Nível de energia metabolizável aparente sobre o desempenho zootécnico de frangos de corte.

O milho é o principal ingrediente energético utilizado nas rações brasileiras para frango de corte. O frango de corte macho de desempenho superior necessita segundo Rostagno (1) cerca de 3.150 e 3.200 kcal/kg no período de 22 à 33 e 34 à 42 dias de idade, respectivamente. Para atender essa demanda energética óleos e gordura são incluídos nas formulações. O objetivo do trabalho foi avaliar o requerimento energia metabolizável aparente (EMA) de frangos de corte machos consumindo dieta peletizada/triturada de 21 a 42 dias com base nas variáveis de desempenho zootécnico

Peso relativo de órgãos de frangos de corte alimentados com diferentes dietas.

No Brasil, para atender as exigências nutricionais, as dietas para monogástricos são formuladas principalmente a base de milho e farelo de soja, entretanto estas matérias-primas apresentam alto valor no mercado, com isso, tem-se buscado alternativas para substitui-las nas dietas. Por outro lado, alimentos alternativos podem conter fatores antinutricionais, como por exemplo os fitatos que podem formar complexos insolúveis com proteínas e minerais ? reduzindo a disponibilidade destes nutrientes. O uso de enzimas exógenas nas dietas de frangos pode trazer alguns benefícios, tais como: redução na viscosidade da digesta, melhora da digestão e absorção de nutrientes, aumento no consumo alimentar, melhora ganho de peso e na conversão alimentar, diminuição do tamanho do trato gastrointestinal, alteração na população de microrganismos do trato gastrointestinal, redução do consumo de água e do conteúdo de água nas excretas e reduz a excreção de nutrientes (2). Objetivou-se com este trabalho avaliar o efeito das dietas experimentais sobre o peso relativo da moela, fígado e ceco de frangos de corte, quando alimentados com com dietas contendo diferentes matérias primas na presença e ausência de fitase

Integral Field Spectroscopy of a Candidate Disk Galaxy at z~1.5 using Laser Guide Star Adaptive Optics

We present 0.1" resolution near-infrared integral field spectroscopy of Halpha in a z=1.4781 star forming galaxy, Q2343-BM133. These observations were obtained with OSIRIS (OH Suppressing Infra-Red Imaging Spectrograph) using the W.M. Keck Observatory Laser Guide Star Adaptive Optics system. Halpha emission is resolved over a 0.8" (6.8 kpc) x 0.5" (4.3 kpc) region with a 0.1" spatial resolution. We find a global flux of 4.2+/-0.6x10^{-16} ergs s^{-1} cm^{-2}, and detect a spatially resolved velocity gradient of ~134 km s^{-1} across the galaxy and a global velocity dispersion of 73+/-9 km s^{-1}. An upper limit of NII/Halpha < 0.12 is inferred, which implies that this galaxy is not dominated by an active galactic nucleus and has a metallicity at or below 1/2 solar metallicity. We derive a star formation rate (SFR) of 47+/-6 Msun yr^{-1}, and a dereddened SFR of 66+/-9 Msun yr^{-1}. Two-dimensional kinematics for Q2343-BM133 fit well with an inclined-disk model, with which we estimate an enclosed mass of 4.3x10^{9} Msun within 5.5 kpc. A possible merger scenario is also presented, and can not be fully ruled out. We derive a virial mass of 1.1x10^{10} Msun for a disk geometry, using the observed velocity dispersion. We propose that Q2343-BM133 is currently at an early stage of disk formation at a look-back time of 9.3 Gyr.Comment: 21 pages, 5 figures, ApJ accepte

