Power supply Patent

Power supply with automatic power factor conversion syste

T cell-specific suppressor factor(s) with regulatory influence on interleukin 2 production and function

In this study we report that alloantigen-activated spleen cells produce both amplifying and suppressive factors under the same conditions. Both types of soluble mediators--as detected in different assay systems-- were present in the supernatants of in vivo sensitized and in vitro restimulated spleen cell populations and were separable by gel filtration. As shown by others, the amplifying factor (IL 2) was eluted in the size range of 30,000 m.w. The suppressive factor(s) (SF) was eluted in the size range of 10,000 m.w. SF was shown to inhibit the proliferative response of T cells to alloantigen, as well as the generation of regulatory T cells and cytotoxic T cells from their precursors when added at the beginning of the in vitro culture. Furthermore, SF inhibited the release of IL 2 from producer T cells but had no detectable effect on the interaction of IL 2 with receptive T cells. In addition it was shown that SF does not affect the generation of PFC from their precursors after activation by T cell-independent antigens. The results indicate that SF selectively acts on T cells and that it is involved in the regulation of the immune response by modulating early events in T cell activation

Spherical Orbifolds for Cosmic Topology

Harmonic analysis is a tool to infer cosmic topology from the measured astrophysical cosmic microwave background CMB radiation. For overall positive curvature, Platonic spherical manifolds are candidates for this analysis. We combine the specific point symmetry of the Platonic manifolds with their deck transformations. This analysis in topology leads from manifolds to orbifolds. We discuss the deck transformations of the orbifolds and give eigenmodes for the harmonic analysis as linear combinations of Wigner polynomials on the 3-sphere. These provide new tools for detecting cosmic topology from the CMB radiation.Comment: 17 pages, 9 figures. arXiv admin note: substantial text overlap with arXiv:1011.427

A Bayesian method for pulsar template generation

Extracting Times of Arrival from pulsar radio signals depends on the knowledge of the pulsars pulse profile and how this template is generated. We examine pulsar template generation with Bayesian methods. We will contrast the classical generation mechanism of averaging intensity profiles with a new approach based on Bayesian inference. We introduce the Bayesian measurement model imposed and derive the algorithm to reconstruct a "statistical template" out of noisy data. The properties of these "statistical templates" are analysed with simulated and real measurement data from PSR B1133+16. We explain how to put this new form of template to use in analysing secondary parameters of interest and give various examples: We implement a nonlinear filter for determining ToAs of pulsars. Applying this method to data from PSR J1713+0747 we derive ToAs self consistently, meaning all epochs were timed and we used the same epochs for template generation. While the average template contains fluctuations and noise as unavoidable artifacts, we find that the "statistical template" derived by Bayesian inference quantifies fluctuations and remaining uncertainty. This is why the algorithm suggested turns out to reconstruct templates of statistical significance from ten to fifty single pulses. A moving data window of fifty pulses, taking out one single pulse at the beginning and adding one at the end of the window unravels the characteristics of the methods to be compared. It shows that the change induced in the classical reconstruction is dominated by random fluctuations for the average template, while statistically significant changes drive the dynamics of the proposed method's reconstruction. The analysis of phase shifts with simulated data reveals that the proposed nonlinear algorithm is able to reconstruct correct phase information along with an acceptable estimation of the remaining uncertainty.Comment: 21 pages, 16 figures, submitted to MNRA

DNA nano-mechanics: how proteins deform the double helix

It is a standard exercise in mechanical engineering to infer the external forces and torques on a body from its static shape and known elastic properties. Here we apply this kind of analysis to distorted double-helical DNA in complexes with proteins. We extract the local mean forces and torques acting on each base-pair of bound DNA from high-resolution complex structures. Our method relies on known elastic potentials and a careful choice of coordinates of the well-established rigid base-pair model of DNA. The results are robust with respect to parameter and conformation uncertainty. They reveal the complex nano-mechanical patterns of interaction between proteins and DNA. Being non-trivially and non-locally related to observed DNA conformations, base-pair forces and torques provide a new view on DNA-protein binding that complements structural analysis.Comment: accepted for publication in JCP; some minor changes in response to review 18 pages, 5 figure + supplement: 4 pages, 3 figure

Overlapping Unit Cells in 3d Quasicrystal Structure

A 3-dimensional quasiperiodic lattice, with overlapping unit cells and periodic in one direction, is constructed using grid and projection methods pioneered by de Bruijn. Each unit cell consists of 26 points, of which 22 are the vertices of a convex polytope P, and 4 are interior points also shared with other neighboring unit cells. Using Kronecker's theorem the frequencies of all possible types of overlapping are found.Comment: LaTeX2e, 11 pages, 5 figures (8 eps files), uses iopart.class. Final versio

Tunneling out of a time-dependent well

Solutions to explicit time-dependent problems in quantum mechanics are rare. In fact, all known solutions are coupled to specific properties of the Hamiltonian and may be divided into two categories: One class consists of time-dependent Hamiltonians which are not higher than quadratic in the position operator, like i.e the driven harmonic oscillator with time-dependent frequency. The second class is related to the existence of additional invariants in the Hamiltonian, which can be used to map the solution of the time-dependent problem to that of a related time-independent one. In this article we discuss and develop analytic methods for solving time-dependent tunneling problems, which cannot be addressed by using quadratic Hamiltonians. Specifically, we give an analytic solution to the problem of tunneling from an attractive time-dependent potential which is embedded in a long-range repulsive potential. Recent progress in atomic physics makes it possible to observe experimentally time-dependent phenomena and record the probability distribution over a long range of time. Of special interest is the observation of macroscopical quantum-tunneling phenomena in Bose-Einstein condensates with time-dependent trapping potentials. We apply our model to such a case in the last section.Comment: 11 pages, 3 figure

The double torus as a 2D cosmos: groups, geometry and closed geodesics

The double torus provides a relativistic model for a closed 2D cosmos with topology of genus 2 and constant negative curvature. Its unfolding into an octagon extends to an octagonal tessellation of its universal covering, the hyperbolic space H^2. The tessellation is analysed with tools from hyperbolic crystallography. Actions on H^2 of groups/subgroups are identified for SU(1, 1), for a hyperbolic Coxeter group acting also on SU(1, 1), and for the homotopy group \Phi_2 whose extension is normal in the Coxeter group. Closed geodesics arise from links on H^2 between octagon centres. The direction and length of the shortest closed geodesics is computed.Comment: Latex, 27 pages, 5 figures (late submission to arxiv.org