Peran Mediasi Pembelajaran Organisasi pada Hubungan Budaya Organisasi dan Kinerja

This study investigates the relationship between the components of organizational culture and Lecturer Performance between academics. It is hypothesized that Organizational Learning has a positive mediating role to explain the relationship between organizational culture and lecturer performance. To reveal the relationship between  the components of organizational culture  perception and  lecturer performance, a correlational research design was carried out using SMART PLS 3.2 with a total sample of 35 lecturers. Organizational Learning plays a role in mediating the relationship between Organizational Culture and Lecturer Performance. The study is limited to one private college, the sample size is not represented, so the limited results have not been able to be used as an extensive reference for private universities. Although there have been studies that discuss the relationship between organizational culture and lecturer performance, not many researchers have researched related to learning as mediation.  The results of this paper focus on various aspects of organizational learning for  the development of private universities and contribute to  the needs of human resource development

Dronedarone.

Amiodarone is the most effective antiarrhythmic drug for maintaining sinus rhythm for patients with atrial fibrillation. Extra-cardiac side effects have been a limiting factor, especially during chronic use, and may offset its benefits. Dronedarone is a noniodinated benzofuran derivative of amiodarone that has been developed for the treatment of atrial fibrillation and atrial flutter. Similar to amiodarone, dronedarone is a potent blocker of multiple ion currents, including the rapidly activating delayed-rectifier potassium current, the slowly activating delayed-rectifier potassium current, the inward rectifier potassium current, the acetylcholine activated potassium current, peak sodium current, and L-type calcium current, and exhibits antiadrenergic effects. It has been studied for maintenance of sinus rhythm and control of ventricular response during episodes of atrial fibrillation. Dronedarone reduces mortality and morbidity in patients with high-risk atrial fibrillation, but may be unsafe in those with severe heart failure. This article will review evidence of safety and effectiveness of dronedarone in patients with atrial fibrillation

Role of antiarrhythmic drugs: frequent implantable cardioverter-defibrillator shocks, risk of proarrhythmia, and new drug therapy.

The implantable cardioverter-defibrillator (ICD) is the standard of care in patients with ischemic and nonischemic cardiomyopathy who are at high risk for arrhythmic events and sudden cardiac death. Although an ICD saves life, ICD shocks are emotionally and physically debilitating. Most patients receive adjuvant antiarrhythmic drug therapy to circumvent episodes of recurrent ventricular and supraventricular arrhythmias. Antiarrhythmic drugs including β-blockers, sotalol, amiodarone, and azimilide are effective at reducing the shock burden. This article describes data supporting the need for and potential risks and benefits of adjuvant antiarrhythmic drug therapy and examines the benefits and pitfalls of the same in ICD-implanted patients

ANTESEDEN KINERJA KARYAWAN PT BANK MALUKU DAN MALUKU UTARA CABANG AMBON

This study aims to analyze the factors that become determinants of employee performance of PT Bank Maluku and North Maluku Ambon Branch. Data were collected using questionnaires distributed to 103 employees of PT Bank Maluku and North Maluku Ambon Branch. The data collected was further processed and calculated using SPSS 21 and then analyzed using descriptive analysis and path analysis. The results show that compensation has a positive and significant influence both directly and indirectly on job satisfaction and employee performance. In addition, work motivation also has a positive and significant influence either directly or indirectly on job satisfaction and employee performance. Similarly, the work environment has a positive and significant impact on job satisfaction and employee performance either directly or indirectly. And job satisfaction has a positive and significant impact on employee performance. Furthermore, the results of this study recommend that in order to form job satisfaction and performance of employees, it is suggested that the management of PT Bank Maluku North Maluku should always pay attention to the compensation, both financial and non-financial, motivation of work, both intrinsic as well as extrinsic, and the creation of a good and conducive internal working environment.

