A new method to suppress the bias in polarized intensity

Computing polarised intensities from noisy data in Stokes U and Q suffers from a positive bias that should be suppressed. To develop a correction method that, when applied to maps, should provide a distribution of polarised intensity that closely follows the signal from the source. We propose a new method to suppress the bias by estimating the polarisation angle of the source signal in a noisy environment with help of a modified median filter. We then determine the polarised intensity, including the noise, by projection of the observed values of Stokes U and Q onto the direction of this polarisation angle. We show that our new method represents the true signal very well. If the noise distribution in the maps of U and Q is Gaussian, then in the corrected map of polarised intensity it is also Gaussian. Smoothing to larger Gaussian beamsizes, to improve the signal-to-noise ratio, can be done directly with our method in the map of the polarised intensity. Our method also works in case of non-Gaussian noise distributions. The maps of the corrected polarised intensities and polarisation angles are reliable even in regions with weak signals and provide integrated flux densities and degrees of polarisation without the cumulative effect of the bias, which especially affects faint sources. Features at low intensity levels like 'depolarisation canals' are smoother than in the maps using the previous methods, which has broader implications, for example on the interpretation of interstellar turbulence.Comment: accepted for publication in Astronomy & Astrophysic

The NOD3 software package: A graphical user interface-supported reduction package for single-dish radio continuum and polarisation observations

The venerable NOD2 data reduction software package for single-dish radio continuum observations, developed for use at the 100-m Effelsberg radio telescope, has been successfully applied over many decades. Modern computing facilities call for a new design. We aim to develop an interactive software tool with a graphical user interface (GUI) for the reduction of single-dish radio continuum maps. Special effort is given on the reduction of distortions along the scanning direction (scanning effects) by combining maps scanned in orthogonal directions or dual- or multiple-horn observations that need to be processed in a restoration procedure. The package should also process polarisation data and offer the possibility to include special tasks written by the individual user. Based on the ideas of the NOD2 package we developed NOD3, which includes all necessary tasks from the raw maps to the final maps in total intensity and linear polarisation. Furthermore, plot routines and several methods for map analysis are available. The NOD3 package is written in Python which allows to extend the package by additional tasks. The required data format for the input maps is FITS. NOD3 is a sophisticated tool to process and analyse maps from single-dish observations that are affected by 'scanning effects' due to clouds, receiver instabilities, or radio-frequency interference (RFI). The 'basket-weaving' tool combines orthogonally scanned maps to a final map that is almost free of scanning effects. The new restoration tool for dual-beam observations reduces the noise by a factor of about two compared to the NOD2 version. Combining single-dish with interferometer data in the map plane ensures the full recovery of the total flux density.Comment: 8 pages, 10 figures, Accepted for publication in A&

Neuroinflammation, Microglia and Implications for Anti-Inflammatory Treatment in Alzheimer's Disease

Neuroinflammation has been implicated in the pathology of Alzheimer's disease (AD) for decades. Still it has not been fully understood when and how inflammation arises in the course of AD. Whether inflammation is an underling cause or a resulting condition in AD remains unresolved. Mounting evidence indicates that microglial activation contributes to neuronal damage in neurodegenerative diseases. However, also beneficial aspects of microglial activation have been identified. The purpose of this review is to highlight new insights into the detrimental and beneficial role of neuroinflammation in AD. It is our intention to focus on newer controversies in the field of microglia activation. Precisely, we want to shed light on whether neuroinflammation is associated to brain tissue damage and functional impairment or is there also a damage limiting activity. In regard to this, we discuss the limitations and the advantages of anti-inflammatory treatment options and identify what future implications might result from this underling neuroinflammation for AD therapy

Soft Dynamic Time Warping for Multi-Pitch Estimation and Beyond

Many tasks in music information retrieval (MIR) involve weakly aligned data, where exact temporal correspondences are unknown. The connectionist temporal classification (CTC) loss is a standard technique to learn feature representations based on weakly aligned training data. However, CTC is limited to discrete-valued target sequences and can be difficult to extend to multi-label problems. In this article, we show how soft dynamic time warping (SoftDTW), a differentiable variant of classical DTW, can be used as an alternative to CTC. Using multi-pitch estimation as an example scenario, we show that SoftDTW yields results on par with a state-of-the-art multi-label extension of CTC. In addition to being more elegant in terms of its algorithmic formulation, SoftDTW naturally extends to real-valued target sequences.Comment: Accepted at ICASSP 202