Low cost silicon solar arrays

Continuous growth methodology for silicon solar cell ribbons deals with capillary effects, die effects, thermal effects and crystal shape effects. Emphasis centers on the shape of the meniscus at the ribbon edge as a factor contributing to ribbon quality with respect to defect densities. Structural and electrical characteristics of edge defined, film-fed grown silicon ribbons are elaborated. Ribbon crystal solar cells produce AMO efficiencies of 6 to 10%

The stellar content of 10 dwarf irregular galaxies

We examine the stellar content of 10 dwarf irregular galaxies of which broad-band CCD photometry was published in Hopp & Schulte-Ladbeck (1995). We also present Halpha images for several of these galaxies. The galaxies in the sample are located outside of the Local Group. Yet, they are still close enough to be resolved into single stars from the ground but only the brightest stars (or star clusters) are detected and there is severe crowding. The sample galaxies were selected to be isolated from massive neighbors; about half of them are (mostly peripheral) members of groups, the other half is located in the field. We discuss the vicinity of the sample galaxies to other dwarf galaxies. In order to interpret single-star photometry and draw conclusions about the stellar content or other distance-dependent quantities, it is crucial that accurate distances to the galaxies be known. The distances to the sample galaxies are not well known since all but one have not had a primary distance indicator measured. We make an attempt to constrain the distances by identifying the envelope of the brightest supergiants in B, B-R and R, B-R color-magnitude diagrams, but the results are not very accurate (we estimate the minimal error on the distance modulus is 1.36 mag). Nevertheless, the fact that the sample galaxies are resolved with direct ground-based imaging indicates that they are sufficiently nearby to represent good candidates for observations with instruments that provide high spatial resolution, e.g., adaptive optics systems on large ground-based telescopes, or the Hubble Space Telescope. ...Comment: 56 pages, 4 tables, 35 figures, The Astronomical Journal, accepte

HIV-1 Infection in Cyprus, the Eastern Mediterranean European Frontier: A Densely Sampled Transmission Dynamics Analysis from 1986 to 2012

Since HIV-1 treatment is increasingly considered an effective preventionstrategy, it is important to study local HIV-1 epidemics to formulate tailored preventionpolicies. The prevalence of HIV-1 in Cyprus was historically low until 2005. To investigatethe shift in epidemiological trends, we studied the transmission dynamics of HIV-1 in Cyprususing a densely sampled Cypriot HIV-1 transmission cohort that included 85 percent ofHIV-1-infected individuals linked to clinical care between 1986 and 2012 based on detailedclinical, epidemiological, behavioral and HIV-1 genetic information. Subtyping andtransmission cluster reconstruction were performed using maximum likelihood and Bayesianmethods, and the transmission chain network was linked to the clinical, epidemiological andbehavioral data. The results reveal that for the main HIV-1 subtype A1 and B sub-epidemics,young and drug-naïve HIV-1-infected individuals in Cyprus are driving the dynamics of thelocal HIV-1 epidemic. The results of this study provide a better understanding of thedynamics of the HIV-1 infection in Cyprus, which may impact the development of preventionstrategies. Furthermore, this methodology for analyzing densely sampled transmissiondynamics is applicable to other geographic regions to implement effective HIV-1 preventionstrategies in local settings

HIV-1 Infection in Cyprus, the Eastern Mediterranean European Frontier: A Densely Sampled Transmission Dynamics Analysis from 1986 to 2012

Since HIV-1 treatment is increasingly considered an effective preventionstrategy, it is important to study local HIV-1 epidemics to formulate tailored preventionpolicies. The prevalence of HIV-1 in Cyprus was historically low until 2005. To investigatethe shift in epidemiological trends, we studied the transmission dynamics of HIV-1 in Cyprususing a densely sampled Cypriot HIV-1 transmission cohort that included 85 percent ofHIV-1-infected individuals linked to clinical care between 1986 and 2012 based on detailedclinical, epidemiological, behavioral and HIV-1 genetic information. Subtyping andtransmission cluster reconstruction were performed using maximum likelihood and Bayesianmethods, and the transmission chain network was linked to the clinical, epidemiological andbehavioral data. The results reveal that for the main HIV-1 subtype A1 and B sub-epidemics,young and drug-naïve HIV-1-infected individuals in Cyprus are driving the dynamics of thelocal HIV-1 epidemic. The results of this study provide a better understanding of thedynamics of the HIV-1 infection in Cyprus, which may impact the development of preventionstrategies. Furthermore, this methodology for analyzing densely sampled transmissiondynamics is applicable to other geographic regions to implement effective HIV-1 preventionstrategies in local settings