Elusive Active Galactic Nuclei

A fraction of active galactic nuclei do not show the classical Seyfert-type signatures in their optical spectra, i.e. they are optically "elusive". X-ray observations are an optimal tool to identify this class of objects. We combine new Chandra observations with archival X-ray data in order to obtain a first estimate of the fraction of elusive AGN in local galaxies and to constrain their nature. Our results suggest that elusive AGN have a local density comparable to or even higher than optically classified Seyfert nuclei. Most elusive AGN are heavily absorbed in the X-rays, with gas column densities exceeding 10^24 cm^-2, suggesting that their peculiar nature is associated with obscuration. It is likely that in elusive AGN, the nuclear UV source is completely embedded and the ionizing photons cannot escape, which prevents the formation of a classical Narrow Line Region. Elusive AGN may contribute significantly to the 30 keV bump of the X-ray background.Comment: accepted for publication in MNRAS Letters, 6 pages, 3 figures, typos and references correcte

N-band Imaging of Seyfert Nuclei and the MIR-X-ray correlation

We present new mid-infrared (N-band) images of a sample of eight nearby Seyfert galaxies. In all of our targets, we detect a central unresolved source, which in some cases has been identified for the first time. In particular, we have detected the mid-infrared emission from the active nucleus of NGC 4945, which previously remained undetected at any wavelength but hard X-rays. We also detect circumnuclear extended emission in the Circinus galaxy along its major axis, and find marginal evidence for extended circumnuclear emission in NGC 3281. The high spatial resolution (1.7") of our data allows us to separate the flux of the nuclear point sources from the extended circumnuclear starburst (if present). We complement our sample with literature data for a number of non-active starburst galaxies, and relate the nuclear N-band flux to published hard (2-10 kev) X-ray fluxes. We find tight and well-separated correlations between nuclear N-band flux and X-ray flux for both Seyfert and starburst nuclei which span over 3 orders of magnitude in luminosity. We demonstrate that these correlations can be used as a powerful classification tool for galactic nuclei. For example, we find strong evidence against NGC 1808 currently harbouring an active Seyfert nucleus based on its position in the mid-infrared-X-ray diagram. On the other hand, we confirm that NGC 4945 is in fact a Seyfert 2 galaxy.Comment: 31 pages, incl. 4 figures, uses AASTex. Replaced with accepted version after minor modifications. To appear in Ap

Concomitant CIS on TURBT does not impact oncological outcomes in patients treated with neoadjuvant or induction chemotherapy followed by radical cystectomy

© Springer-Verlag GmbH Germany, part of Springer Nature 2018Background: Cisplatin-based neoadjuvant chemotherapy (NAC) for muscle invasive bladder cancer improves all-cause and cancer specific survival. We aimed to evaluate whether the detection of carcinoma in situ (CIS) at the time of initial transurethral resection of bladder tumor (TURBT) has an oncological impact on the response to NAC prior to radical cystectomy. Patients and methods: Patients were identified retrospectively from 19 centers who received at least three cycles of NAC or induction chemotherapy for cT2-T4aN0-3M0 urothelial carcinoma of the bladder followed by radical cystectomy between 2000 and 2013. The primary and secondary outcomes were pathological response and overall survival, respectively. Multivariable analysis was performed to determine the independent predictive value of CIS on these outcomes. Results: Of 1213 patients included in the analysis, 21.8% had concomitant CIS. Baseline clinical and pathologic characteristics of the ‘CIS’ versus ‘no-CIS’ groups were similar. The pathological response did not differ between the two arms when response was defined as pT0N0 (17.9% with CIS vs 21.9% without CIS; p = 0.16) which may indicate that patients with CIS may be less sensitive to NAC or ≤ pT1N0 (42.8% with CIS vs 37.8% without CIS; p = 0.15). On Cox regression model for overall survival for the cN0 cohort, the presence of CIS was not associated with survival (HR 0.86 (95% CI 0.63–1.18; p = 0.35). The presence of LVI (HR 1.41, 95% CI 1.01–1.96; p = 0.04), hydronephrosis (HR 1.63, 95% CI 1.23–2.16; p = 0.001) and use of chemotherapy other than ddMVAC (HR 0.57, 95% CI 0.34–0.94; p = 0.03) were associated with shorter overall survival. For the whole cohort, the presence of CIS was also not associated with survival (HR 1.05 (95% CI 0.82–1.35; p = 0.70). Conclusion: In this multicenter, real-world cohort, CIS status at TURBT did not affect pathologic response to neoadjuvant or induction chemotherapy. This study is limited by its retrospective nature as well as variability in chemotherapy regimens and surveillance regimens.Peer reviewedFinal Accepted Versio

