Rotating Boson Stars and Q-Balls

We consider axially symmetric, rotating boson stars. Their flat space limits represent spinning Q-balls. We discuss their properties and determine their domain of existence. Q-balls and boson stars are stationary solutions and exist only in a limited frequency range. The coupling to gravity gives rise to a spiral-like frequency dependence of the boson stars. We address the flat space limit and the limit of strong gravitational coupling. For comparison we also determine the properties of spherically symmetric Q-balls and boson stars.Comment: 22 pages, 18 figure

Rotating Boson Stars and Q-Balls II: Negative Parity and Ergoregions

We construct axially symmetric, rotating boson stars with positive and negative parity. Their flat space limits represent spinning Q-balls. $Q$-balls and boson stars exist only in a limited frequency range. The coupling to gravity gives rise to a spiral-like frequency dependence of the mass and charge of boson stars. We analyze the properties of these solutions. In particular, we discuss the presence of ergoregions in boson stars, and determine their domains of existence.Comment: 20 pages, 17 figure

Heatwave-associated Vibrio infections in Germany, 2018 and 2019

Background: Vibrio spp. are aquatic bacteria that prefer warm seawater with moderate salinity. In humans, they can cause gastroenteritis, wound infections, and ear infections. During the summers of 2018 and 2019, unprecedented high sea surface temperatures were recorded in the German Baltic Sea. Aim: We aimed to describe the clinical course and microbiological characteristics of Vibrio infections in Germany in 2018 and 2019. Methods: We performed an observational retrospective multi-centre cohort study of patients diagnosed with domestically-acquired Vibrio infections in Germany in 2018 and 2019. Demographic, clinical, and microbiological data were assessed, and isolates were subjected to whole genome sequencing and antimicrobial susceptibility testing. Results: Of the 63 patients with Vibrio infections, most contracted the virus between June and September, primarily in the Baltic Sea: 44 (70%) were male and the median age was 65 years (range: 2–93 years). Thirty-eight patients presented with wound infections, 16 with ear infections, six with gastroenteritis, two with pneumonia (after seawater aspiration) and one with primary septicaemia. The majority of infections were attributed to V. cholerae (non–O1/non-O139) (n = 30; 48%) or V. vulnificus (n = 22; 38%). Phylogenetic analyses of 12 available isolates showed clusters of three identical strains of V. vulnificus, which caused wound infections, suggesting that some clonal lines can spread across the Baltic Sea. Conclusions: During the summers of 2018 and 2019, severe heatwaves facilitated increased numbers of Vibrio infections in Germany. Since climate change is likely to favour the proliferation of these bacteria, a further increase in Vibrio-associated diseases is expected.Peer Reviewe

Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor

Retinitis pigmentosa results in blindness due to degeneration of photoreceptors, but spares other retinal cells, leading to the hope that expression of light-activated signaling proteins in the surviving cells could restore vision. We used a retinal G protein-coupled receptor, mGluR2, which we chemically engineered to respond to light. In retinal ganglion cells (RGCs) of blind rd1 mice, photoswitch-charged mGluR2 ("SNAG-mGluR2") evoked robust OFF responses to light, but not in wild-type retinas, revealing selectivity for RGCs that have lost photoreceptor input. SNAG-mGluR2 enabled animals to discriminate parallel from perpendicular lines and parallel lines at varying spacing. Simultaneous viral delivery of the inhibitory SNAG-mGluR2 and excitatory light-activated ionotropic glutamate receptor LiGluR yielded a distribution of expression ratios, restoration of ON, OFF and ON-OFF light responses and improved visual acuity. Thus, SNAG-mGluR2 restores patterned vision and combinatorial light response diversity provides a new logic for enhanced-acuity retinal prosthetics

Plasma lipid profiles discriminate bacterial from viral infection in febrile children

Fever is the most common reason that children present to Emergency Departments. Clinical signs and symptoms suggestive of bacterial infection are often non-specific, and there is no definitive test for the accurate diagnosis of infection. The 'omics' approaches to identifying biomarkers from the host-response to bacterial infection are promising. In this study, lipidomic analysis was carried out with plasma samples obtained from febrile children with confirmed bacterial infection (n = 20) and confirmed viral infection (n = 20). We show for the first time that bacterial and viral infection produces distinct profile in the host lipidome. Some species of glycerophosphoinositol, sphingomyelin, lysophosphatidylcholine and cholesterol sulfate were higher in the confirmed virus infected group, while some species of fatty acids, glycerophosphocholine, glycerophosphoserine, lactosylceramide and bilirubin were lower in the confirmed virus infected group when compared with confirmed bacterial infected group. A combination of three lipids achieved an area under the receiver operating characteristic (ROC) curve of 0.911 (95% CI 0.81 to 0.98). This pilot study demonstrates the potential of metabolic biomarkers to assist clinicians in distinguishing bacterial from viral infection in febrile children, to facilitate effective clinical management and to the limit inappropriate use of antibiotics

Time analysis of stacker cranes – comparing theory with reality

Spielzeiten von RBGs sind in der heutigen Zeit ein entscheidendes, markendifferenzierendes Kriterium bei der Abnahme von Lagerdurchsätzen. In diesem Beitrag werden die aktuellen Forschungsergebnisse zur Spielzeitanalyse an RBGs vorgestellt sowie Begründungen und Antworten auf die Leitfragen gegeben: Wie groß ist der Unterschied der mittleren Spielzeiten beim Einzelspiel zwischen Realität und Theorie?Timing constraints are major competitive parameters for the differentiation of stacker cranes in throughput. For that reason we will present in this paper our actual research results of timing analysis of stacker cranes and give answers to the research question: How big is the difference in mean single command cycle time between reality and theory

Validation of intralogistic system models by means of measured system key performance indicators

Die konsequente Anwendung von einer Validie-rungsmethoden ist eine wichtige Grundlage zur Angabe der Genauigkeit von Simulationsmodellen. Im nachfolgenden Beitrag wird eine Vorgehensweise zur Validierung von Simulationsmodellen vorgestellt und auf ein am Institut für Fördertechnik und Logistiksysteme (IFL) entwickeltes Modell zur Quantifizierung des Energiebedarfs und der Spielzeit von Regalbediengeräten angewandt und analysiert.The consistent application of validation methods is necessary for the evaluation of the accuracy of sim-ulation models. In this article a method of validation will be applied to the simulation model for quantification of energy demand of AS/RS which are developed at Institut für Fördertechnik und Logistiksysteme (IFL). Afterwards the results will be analyzed and evaluated

Repeatability of empirical surveys of measured data using statistical implications

Die Wahrung der Reproduzierbarkeit empirisch erhobener Messdaten fordert eine konsequente Anwendung einer einheitlichen und standardisierten Methode. Am IFL des KIT wurde deshalb eine Prozessbeschreibung entworfen, die speziell für die Messung von Fördermitteln der Intralogistik angewandt werden kann. Neben der Vorbereitung und Durchführung der Messungen müssen die erhobenen Daten anschließend statistisch ausgewertet und interpretiert werden. Die Methode wird in diesem Beitrag vorgestellt und am Beispiel von Leistungs- und Energiemessungen angewandt.Ensuring reproducibility of empirical measurement data needs a consequent utilization of homogeneous and standardized methods. For that an integrative process description was formulated by IFL at KIT which is specially designed for measurements of material handling equipment in intralogistics systems. Beside preparation and performing of the measurements the resulting data have to be statistically analyzed and interpreted. The mentioned method is in the focus of this paper and will be shown on an example of power and energy measurements