HIV-1 Infection in Cyprus, the Eastern Mediterranean European Frontier: A Densely Sampled Transmission Dynamics Analysis from 1986 to 2012

Since HIV-1 treatment is increasingly considered an effective preventionstrategy, it is important to study local HIV-1 epidemics to formulate tailored preventionpolicies. The prevalence of HIV-1 in Cyprus was historically low until 2005. To investigatethe shift in epidemiological trends, we studied the transmission dynamics of HIV-1 in Cyprususing a densely sampled Cypriot HIV-1 transmission cohort that included 85 percent ofHIV-1-infected individuals linked to clinical care between 1986 and 2012 based on detailedclinical, epidemiological, behavioral and HIV-1 genetic information. Subtyping andtransmission cluster reconstruction were performed using maximum likelihood and Bayesianmethods, and the transmission chain network was linked to the clinical, epidemiological andbehavioral data. The results reveal that for the main HIV-1 subtype A1 and B sub-epidemics,young and drug-naïve HIV-1-infected individuals in Cyprus are driving the dynamics of thelocal HIV-1 epidemic. The results of this study provide a better understanding of thedynamics of the HIV-1 infection in Cyprus, which may impact the development of preventionstrategies. Furthermore, this methodology for analyzing densely sampled transmissiondynamics is applicable to other geographic regions to implement effective HIV-1 preventionstrategies in local settings

The concordance of the limiting antigen and the Bio-Rad avidity assays in persons from Estonia infected mainly with HIV-1 CRF06_cpx

BACKGROUND: Serological assays to determine HIV incidence have contributed to estimates of HIV incidence, monitoring of HIV spread, and evaluation of prevention strategies. Two frequently used incidence assays are the Sedia HIV-1 LAg-Avidity EIA (LAg) and the Bio-Rad avidity incidence (BRAI) assays with a mean duration of recent infection (MDRI) of 130 and 240 days for subtype B infections, respectively. Little is known about how these assays perform with recombinant HIV-1 strains. We evaluated the concordance of these assays in a population infected mainly with HIV-1 CRF06_cpx. MATERIAL/METHODS: Remnant serum samples (n = 288) collected from confirmed, newly-diagnosed HIV-positive persons from Estonia in 2013 were tested. Demographic and clinical data were extracted from clinical databases. LAg was performed according to the manufacturer’s protocol and BRAI testing was done using a validated protocol. Samples with LAg-pending or BRAI-invalid results were reclassified as recent if they were from persons with viral loads <1000 copies/mL or were reclassified as long-term if presenting with AIDS. RESULTS: In total 325 new HIV infections were diagnosed in 2013 in Estonia. Of those 276 persons were tested with both LAg and BRAI. Using assay results only, the recency rate was 44% and 70% by LAg and BRAI, respectively. The majority of samples (92%) recent by LAg were recent by BRAI. Similarly, 89% of samples long-term by BRAI were long-term by LAg. After clinical information was included in the analysis, the recency rate was 44% and 62% for LAg and BRAI, respectively. The majority of samples (86%) recent by LAg were recent by BRAI and 91% of long-term infections by BRAI were long-term by LAg. CONCLUSIONS: Comparison of LAg and BRAI results in this mostly CRF06_cpx-infected population showed good concordance for incidence classification. Our finding of a higher recency rate with BRAI in this population is likely related to the longer MDRI for this assay

Discovery of survival factor for primitive chronic myeloid leukemia cells using induced pluripotent stem cells.