Impact of cocoa flavanol intake on age-dependent vascular stiffness in healthy men: a randomized, controlled, double-masked trial

Increased vascular stiffness, endothelial dysfunction, and isolated systolic hypertension are hallmarks of vascular aging. Regular cocoa flavanol (CF) intake can improve vascular function in healthy young and elderly at-risk individuals. However, the mechanisms underlying CF bioactivity remain largely unknown. We investigated the effects of CF intake on cardiovascular function in healthy young and elderly individuals without history, signs, or symptoms of cardiovascular disease by applying particular focus on functional endpoints relevant to cardiovascular aging. In a randomized, controlled, double-masked, parallel-group dietary intervention trial, 22 young (<35yrs) and 20 elderly (50-80yrs) healthy, male non- smokers consumed either a CF-containing drink (450mg CF) or nutrient-matched, CF-free control drink bi-daily for 14 days. The primary endpoint was endothelial function as measured by flow-mediated vasodilation (FMD). Secondary endpoints included cardiac output, vascular stiffness, conductance of conduit and resistance arteries, and perfusion in the microcirculation. Following 2 weeks of CF intake, FMD improved in young (6.1±0.7% vs. 7.6±0.7%, p<0.001) and elderly (4.9±0.6% vs. 6.3±0.9%, p<0.001). Secondary outcomes demonstrated in both groups that CF intake decreased pulse wave velocity and lowered total peripheral resistance, increased arteriolar- and microvascular vasodilator capacity, red cell deformability, and diastolic blood pressure, while cardiac output remained affected. In the elderly, baseline systolic blood pressure was elevated, driven by an arterial stiffness-related augmentation. CF intake decreased aortic augmentation index (-9%), and thus systolic blood pressure (-7mmHg). (Clinicaltrials.gov:NCT01639781) CF intake reverses age-related burden of cardiovascular risk in healthy elderly, highlighting the potential of dietary flavanols to maintain cardiovascular health

How do Zimbabweans value health states?

Background Quality of life weights based on valuations of health states are often used in cost utility analysis and population health measures. This paper reports on an attempt to develop quality of life weights within the Zimbabwe context. Methods 2,384 residents in randomly selected small residential plots of land in a high-density suburb of Harare valued descriptors of 38 health states based on different combinations of the five domains of the EQ-5D (mobility, self-care, usual activities, pain or discomfort and anxiety or depression). The English version of the EQ-5D was used. The time trade-off method was used to determine the values, and 19,020 individual preferences for health states were analysed. A residual maximum likelihood linear mixed model was used to estimate a function for predicting the values of all possible combinations of levels on the five domains. The model was fit to a random subset of two-thirds of the observations, with the remaining observations reserved for analysis of predictive validity. The results were compared to a similar study undertaken in the United Kingdom. Results A credible model was developed to predict the values of states that were not valued directly. In the subset of observations reserved for validation, the mean absolute difference between predicted and observed values was 0.045. All domains of the EQ-5D were found to contribute significantly to the model, both at the moderate and severe levels. Severe pain was found to have the largest negative coefficient, followed by the inability to wash and dress oneself. Conclusion Despite a generally lower education level than their European counterparts, urban Zimbabweans appear to value health states in a consistent manner, and the determination of a global method of establishing quality of life weights may be feasible and valid. However, as the relative weightings of the different domains, although correlated, differed from the standard set of weights recommended by the EuroQol Group, the locally determined coefficients should be used within the Zimbabwean context