21 research outputs found
HELP apheresis in hypercholesterolemia and cardiovascular disease: efficacy and adverse events after 8,500 procedures
Direct observation of reaction intermediates for a well defined heterogeneous alkene metathesis catalyst
Grafting of [W(≡NAr)(=CHtBu)(2,5-Me2NC4H2)2] on a silica partially dehydroxylated at 700°C (SiO2- (700)) generates the corresponding monosiloxy complex [(≡SiO)W(≡NAr)(=CHtBu)(2,5-Me2NC4H2)] as the major species (≈90%) along with [(≡SiO)W(≡NAr)(CH2tBu)(2,5-Me2NC4H2)2], according to mass balance analysis, IR, and NMR studies. This heterogeneous catalyst displays good activity and stability in the metathesis of propene. Very importantly, solid state NMR spectroscopy allows observation of the propagating alkylidene as well as stable metallacyclobutane intermediates. These species have the same reactivity as the initial surface complex [(≡SiO)W(≡NAr)(=CHtBu)(2,5-Me2NC4H2)], which shows that they are the key intermediates of alkene metathesis
Synthesis of Molybdenum and Tungsten Alkylidene Complexes That Contain Sterically Demanding Arenethiolate Ligands
Imido alkylidene complexes of Mo
and W and oxo alkylidene complexes
of W that contain thiophenoxide ligands of the type S-2,3,5,6-Ph<sub>4</sub>C<sub>6</sub>H (STPP) and S-2,6-(mesityl)<sub>2</sub>C<sub>6</sub>H<sub>3</sub> (SHMT = S-hexamethylterphenyl) have been prepared
in order to compare their metathesis activity with that of the analogous
phenoxide complexes. All thiolate complexes were significantly slower
(up to ∼10× slower) for the metathesis homocoupling of
1-octene or polymerization of 2,3-dicarbomethoxynorbornene, and none
of them was <i>Z</i>-selective. The slower rates could be
attributed to the greater σ-donating ability of a thiophenoxide
versus the analogous phenoxide and consequently a higher electron
density at the metal in the thiophenoxide complexes