Advanced nickel-cadmium batteries for geosynchronous spacecraft

A nickel cadmium battery was developed that can be operated at 80 percent depth of discharge in excess of 10 years in a geosynchronous orbit application, and has about a 30 percent weight savings per spacecraft over present nickel cadmium batteries when used with a 1000 watts eclipse load. The approach used in the development was to replace nylon separators with inert polymer impregnated zirconia, use electrochemically deposited plates in place of conventional chemically precipitated ones, and use an additive to extend negative plate lifetime. The design has undergone extensive testing using both engineering and protoflight cell configurations

Near-Optimal Multi-Perturbation Experimental Design for Causal Structure Learning

Causal structure learning is a key problem in many domains. Causal structures can be learnt by performing experiments on the system of interest. We address the largely unexplored problem of designing a batch of experiments that each simultaneously intervene on multiple variables. While potentially more informative than the commonly considered single-variable interventions, selecting such interventions is algorithmically much more challenging, due to the doubly-exponential combinatorial search space over sets of composite interventions. In this paper, we develop efficient algorithms for optimizing different objective functions quantifying the informativeness of a budget-constrained batch of experiments. By establishing novel submodularity properties of these objectives, we provide approximation guarantees for our algorithms. Our algorithms empirically perform superior to both random interventions and algorithms that only select single-variable interventions.Comment: 10 pages, 2 figures, appendix, to be published in 35th Conference on Neural Information Processing Systems (NeurIPS 2021), fixed typos and clarified wordin

Multituberculates (Mammalia, Allotheria) From The Earliest Tiffanian (Late Paleocene) Douglass Quarry, Eastern Crazy Mountains Basin, Montana

http://deepblue.lib.umich.edu/bitstream/2027.42/49355/1/Vol 31 No10 final 11-15-06.pd

Model-based Causal Bayesian Optimization

How should we intervene on an unknown structural equation model to maximize a downstream variable of interest? This setting, also known as causal Bayesian optimization (CBO), has important applications in medicine, ecology, and manufacturing. Standard Bayesian optimization algorithms fail to effectively leverage the underlying causal structure. Existing CBO approaches assume noiseless measurements and do not come with guarantees. We propose the model-based causal Bayesian optimization algorithm (MCBO) that learns a full system model instead of only modeling intervention-reward pairs. MCBO propagates epistemic uncertainty about the causal mechanisms through the graph and trades off exploration and exploitation via the optimism principle. We bound its cumulative regret, and obtain the first non-asymptotic bounds for CBO. Unlike in standard Bayesian optimization, our acquisition function cannot be evaluated in closed form, so we show how the reparameterization trick can be used to apply gradient-based optimizers. The resulting practical implementation of MCBO compares favorably with state-of-the-art approaches empirically.Comment: 24 pages, 8 figures, accepted at ICLR 202

Outpost of Freedom: A German-American Network’s Campaign to bring Cold War Democracy to West Berlin, 1933-66

This study explores Berlin’s sudden transformation from the capital of Nazi Germany to bastion of democracy in the Cold War. This project has unearthed how this remarkable development resulted from a transatlantic campaign by liberal American occupation officials, and returned émigrés, or remigrés, of the Marxist Social Democratic Party (SPD). This informal network derived from members of “Neu Beginnen” in American exile. Concentrated in wartime Manhattan, their identity as German socialists remained remarkably durable despite the Nazi persecution they faced and their often-Jewish background. Through their experiences in New Deal America, these self-professed “revolutionary socialists” came to emphasize “anti-totalitarianism,” making them suspicious of Stalinism. Serving in the OSS, leftists such as Hans Hirschfeld forged friendships with American left-wing liberals. These experiences connected a wider network of remigrés and occupiers by forming an epistemic community in postwar Berlin. They recast Berlin’s ruins as “Outpost of Freedom” in the Cold War. Popularizing this narrative through access to the vast resources of American foreign policy and control of the city’s dominant party and radio RIAS made Ernst Reuter and Willy Brandt especially effective Mayors. Archival research uncovered how personal experiences in exile prefigured this surprising alliance between reformers of the SPD and US occupation officials within OMGUS and HICOG. By connecting the network that redefined West Berlin with its roots in wartime Manhattan, this study provides a new, transnational explanation for the alignment of Germany’s principal left-wing party with the Western camp in the Cold War. By unearthing substantial, yet covert American contributions, my research outlines how this network shaped an anti-Communist political left in postwar Germany. While standard accounts portray Berlin as a stage of Cold War dramatics, my research highlights how the city’s urban politics pioneered seminal developments in the Federal Republic of Germany, rendering it an alternative to the West German brand of democratization. For instance, the remigrés anticipated the national SPD’s 1959 turn that scrapped Marxist theory and endorsed NATO membership. Moreover, this network groomed Brandt for the Chancellorship, illustrating a route between the margins of exile and West Germany’s most prominent posts.Doctor of Philosoph

Trends and Seasonality of Emergency Department Visits and Hospitalizations For Suicidality among Children and adolescents in the Us From 2016 to 2021

