Elastic and inelastic collisions of interfacial solitons and integrability of two-layer fluid system subject to horizontal vibrations

We study interfacial waves in a system of two horizontal layers of immiscible inviscid fluids involved into horizontal vibrational motion. We analyze the linear and nonlinear stability properties of the solitons in the system and consider two-soliton collision scenarios. We describe the events of explosive formation of sharp peaks on the interface, which may presumably lead to the layer rapture, and find that beyond the vicinity of this peaks the system dynamics can be represented as a kinetics of a soliton gas.Comment: 6 pages, 6 figures, to appear in Europhys. Let

Nonel approaches in the field of gastric cancer surgical treatment

The aim of the study: to estimate the impact of different cellular phenotype of gastric tumors on the survival of patients treated according to standard protocols. Object and methods of research.The work presents the results of a study conducted on the basis of two medical institutions - the National Cancer Institute and the abdominal oncology and surgery department of the Odessa Regional Oncology Center. 221 patients underwent surgery for gastric cancer (GC) in the period 2007-2013. The average age of patients was 60.88 ± 10.5 years, men - 180, women - 41. Of the total number of operated, 143 patients underwent surgery in the amount of gastrectomy, 78 - subtotal distal resection. Results. All patients included in the study underwent radical surgery. Tumors removed during surgery were examined using histological, cytological, immunohistochemical methods and genetic tests. The obtained results are monitored for the presence/absence of clinical parallels and mathematical correlations. It was concluded that some combinations of immunohistochemical (IHC) markers were effective in separating groups of patients with different biology of gastric cancer. Conclusions. Performing more advanced operations (including the use of D2 lymph dissections) is the most effective option for surgical treatment of microsatellite-unstable and Epstein-Barr virus-associated gastric cancer

Women’s Contributions to the Progress of Mathematics: Lights and Shadows

We deal with many of the notable women whose mathematical accomplishments are best appreciated through an understanding of the societies and the problems that shaped their lives. Women have participated in many of the greatest and most enduring intellectual achievements in mathematics and have enjoyed its powerful satisfactions and its aesthetics values. Not only were their intellectual investments remarkable as those of male mathematicians, but they needed an extra dimension of stamina and fortitude to cope with the prejudice against women working in hard sciences. We enjoy talking about them , because none of their lives were dull and indeed some of them were so unusual they have been romanticized. Their rich personalities and their remarkable personal lives deserve to capture our attention

Available drugs during of military state: social-economic strategies of functioning reimbursumen’t system

The Russian aggresion against Ukraine became a new reality in the XXI century and definitely shook the whole World. New realities are forcing all spheres of science and practice to work harder and develop, that is why philosophers of law are tended to call war “the driving force of progress”. Our modern life in the condition of war proves, that the technical and scientific progress as it is, is created and developed on thousands and millions of destroyed human lives. But, in order to make a warring society to move successfully forward, save as many innocent lives as possible and meet basic needs of a particularly vulnerable polutation, it is not only army, which is supposed to work for 100%, but also “home front workers” has to try harder. The current war has dimished an understanding of difference between quintiles of population, especially, if we are taking into account differences between beneficiaries of the Affordable Medicines Program (AM). At the beginning of the War, all beneficiaries of the AM, despite of level of their well-being had to suffer equally because of the short-term period of medicines’ shortage due to destroyed infrastructure of cities and regions. They were afraid that those highly necessary medicines would not return to the pharmacies neither in the sphere of the AM, nor even for normal sale. Because of the aforementioned force-majeure, most of people were not even assured that their basic needs will be met, especially were worried those ones, who have been active users of the AM for a long period of time. However, despite of the aforementioned destruction of the insfrastrucutre, the commons fears and dangers of war, the AM has not stopped working. On the contrary, it has become even more successful and progressive. The need to react quickly to the circumstances that took place, forced to achieve long-term plans of the AM creators in a very short time. Thus, the pilot program has finally fit into the general outline of the life support and health care system of Ukraine and became perhaps the most progressive in the whole Europe. But, nevertheless, the progress is definitely not standing still, the situation remains critical, the humanitarian catastrophe is becoming more and more real today, and, thus, the AM opens new promising ways of development for the coming month and years. In fact, our study was devoted to the analysis of the changes that took place since February 24, 2022, as well as promising directions for the development of AM, which are mostly dictated by the newly created humaniatrian crises in the current article.Новою реалією ХХІ століття стала загарбницька війна Росії проти України, яка без сумніву сколихнула цілий світ. Нові реалії життя змушують всі сфери науки і практики працювати у посиленому режимі та розвиватись, саме тому філософи права називають війну “рушійною силою прогресу”. Сучасне життя доводить, що технічний і науковий прогрес, як виявилось, створюється і розвивається на тисячах і мільйонах зруйнованих людських життів. Але, задля того, щоб суспільство країни, що воює, змогло рухатись далі, змогло врятувати якумога більше безвинних життів та забезпечувати базові потреби особливо вразливого контингенту населення, не тільки армія, але й “герої тилу”, тобто медики і вся система охорони здоров’я мають працювати на 100%, як це власне і відбувається зараз. Війна знизила важливість понять “квінтилі населення”, особливо якщо йдеться про прямих бенефіціарів програми “Доступні ліки”, адже серед них всі, незалежно від особистого та фінансового благополуччя, були піддані необхідності страждати від першострокової нестачі ліків, які забезпечувались програмою; були підвергнуті страху, що ці ліки не повернуться не тільки в рамках програми Доступні ліки (ДЛ), але і в принципі будуть недоступні через знищену інфраструктуру багатьох міст, а отже здійснився такий force majeure, при якому жодна людина не могла бути впевнена у власному забезпеченні навіть базових потреб, і особливо ті, хто протягом тривалого часу вже був активним користувачем ДЛ. Тим не менш, не дивлячись на вищезгадану зруйновану інфраструктуру, загальні страх і небезпеку, які приносить із собою війна, програма ДЛ не припинила свою роботу, навпаки, стала навіть більш прогресивною і успішною. Необхідність стрімко реагувати на обставини, які мали місце з погляду на війну, змусили досягнути довготривалі плани творців ДЛ за дуже короткий термін. Таким чином, пілотна програма остаточно вписалась в загальну канву системи життєзабезпечення та охорони здоров’я України і стали чи не найбільш прогресивною в цілій Європі. Але, тим не менш, прогрес безумовно не стоїть на місці, ситуація залишається критичною, гуманітарна катастрофа стає все більш реальною на сьогоднішній день, а отже ДЛ відкриває нові перспективні шляхи розвитку на найближчі місяці і роки. Власне аналізові змін, які мали місце, починаючи від 24-го лютого 2022 року, а також перспективним напрямкам розвитку ДЛ, які здебільшого продиктовані новоствореними гуманітраними кризами населення нашої країни, які мали місце через війну, і було присвячено наше дослідження, результати якого будуть освітлені у нинішній статті

