98 research outputs found
Nanotomie van huid en mucosa van pemfiguspatiënten
Pemphigus is an auto-immune blistering skin and/or mucosal disease caused by antibodies against proteins of desmosomes. Desmosomes are cell-cell adhesion structures that interconnect intermediate filament networks of neighboring cells. The transmembrane desmosomal proteins that are the targets of pemphigus autoantibodies, desmoglein 1 (Dsg1) and desmoglein 3 (Dsg3), are specific for the stratified epithelia of the skin and mucosal membranes and are not present in the simple epithelia. Therefore, loss of cell-cell adhesion (acantholysis) induced by pemphigus autoantibodies and clinically presented as blistering occurs only in these tissues. Two main forms of pemphigus are known: pemphigus vulgaris (PV) and pemphigus foliaceus (PF) with a different clinical picture and a different autoantibody profile. How pemphigus autoantibodies induce loss of cell-cell adhesion is our main question. Large scale electron microscopy ("nanotomy") was applied to study pemphigus patients skin and mucosa. This non-biased technique allows easy exploration of large tissue areas which is not possible by conventional EM. We examined both skin and mucosa of PF and PV patients, focusing on ultrastructural details: localization of blister, presence of half desmosomes and localization of keratin filament network in the cells surrounding the blister and desmosomes and intercellular space in nonlesional layers. In spontaneous lesional PF patient skin no desmosomes were present round the blister, while in Nikolsky positive PF patient skin half desmosomes were observed round the blister. In all lesional pemphigus samples and to a lesser extend in non-lesional samples newly described structures named interdigitations composed out of two neighboring cell membranes were present. These structures were abundant in lesional pemphigus skin, which provides a clue to blister pathogenesis.Open source electron-microscopic maps of pemphigus tissue are freely accessible at www.nanotomy.org
Fast Photon Detection for Particle Identification with COMPASS RICH-1
Particle identification at high rates is an important challenge for many
current and future high-energy physics experiments. The upgrade of the COMPASS
RICH-1 detector requires a new technique for Cherenkov photon detection at
count rates of several per channel in the central detector region, and a
read-out system allowing for trigger rates of up to 100 kHz. To cope with these
requirements, the photon detectors in the central region have been replaced
with the detection system described in this paper. In the peripheral regions,
the existing multi-wire proportional chambers with CsI photocathode are now
read out via a new system employing APV pre-amplifiers and flash ADC chips. The
new detection system consists of multi-anode photomultiplier tubes (MAPMT) and
fast read-out electronics based on the MAD4 discriminator and the F1-TDC chip.
The RICH-1 is in operation in its upgraded version for the 2006 CERN SPS run.
We present the photon detection design, constructive aspects and the first
Cherenkov light in the detector.Comment: Proceedings of the Imaging 2006 conference, Stockholm, Sweden, 27-30
June 2006, 5 pages, 6 figures, to appear in NIM A; corrected typo in caption
of Fig.
