Escape Routes in Road and Railway Tunnels Using TBM technology vs. NATM

Import 02/11/2016Import 20/01/2016Import 11/02/2016Moje diplomová práce se zabývá problematikou technologie TBM a NRTM – únikové cesty v silničních a železničních tunelech. V úvodu je popsána technologie plnoprofilového razícího stroje (TBM – Tunnel Boring Machines) a nové rakouské tunelovací metodě (NRTM), jejich pozitiva a negativa. Následně je řešen projekt tunelu Ejpovice a metody konstrukčních řešení napojení tunelové propojky na traťový tunel. Dále je řešen matematický model na tunelu v Ejpovicích v softwaru Midas.My master thesis deals with escape routes in road and railway tunnels using TBM technology vs. NATM. In the introduction describes the technology Tunnel Boring Machines (TBM) and New Austrian tunnelling method (NATM), they advantages and disadvantages. Subsequently, the project focused on the tunnel Ejpovice methods and design solutions connecting cross passage on track tunnel. Also describe mathematical model on the tunnel in Ejpovice in software Midas.224 - Katedra geotechniky a podzemního stavitelstvívelmi dobř

Slope Stability to Secure Road Construction

Import 05/08/2014Moje bakalářská práce se zabývá problematikou stability svahu. V úvodu jsou základní poznatky, jako jsou obecné charakteristiky svahů a svahových pohybů, zahrnující příčiny, typy, klasifikaci a faktory ovlivňující stabilitu svahu. Následně jsou popsány možnosti technického řešení stability svahů. Dále popisuji systém kontrolního monitoringu, jak na povrchu tak uvnitř svahu. V neposlední řadě uvádím metody výpočtu stability svahu. Jako poslední bod uvádím kontrolní posouzení stability obecného svahu v softwaru GEO5.My bachelor thesis deals with the stability of the slope. In the introduction to the basic knowledge, such as general characteristics of slopes and landslides, including causes, types, classification and factors affecting slope stability. Subsequently, the possibilities of technical slope stability analysis. Also describe the control system of monitoring, both on the surface and inside the slope. Finally, I present methods of calculating slope stability. As a final point I mention checking the stability of the slope in software GEO5.Prezenční224 - Katedra geotechniky a podzemního stavitelstvívýborn

Pupils’ preconceptions about heat, temperature and energy

This article is focused on finding out pupils’ preconceptions about heat, temperature and energy. As a research tool we used a didactic test with individual types of tasks about the concepts. A total of 122 respondents aged 12 to 14 participated in the research. The research sample consisted of two groups of pupils. One group consisted of pupils attending a school assigned for talented pupils, for simplicity they are referred as talented pupils. The second group consisted of pupils who do not attend this type of school, we marked them as “general population”. The number of respondents in the sample of talented pupils was 54. The number of respondents in the sample “general population” was 68 pupils. In the research we compared ideas about concepts heat, temperature and energy of talented pupils and pupils of the “general population”. We also compared talented pupils and pupils of the “general population” in solving of conceptual and algorithmic tasks in didactic test. We found out pupils of the age from 12 to 14 have misconceptions about the concepts. We also identified the misconceptions and the most common are also mentioned in this article

Severe child form of primary hyperoxaluria type 2 - a case report revealing consequence of GRHPR deficiency on metabolism

Abstract Background Primary hyperoxaluria type 2 is a rare monogenic disorder inherited in an autosomal recessive pattern. It results from the absence of the enzyme glyoxylate reductase/hydroxypyruvate reductase (GRHPR). As a consequence of deficient enzyme activity, excessive amounts of oxalate and L-glycerate are excreted in the urine, and are a source for the formation of calcium oxalate stones that result in recurrent nephrolithiasis and less frequently nephrocalcinosis. Case presentation We report a case of a 10-month-old patient diagnosed with urolithiasis. Screening of inborn errors of metabolism, including the performance of GC/MS urine organic acid profiling and HPLC amino acid profiling, showed abnormalities, which suggested deficiency of GRHPR enzyme. Additional metabolic disturbances observed in the patient led us to seek other genetic determinants and the elucidation of these findings. Besides the elevated excretion of 3-OH-butyrate, adipic acid, which are typical marks of ketosis, other metabolites such as 3-aminoisobutyric acid, 3-hydroxyisobutyric acid, 3-hydroxypropionic acid and 2-ethyl-3-hydroxypropionic acids were observed in increased amounts in the urine. Direct sequencing of the GRHPR gene revealed novel mutation, described for the first time in this article c.454dup (p.Thr152Asnfs*39) in homozygous form. The frequent nucleotide variants were found in AGXT2 gene. Conclusions The study presents metabolomic and molecular-genetic findings in a patient with PH2. Mutation analysis broadens the allelic spectrum of the GRHPR gene to include a novel c.454dup mutation that causes the truncation of the GRHPR protein and loss of its two functional domains. We also evaluated whether nucleotide variants in the AGXT2 gene could influence the biochemical profile in PH2 and the overproduction of metabolites, especially in ketosis. We suppose that some metabolomic changes might be explained by the inhibition of the MMSADH enzyme by metabolites that increase as a consequence of GRHPR and AGXT2 enzyme deficiency. Several facts support an assumption that catabolic conditions in our patient could worsen the degree of hyperoxaluria and glyceric aciduria as a consequence of the elevated production of free amino acids and their intermediary products