Neutron Scattering Study of Crystal Field Energy Levels and Field Dependence of the Magnetic Order in Superconducting HoNi2B2C

Elastic and inelastic neutron scattering measurements have been carried out to investigate the magnetic properties of superconducting (Tc~8K) HoNi2B2C. The inelastic measurements reveal that the lowest two crystal field transitions out of the ground state occurat 11.28(3) and 16.00(2) meV, while the transition of 4.70(9) meV between these two levels is observed at elevated temperatures. The temperature dependence of the intensities of these transitions is consistent with both the ground state and these higher levels being magnetic doublets. The system becomes magnetically long range ordered below 8K, and since this ordering energy kTN ~ 0.69meV << 11.28meV the magnetic properties in the ordered phase are dominated by the ground-state spin dynamics only. The low temperature structure, which coexists with superconductivity, consists of ferromagnetic sheets of Ho{3+ moments in the a-b plane, with the sheets coupled antiferromagnetically along the c-axis. The magnetic state that initially forms on cooling, however, is dominated by an incommensurate spiral antiferromagnetic state along the c-axis, with wave vector qc ~0.054 A-1, in which these ferromagnetic sheets are canted from their low temperature antiparallel configuration by ~17 deg. The intensity for this spiral state reaches a maximum near the reentrant superconducting transition at ~5K; the spiral state then collapses at lower temperature in favor of the commensurate antiferromagnetic state. We have investigated the field dependence of the magnetic order at and above this reentrant superconducting transition. Initially the field rotates the powder particles to align the a-b plane along the field direction, demonstrating that the moments strongly prefer to lie within this plane due to the crystal field anisotropy. Upon subsequently increasing the field atComment: RevTex, 7 pages, 11 figures (available upon request); Physica

One Loop Renormalizability of Spontaneously Broken Gauge Theory with a Product of Gauge Groups on Noncommutative Spacetime: the U(1) x U(1) Case

A generalization of the standard electroweak model to noncommutative spacetime would involve a product gauge group which is spontaneously broken. Gauge interactions in terms of physical gauge bosons are canonical with respect to massless gauge bosons as required by the exact gauge symmetry, but not so with respect to massive ones; and furthermore they are generally asymmetric in the two sets of gauge bosons. On noncommutative spacetime this already occurs for the simplest model of U(1) x U(1). We examine whether the above feature in gauge interactions can be perturbatively maintained in this model. We show by a complete one loop analysis that all ultraviolet divergences are removable with a few renormalization constants in a way consistent with the above structure.Comment: 24 pages, figures using axodraw; version 2: a new ref item [4] added to cite efforts to all orders, typos fixed and minor rewordin

Landscape and selection of vaccine epitopes in SARS-CoV-2

Background: Early in the pandemic, we designed a SARS-CoV-2 peptide vaccine containing epitope regions optimized for concurrent B cell, CD4+ T cell, and CD8+ T cell stimulation. The rationale for this design was to drive both humoral and cellular immunity with high specificity while avoiding undesired effects such as antibody-dependent enhancement (ADE). Methods: We explored the set of computationally predicted SARS-CoV-2 HLA-I and HLA-II ligands, examining protein source, concurrent human/murine coverage, and population coverage. Beyond MHC affinity, T cell vaccine candidates were further refined by predicted immunogenicity, sequence conservation, source protein abundance, and coverage of high frequency HLA alleles. B cell epitope regions were chosen from linear epitope mapping studies of convalescent patient serum, followed by filtering for surface accessibility, sequence conservation, spatial localization near functional domains of the spike glycoprotein, and avoidance of glycosylation sites. Results: From 58 initial candidates, three B cell epitope regions were identified. From 3730 (MHC-I) and 5045 (MHC-II) candidate ligands, 292 CD8+ and 284 CD4+ T cell epitopes were identified. By combining these B cell and T cell analyses, as well as a manufacturability heuristic, we proposed a set of 22 SARS-CoV-2 vaccine peptides for use in subsequent murine studies. We curated a dataset of ~ 1000 observed T cell epitopes from convalescent COVID-19 patients across eight studies, showing 8/15 recurrent epitope regions to overlap with at least one of our candidate peptides. Of the 22 candidate vaccine peptides, 16 (n = 10 T cell epitope optimized; n = 6 B cell epitope optimized) were manually selected to decrease their degree of sequence overlap and then synthesized. The immunogenicity of the synthesized vaccine peptides was validated using ELISpot and ELISA following murine vaccination. Strong T cell responses were observed in 7/10 T cell epitope optimized peptides following vaccination. Humoral responses were deficient, likely due to the unrestricted conformational space inhabited by linear vaccine peptides. Conclusions: Overall, we find our selection process and vaccine formulation to be appropriate for identifying T cell epitopes and eliciting T cell responses against those epitopes. Further studies are needed to optimize prediction and induction of B cell responses, as well as study the protective capacity of predicted T and B cell epitopes

Synthesis and characterization of Ba3(Pb1-xBix)2O7

The synthesis and initial characterization of a layered perovskite-based lead-bismuth oxide are reported. The phase, Ba3(Pb1-xBix)2O7, for 0≤x≤0.5, is the n=2 member of the Ruddlesden-Popper series An+1BnO3n+1. It can be synthesized only under very narrowly defined conditions. Despite the analogy to the well-known three-dimensional perovskite superconductor BaPb0.75Bi0.25O3, layered Ba3Pb2O7 does not become superconducting (down to 1.8 K) on doping with Bi.

Cs8.5W15O48 and CsW2O6: Members of a New Homologous Series of Cesium Tungsten Oxides

The crystal structures of two new reduced cesium tungsten oxides are reported. Along with the previously reported compound Cs6W11O36, they represent several members of a homologous series of layer compounds between the hexagonal tungsten bronze and pyrochlore structure types. The series formula is [A] Cs2nW4n–1O12n, where n – 1 is the number of pyrochlore layers.