167 research outputs found
Catalytic Asymmetric 1,6-Michael Addition of Arylthiols to 3-Methyl-4-nitro-5-alkenyl-isoxazoles with Bifunctional Catalysts
Synthesis of cis,cis-4,8-dimethyl-cis-2-oxa-6-oxodecahydroazulene. A precursor in an attempted synthesis of .beta.-vetivone
VisibleâLightâEnabled Synthesis of Pyridyl Benzamides via Oxidative Decarbethoxylation using Copper(I) Iodide/Air at Room Temperature
Preparation of Amidine Salts by Reaction of Nitriles with Ammonium Salts in the Presence of Ammonia
The Mechanism of Formation of the Sodium Salt of Tetraethylpropene-1,1,3,3-tetracarboxylate during the Reaction of Dichlorocarbene with the Sodium Salt of Diethyl Malonate
Effect of G-quadruplex polymorphism on the recognition of telomeric DNA by a metal complex
The physiological role(s) played by G-quadruplexes renders these 'non-canonical' DNA secondary structures interesting new targets for therapeutic intervention. In particular, the search for ligands for selective recognition and stabilization of G-quadruplex arrangements has led to a number of novel targeted agents. An interesting approach is represented by the use of metal-complexes, their binding to DNA being modulated by ligand and metal ion nature, and by complex stoichiometry. In this work we characterized thermodynamically and stereochemically the interactions of a Ni(II) bis-phenanthroline derivative with telomeric G-quadruplex sequences using calorimetric, chiroptical and NMR techniques. We employed three strictly related sequences based on the human telomeric repeat, namely Tel22, Tel26 and wtTel26, which assume distinct conformations in potassium containing solutions. We were able to monitor specific enthalpy/entropy changes according to the structural features of the target telomeric sequence and to dissect the binding process into distinct events. Interestingly, temperature effects turned out to be prominent both in terms of binding stoichiometry and \u394H/\u394S contributions, while the final G-quadruplex-metal complex architecture tended to merge for the examined sequences. These results underline the critical choice of experimental conditions and DNA sequence for practical use of thermodynamic data in the rational development of effective G-quadruplex binders
Synthesis and antitumor evaluations of 1, 8-bis[(2-aminoethyl) amino]anthracene-9,10-diones
Bull.Chem.Soc.Ethiop.,2(2), 69-72 (1988)
Differential binding mode of a phenanthroline-base metal complex to a DNA or RNA telomeric sequence
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