Fast photon detection for the COMPASS RICH detector
The COMPASS experiment at the SPS accelerator at CERN uses a large scale Ring
Imaging CHerenkov detector (RICH) to identify pions, kaons and protons in a
wide momentum range. For the data taking in 2006, the COMPASS RICH has been
upgraded in the central photon detection area (25% of the surface) with a new
technology to detect Cherenkov photons at very high count rates of several 10^6
per second and channel and a new dead-time free read-out system, which allows
trigger rates up to 100 kHz. The Cherenkov photons are detected by an array of
576 visible and ultra-violet sensitive multi-anode photomultipliers with 16
channels each. The upgraded detector showed an excellent performance during the
2006 data taking.Comment: Proceeding of the IPRD06 conference (Siena, Okt. 06
The Fast Read-out System for the MAPMTs of COMPASS RICH-1
A fast readout system for the upgrade of the COMPASS RICH detector has been
developed and successfully used for data taking in 2006 and 2007. The new
readout system for the multi-anode PMTs in the central part of the photon
detector of the RICH is based on the high-sensitivity MAD4
preamplifier-discriminator and the dead-time free F1-TDC chip characterized by
high-resolution. The readout electronics has been designed taking into account
the high photon flux in the central part of the detector and the requirement to
run at high trigger rates of up to 100 kHz with negligible dead-time. The
system is designed as a very compact setup and is mounted directly behind the
multi-anode photomultipliers. The data are digitized on the frontend boards and
transferred via optical links to the readout system. The read-out electronics
system is described in detail together with its measured performances.Comment: Proceeding of RICH2007 Conference, Trieste, Oct. 2007. v2: minor
change
FORMAÇÃO HUMANA, VISÃO DE MUNDO, DIÁLOGO E EDUCAÇÃO: A ATUALIDADE DE PAULO FREIRE E MARTIN BUBER
Measurement of the Proton Spin Structure Function g1p with a Pure Hydrogen Target
A measurement of the proton spin structure function g1p(x,Q^2) in
deep-inelastic scattering is presented. The data were taken with the 27.6 GeV
longitudinally polarised positron beam at HERA incident on a longitudinally
polarised pure hydrogen gas target internal to the storage ring. The kinematic
range is 0.021<x<0.85 and 0.8 GeV^2<Q^2<20 GeV^2. The integral
Int_{0.021}^{0.85} g1p(x)dx evaluated at Q0^2 of 2.5 GeV^2 is
0.122+/-0.003(stat.)+/-0.010(syst.).Comment: 7 pages, 3 figures, 1 table, RevTeX late
Observation of a Coherence Length Effect in Exclusive Rho^0 Electroproduction
Exclusive incoherent electroproduction of the rho^0(770) meson from 1H, 2H,
3He, and 14N targets has been studied by the HERMES experiment at squared
four-momentum transfer Q**2>0.4 GeV**2 and positron energy loss nu from 9 to 20
GeV. The ratio of the 14N to 1H cross sections per nucleon, known as the
nuclear transparency, was found to decrease with increasing coherence length of
quark-antiquark fluctuations of the virtual photon. The data provide clear
evidence of the interaction of the quark- antiquark fluctuations with the
nuclear medium.Comment: RevTeX, 5 pages, 3 figure
Determination of the Deep Inelastic Contribution to the Generalised Gerasimov-Drell-Hearn Integral for the Proton and Neutron
The virtual photon absorption cross section differences [sigma_1/2-sigma_3/2]
for the proton and neutron have been determined from measurements of polarised
cross section asymmetries in deep inelastic scattering of 27.5 GeV
longitudinally polarised positrons from polarised 1H and 3He internal gas
targets. The data were collected in the region above the nucleon resonances in
the kinematic range nu < 23.5 GeV and 0.8 GeV**2 < Q**2 < 12 GeV**2. For the
proton the contribution to the generalised Gerasimov-Drell-Hearn integral was
found to be substantial and must be included for an accurate determination of
the full integral. Furthermore the data are consistent with a QCD
next-to-leading order fit based on previous deep inelastic scattering data.
Therefore higher twist effects do not appear significant.Comment: 6 pages, 3 figures, 1 table, revte
The Deuteron Spin-dependent Structure Function g1d and its First Moment
We present a measurement of the deuteron spin-dependent structure function
g1d based on the data collected by the COMPASS experiment at CERN during the
years 2002-2004. The data provide an accurate evaluation for Gamma_1^d, the
first moment of g1d(x), and for the matrix element of the singlet axial
current, a0. The results of QCD fits in the next to leading order (NLO) on all
g1 deep inelastic scattering data are also presented. They provide two
solutions with the gluon spin distribution function Delta G positive or
negative, which describe the data equally well. In both cases, at Q^2 = 3
(GeV/c)^2 the first moment of Delta G is found to be of the order of 0.2 - 0.3
in absolute value.Comment: fits redone using MRST2004 instead of MRSV1998 for G(x), correlation
matrix adde
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