwurf vor und beleuchtet dabei zwei Aspekte der Thematik. Zum einen werden Abhängigkeiten zwischen Parametern von existenten Hubschraubermustern mittels Hauptkomponenten- und Korrelationsanalyse untersucht. Daraus lässt sich ableiten, inwiefern flugmechanisch motivierte Eingangsgrößen für eine statistische Auswertung geeignet sind. Des Weiteren wird ein multivariates Regressionsverfahren erörtert, mit dem eine Abschätzung wesentlicher Entwurfsparameter möglich ist. Im Gegensatz zu den meisten bisherigen Untersuchungen wurden hier Polynomansätze höherer Ordnung verwendet und mehrere statistische Methoden miteinander kombiniert, sodass eine automatische Reduktion der Komplexität der Regressionsfunktionen ermöglicht wird. Das entwickelte Werkzeug ist universell, auch außerhalb des Hubschraubervorentwurfs anwendbar