The character of fracture of iron based thermal coating during fretting

The character of destruction of thermal coatings during fretting has been investigated. An iron based plasma coating has been tested with oscillation amplitude from 30 to 200 microns. The tests were conducted in air. It has been determined that the main factor influencing the rate of the wear of the coating during fretting corrosion is the size of the coating area involved into the wear process. The coating exhibits high wear resistance when the amplitude of the oscillation is commensurate with the size of the sprayed particles. During destruction of the coating the leading role belongs to fatigue-oxidation processes. The wear of the coating acquires a catastrophic character when coating macro defects - pores and interlayer boundaries - are involved into the wear process

Symmetrically coupled higher-order nonlinear Schroedinger equations: singularity analysis and integrability

The integrability of a system of two symmetrically coupled higher-order nonlinear Schr\"{o}dinger equations with parameter coefficients is tested by means of the singularity analysis. It is proven that the system passes the Painlev\'{e} test for integrability only in ten distinct cases, of which two are new. For one of the new cases, a Lax pair and a multi-field generalization are obtained; for the other one, the equations of the system are uncoupled by a nonlinear transformation.Comment: 12 pages, LaTeX2e, IOP style, final version, to appear in J.Phys.A:Math.Ge

Features of Medical Care Providing to Patients with Digestive Diseases in the Krasnodar Region during the COVID-19 Pandemic

The aim of the study: optimization the medical care provision to patients with diseases of the digestive system (DD) in the Krasnodar Region during the COVID-19 pandemic.Material and methods. The analysis of the features of the DD course in the Krasnodar Region was carried out according to the data of form C 51 “Distribution of the dead by sex, age groups and causes of death” of the Territorial Federal State Statistics Service in the Krasnodar Region, as well as monitoring the quality of medical care for patients with DD for the period from 2019 to 2021 years.Results. During the COVID-19 pandemic, the routing of gastroenterological patients, dispensary observation and preventive measures have undergone some changes. In the structure of total mortality in the Krasnodar Region, mortality from DD was 21.6 % in 2020 and 4.0 % in 2021. The decrease in the growth of mortality rate, including from DD, in the second year of the pandemic is associated with the completed healthcare systems reformatting. The increase in hospital mortality in patients with gastric and duodenal ulcers, ulcerative colitis, and diverticular disease had a significant impact on mortality rates from DD. The decreasing number of hospitalizations was explained due to the conversion of a number of hospitals into hospitals for the treatment of patients with COVID-19. The hospitalization was mainly carried out for emergency indications and patients with a more severe course of the disease. The pandemic has increased the need for telemedicine: 378 tele-consultations on the gastroenterological profile was carried out in the Krasnodar Region in 2021.Conclusion. Healthcare system workload in the Krasnodar Region increased significantly during the coronavirus pandemic that required a number of structural adjustments. In recent times, the regional health care is returning to the planned mode of providing medical care

SERUM LEVEL AND PRODUCTION OF CYTOKINES BY PBMC IN PATIENTS WITH ATOPIC DERMATITIS

The рарег presents the results of measurements of cytokine levels in serum and conditioned medium of PBMC cultures from the patients with atopic dermatitis with the exacerbation and remission in comparison with the healthy donors. We have shown that the serum levels of the key cytokines IL-5 and IL-13, proinflammatory cytokines IL-1β and IL-6 and the main Th1 cytokine — IFNγ — were higher compared to healthy donors. In the conditioned media of peripheral blood mononuclear cells in contrast, we have found a significant decrease of the spontaneous secretion of key cytokines IL-10 and IL-17. We have shown that the stimulated secretion of IL-5 and IL-13, IL-12 and INF-γ is significantly reduced in comparison with the control level. Only IL-1β revealed a statistically significant higher level of stimulated secretion without exacerbation of atopic dermatitis. The contemporary therapy has no effect on cytokine production