IMPORTANCE: The detection of seasonal patterns in suicidality should be of interest to clinicians and US public health officials, as intervention efforts can benefit by targeting periods of heightened risk. OBJECTIVES: to examine recent trends in suicidality rates, quantify the seasonality in suicidality, and demonstrate the disrupted seasonality patterns during the spring 2020 COVID-19-related school closures among US children and adolescents. DESIGN, SETTING, AND PARTICIPANTS: This population-based, descriptive cross-sectional study used administrative claims data from Optum\u27s deidentifed Clinformatics Data Mart Database. Participants included children aged 10 to 12 years and adolescents aged 13 to 18 years who were commercially insured from January 1, 2016, to December 31, 2021. Statistical analysis was conducted between April and November 2022. EXPOSURES: Month of the year and COVID-19 pandemic. MAIN OUTCOMES AND MEASURES: Rates and seasonal patterns of emergency department (ED) visits and hospitalizations for suicidality. RESULTS: The analysis included 73 123 ED visits and hospitalizations for suicidality reported between 2016 and 2021. Among these events, 66.1% were reported for females, and the mean (SD) age at the time of the event was 15.4 (2.0) years. The mean annual incidence of ED visits and hospitalizations for suicidality was 964 per 100 000 children and adolescents (95% CI, 956-972 per 100 000), which increased from 760 per 100 000 (95% CI, 745-775 per 100 000) in 2016 to 1006 per 100 000 (95% CI, 988-10 024 per 100 000) in 2019, with a temporary decrease to 942 per 100 000 (95% CI, 924-960 per 100 000) in 2020 and a subsequent increase to 1160 per 100 000 (95% CI, 1140-1181 per 100 000) in 2021. Compared with January, seasonal patterns showed peaks in April (incidence rate ratio [IRR], 1.15 [95% CI, 1.11-1.19]) and October (IRR, 1.24 [95% CI, 1.19-1.29]) and a nadir in July (IRR, 0.63 [95% CI, 0.61-0.66]) during pre-COVID-19 years and 2021. However, during the spring of 2020, which coincided with school closures, seasonal patterns were disrupted and April and May exhibited the lowest rates. CONCLUSIONS AND RELEVANCE: The findings of this study indicated the presence of seasonal patterns and an observed unexpected decrease in suicidality among children and adolescents after COVID-19-related school closures in March 2020, which suggest a potential association between suicidality and the school calendar

Impact of medical, health related, social and occupational factors on post-liver transplant recovery: a longitudinal study

poster abstractPurpose: Organ transplantation is a serious surgery with nearly 10% of patients failing to survive the first three months. Studies of quality of life reflect an increase post-transplant, as compared to pre-transplant, then reports vary including a trend towards decreasing QOL scores by the end of the first transplanted year. In this first year, patients have an increased risk of re-hospitalization due to infection, failure of the body to accept the graft, problems with anti-rejection medications or post- surgical complications. Methods: A longitudinal study of liver transplant recipients (n=23) followed medical, social, and occupational factors, along with SF-36 measures. Results: Variability in QOL scores at 1, 2, 3, 6, 9, and 12 months were directly related to identifiable factors. In those subjects where health returned in an uncomplicated manner, QOL scores consistently improved with the greatest change occurring over the first six months and then tapering off through the end of the first year. Conclusions: These subjects almost uniformly expressed frustration at the length of time it took to return to a healthy state. In circumstances where recovery was delayed due to medical reasons, QOL scores declined significantly until the problems were resolved. In several cases, QOL scores stayed low as these individuals were unprepared for the potential complications associated with this difficult surgery

Fatigue as Reported at 12 Time Points during the First Year Post-Liver Transplant

abstractBACKGROUND: Although liver transplantation has evolved as an effective procedure, fatigue remains a post-transplant complaint [1]. As yet, there are no published accounts of the experience of fatigue at temporal intervals during the first post-transplant year, and this information would benefit LT candidates in recovery planning. Van Ginneken [2] found that time since transplant was not associated with physical fatigue and reduced activity, but was associated with albumin levels less than 25g/l and with lower GFR. METHODS: Data used in this study were collected through an ongoing, longitudinal, prospective design. Results presented here are for fatigue and biometric data at 12 data points starting one week post hospital discharge, continued weekly for the first 8 weeks, then monthly at 3, 6, 9, and 12 months. RESULTS: We sampled 30 subjects: 19 (70.4%) male and 8 (29.6%) female, age 55.4 ± 9.8 years. A mixed models analysis of variance was done to investigate a change in FACIT over time. The initial model included age, MELD, sex, week, albumin, ALT, BILI T, and CREAT. The final model included age, BILI T, and week. Increasing age and BILI T were associated with greater fatigue (p=0.0376 and p=0.0005, respectively). There was significant decrease in fatigue over time (p<0.0001). Pair-wise comparisons were done to determine which weeks significantly differed. Tukey’s adjustment for multiple comparisons was used. Figure 1 indicates which visits significantly differed. DISCUSSION: Our subjects experienced decreased fatigue over time. The data set was rich with prospectively collected longitudinal information helpful for establishing realistic expectations for post-transplant fatigue. Finding include early weeks of recovery (weeks 2-3) differ from weeks 7+ and that there is no significant change after 3 months, up to one year. No association was seen with Albumin levels although total bilirubin and age were associated with greater fatigue