Peran Mediasi Work Engagement terhadap Pengaruh Quality Of Work Life dan Organizational Citizenship Behavior

Penelitian ini bertujuan untuk menganalisis pengaruh quality of work life terhadap organizational citizenship behavior dengan melalui work engagement sebagai variabel pemediasi pada karyawan di CV. Saburo Ambon. Populasi dalam penelitian ini adalah seluruh karyawan yang bekerja di CV. Saburo Ambon. Sampel dalam penelitian adalah 52 orang karyawan. Metode pengumpulan data menggunakan kuesioner. Pengambilan sampel menggunakan teknik probability sampling dengan metode Simple Random Sampling. Menggunakan alat analisis SmartPLS 3.0 dengan metode analisisnya menggunakan Partial Least Square (PLS). Hasil penelitian menunjukan bahwa (1) variabel quality of work life berpengaruh positif dan signifikan terhadap organizational citizenship behavior, (2) variabel quality of work life berpengaruh positif dan signifikan terhadap work engagement, (3) variabel work engagement berpengaruh positif dan signifikan terhadap organizational citizenship behavior, (4) variabel quality of work life berpengaruh positif dan signifikan terhadap organizational citizenship behavior yang dimediasi oleh work engagement

Safety and efficacy of intravenously administered tedisamil for rapid conversion of recent-onset atrial fibrillation or atrial flutter

AbstractObjectivesThe goal of the present study was to assess the efficacy and safety of intravenous tedisamil, a new antiarrhythmic compound, for conversion of recent-onset atrial fibrillation (AF) or atrial flutter (AFL) to normal sinus rhythm (NSR).BackgroundTedisamil is a novel antiarrhythmic drug with predominantly class III activity. Its efficacy and safety for conversion of recent onset AF or AFL to NSR is not known.MethodsThis was a multicenter, double-blind, randomized, placebo-controlled, sequential ascending dose-group trial. A total of 201 patients with symptomatic AF or AFL of 3 to 48 h duration were enrolled in a two-stage study. During stage 1, patients were randomized to receive tedisamil at 0.4 mg/kg body weight or matching placebo; during stage 2, patients received tedisamil at 0.6 mg/kg body weight or matching placebo. Treatments were given as single intravenous infusions. The primary study end point consisted of the percentage of patients converting to NSR for at least 60 s within 2.5 h.ResultsOf 175 patients representing the intention-to-treat sample, conversion to NSR was observed in 41% (25/61) of the tedisamil 0.4 mg/kg group, 51% (27 of 53) of the tedisamil 0.6 mg/kg group, and 7% (4/59) of the placebo group (p < 0.001 for both tedisamil groups vs. placebo). Average time to conversion was 35 min in patients receiving tedisamil. There were two instances of self-terminating ventricular tachycardia: one episode of torsade de pointes and one of monomorphic ventricular tachycardia, both in patients receiving 0.6 mg/kg tedisamil.ConclusionsTedisamil at dosages of 0.4 and 0.6 mg/kg was superior to placebo in converting AF or AFL. Tedisamil has a rapid onset of action leading to conversion within 30 to 40 min in the majority of responders

The burden of proof: the current state of atrial fibrillation prevention and treatment trials

Atrial fibrillation (AF) is an age-related arrhythmia of enormous socioeconomic significance. In recent years, our understanding of the basic mechanisms that initiate and perpetuate AF has evolved rapidly, catheter ablation of AF has progressed from concept to reality, and recent studies suggest lifestyle modification may help prevent AF recurrence. Emerging developments in genetics, imaging, and informatics also present new opportunities for personalized care. However, considerable challenges remain. These include a paucity of studies examining AF prevention, modest efficacy of existing antiarrhythmic therapies, diverse ablation technologies and practice, and limited evidence to guide management of high-risk patients with multiple comorbidities. Studies examining the long-term effects of AF catheter ablation on morbidity and mortality outcomes are not yet completed. In many ways, further progress in the field is heavily contingent on the feasibility, capacity, and efficiency of clinical trials to incorporate the rapidly evolving knowledge base and to provide substantive evidence for novel AF therapeutic strategies. This review outlines the current state of AF prevention and treatment trials, including the foreseeable challenges, as discussed by a unique forum of clinical trialists, scientists, and regulatory representatives in a session endorsed by the Heart Rhythm Society at the 12th Global CardioVascular Clinical Trialists Forum in Washington, DC, December 3–5, 2015