A definitive cure for chronic myeloid leukemia (CML) requires identifying novel therapeutic targets to eradicate leukemia stem cells (LSCs). However, the rarity of LSCs within the primitive hematopoietic cell compartment remains a major limiting factor for their study in humans. Here we show that primitive hematopoietic cells with typical LSC features, including adhesion defect, increased long-term survival and proliferation, and innate resistance to tyrosine kinase inhibitor (TKI) imatinib, can be generated de novo from reprogrammed primary CML cells. Using CML iPSC-derived primitive leukemia cells, we discovered olfactomedin 4 (OLFM4) as a novel factor that contributes to survival and growth of somatic lin(-)CD34(+) cells from bone marrow of patients with CML in chronic phase, but not primitive hematopoietic cells from normal bone marrow. Overall, this study shows the feasibility and advantages of using reprogramming technology to develop strategies for targeting primitive leukemia cells

Improved model of the triple system V746 Cassiopeiae that has a bipolar magnetic field associated with the tertiary

V746 Cas is known to be a triple system composed of a close binary with an alternatively reported period of either 25d:4 or 27d:8 and a distant third component in a 170 yr (62 000 d) orbit. The object was also reported to exhibit multiperiodic light variations with periods from 0d: 83 to 2d: 50, on the basis of which it was classified as a slowly pulsating B star. Interest in further investigation of this system was raised by the recent detection of a variable magnetic field. Analysing spectra from four instruments, earlier published radial velocities, and several sets of photometric observations, we arrived at the following conclusions: (1) The optical spectrum is dominated by the lines of the B-type primary (Teff 1 16 500(100)K), contributing 70% of the light in the optical region, and a slightly cooler B tertiary (Teff 3 13 620(150)K). The lines of the low-mass secondary are below our detection threshold; we estimate that it could be a normal A or F star. (2) We resolved the ambiguity in the value of the inner binary period and arrived at a linear ephemeris of Tsuper: conj: = HJD 2 443 838:78(81) + 25d:41569(42) × E. (3) The intensity of the magnetic field undergoes a sinusoidal variation in phase with one of the known photometric periods, namely 2d:503867(19), which we identify with the rotational period of the tertiary. (4) The second dominant photometric 1d: 0649524(40) period is tentatively identified with the rotational period of the broad-lined B-type primary, but this interpretation is much less certain and needs further verification. (5) If our interpretation of photometric periods is confirmed, the classification of the object as a slowly pulsating B star should be revised. (6) Applying an N-body model to different types of available observational data, we can constrain the orbital inclination of the inner orbit to 60° &lt; i1 &lt; 85° even in the absence of binary eclipses, and we estimate the probable properties of the triple system and its components.250015 GA15-02112S Univerzita Karlova v Praze: GA17-00871SAcknowledgements. We profited from the use of 13 echelle spectra from the Bernard Lyot telescope, made publicly available via the Polar Base web service and Geneva 7-C photometry made available via HELAS service, to which we were kindly directed by C. Aerts. P. Mathias kindly provided us with old archival DAT tapes with the original Aurelie spectra of ten B stars and some advice about their content and structure. The spectra were reconstructed from the tapes with the help of R. Vesely. H. Bozic, K. Hon^ková, and D. Vršnjak kindly obtained some of the calibrated UBV observations of V746 Cas and its comparison stars for us. We acknowledge the use of the public versions of programs FOTEL and KOREL, written by P. Hadrava and PHOEBE 1.0 written by A. Prša. The research of P.H., M.B., P.M., and J.N. was supported by the grant P209/10/0715 of the Czech Science Foundation. J.N. and P.H. were also supported by the grants GA15-02112S of the Czech Science Foundation and No. 250015 of the Grant Agency of the Charles University in Prague. Research of D.K. was supported by a grant GA17-00871S of the Czech Science Foundation. Our thanks are due to M. Wolf, who obtained one Ond^ejov spectrum used here and who provided a few useful comments to this paper. A persistent but constructive criticism by an anonymous referee helped us to re-think the whole study, present our arguments and analyses more clearly and convincingly, and to improve the layout of the text and figures as well. The use of the NASA/ADS bibliographical service and SIMBAD electronic database are gratefully acknowledged. -