The Delphi Method for Graduate Research

Introduction It continues to be an exciting time to be a researcher in the information systems discipline; there seems to be a plethora of interesting and pressing research topics suitable for research at the masters or PhD level. Researchers may want to look forward to see what will be the key information systems issues in a wireless world, the ethical dilemmas in social network analysis, and the lessons early adopters learn. Practitioners may be interested in what others think about the strengths and weaknesses of an existing information system, or the effectiveness of a newly implemented information system. The Delphi method can help to uncover data in these research directions. The Delphi method is an iterative process used to collect and distill the judgments of experts using a series of questionnaires interspersed with feedback. The questionnaires are designed to focus on problems, opportunities, solutions, or forecasts. Each subsequent questionnaire is developed based on the results of the previous questionnaire. The process stops when the research question is answered: for example, when consensus is reached, theoretical saturation is achieved, or when sufficient information has been exchanged. The Delphi method has its origins in the American business community, and has since been widely accepted throughout the world in many industry sectors including health care, defense, business, education, information technology, transportation and engineering. The Delphi method\u27s flexibility is evident in how it has been used. It is a method for structuring a group communication process to facilitate group problem solving and to structure models (Linstone & Turloff, 1975). The method can also be used as a judgment, decision-aiding or forecasting tool (Rowe & Wright, 1999), and can be applied to program planning and administration (Delbeq, Van de Ven, & Gustafson, 1975). The Delphi method can be used when there is incomplete knowledge about a problem or phenomena (Adler & Ziglio, 1996; Delbeq et al., 1975). The method can be applied to problems that do not lend themselves to precise analytical techniques but rather could benefit from the subjective judgments of individuals on a collective basis (Adler & Ziglio, 1996) and to focus their collective human intelligence on the problem at hand (Linstone & Turloff, 1975). Also, the Delphi is used to investigate what does not yet exist (Czinkota & Ronkainen, 1997; Halal, Kull, & Leffmann, 1997; Skulmoski & Hartman 2002). The Delphi method is a mature and a very adaptable research method used in many research arenas by researchers across the globe. To better understand its diversity in application, one needs to consider the origins of the Delphi method. The Classical Delphi The original Delphi method was developed by Norman Dalkey of the RAND Corporation in the 1950\u27s for a U.S. sponsored military project. Dalkey states that the goal of the project was to solicit expert opinion to the selection, from the point of view of a Soviet strategic planner, of an optimal U.S. industrial target system and to the estimation of the number of A-bombs required to reduce the munitions output by a prescribed amount, (Dalkey & Helmer, 1963, p. 458). Rowe and Wright (1999) characterize the classical Delphi method by four key features: 1. Anonymity of Delphi participants: allows the participants to freely express their opinions without undue social pressures to conform from others in the group. Decisions are evaluated on their merit, rather than who has proposed the idea. 2. Iteration: allows the participants to refine their views in light of the progress of the group\u27s work from round to round. 3. Controlled feedback: informs the participants of the other participant\u27s perspectives, and provides the opportunity for Delphi participants to clarify or change their views. 4. Statistical aggregation of group response: allows for a quantitative analysis and interpretation of data.

Circulating endothelial cells as biomarker for cardiovascular diseases.

Background: Endothelial dysfunction is involved in several cardiovascular diseases. Elevated levels of circulating endothelial cells (CECs) and low levels of endothelial progenitor cells (EPCs) have been described in different cardiovascular conditions, suggesting their potential use as diagnostic biomarkers for endothelial dysfunction. Compared to typical peripheral blood leukocyte subsets, CECs and EPCs occur at very low frequency. The reliable identification and characterization of CECs and EPCs is a prerequisite for their clinical use, however, a validated method to this purpose is still missing but a key for rare cell events. Objectives: To establish a validated flow cytometric procedure in order to quantify CECs and EPCs in human whole blood. Methods: In the establishment phase, the assay sensitivity, robustness, and the sample storage conditions were optimized as prerequisite for clinical use. In a second phase, CECs and EPCs were analyzed in heart failure with preserved (HFpEF) and reduced (HFrEF) ejection fraction, in arterial hypertension (aHT), and in diabetic nephropathy (DN) in comparison to age-matched healthy controls. Results: The quantification procedure for CECs and EPCs showed high sensitivity and reproducibility. CEC values resulted significantly increased in patients with DN and HFpEF in comparison to healthy controls. CEC quantification showed a diagnostic sensitivity of 90% and a sensitivity of 68.0%, 70.4%, and 66.7% for DN, HFpEF, and aHT, respectively. Conclusion: A robust and precise assay to quantify CECs and EPCs in pre-clinical and clinical studies has been established. CEC counts resulted to be a good diagnostic biomarker for DN and HFpEF

PIN1 TREATMENT OF HEPATITIS C INFECTION FOR CURRENT OR FORMER SUBSTANCE ABUSERS IN A COMMUNITY SETTING

We report the use of PbS nanocrystals within a hybrid device that emits 1.2 mu m electroluminescence with an external quantum efficiency of 1.15% corresponding to an internal quantum efficiency of similar to 5%-12% thus demonstrating a viable, low-cost, highly efficient near infrared organic electroluminescent device. Direct generation of the excited state on the nanocrystal result in eliminating competing processes that have previously led to the low reported efficiencies in near-infrared light emitting devices. Furthermore, the emission wavelength can be tuned to cover a wide range of wavelengths including the 1.3-1.5 mu m region without significant change of the efficiency. (c) 2008 American Institute of Physics

Lieb-Thirring inequalities for geometrically induced bound states

We prove new inequalities of the Lieb-Thirring type on the eigenvalues of Schr\"odinger operators in wave guides with local perturbations. The estimates are optimal in the weak-coupling case. To illustrate their applications, we consider, in particular, a straight strip and a straight circular tube with either mixed boundary conditions or boundary deformations.Comment: LaTeX2e, 14 page

Health-state utilities in a prisoner population : a cross-sectional survey

Background: Health-state utilities for prisoners have not been described. Methods: We used data from a 1996 cross-sectional survey of Australian prisoners (n = 734). Respondent-level SF-36 data was transformed into utility scores by both the SF-6D and Nichol's method. Socio-demographic and clinical predictors of SF-6D utility were assessed in univariate analyses and a multivariate general linear model. Results: The overall mean SF-6D utility was 0.725 (SD 0.119). When subdivided by various medical conditions, prisoner SF-6D utilities ranged from 0.620 for angina to 0.764 for those with none/mild depressive symptoms. Utilities derived by the Nichol's method were higher than SF-6D scores, often by more than 0.1. In multivariate analysis, significant independent predictors of worse utility included female gender, increasing age, increasing number of comorbidities and more severe depressive symptoms. Conclusion: The utilities presented may prove useful for future economic and decision models evaluating prison-based health programs