Long-Term Health-Related Quality of Life after Four Common Surgical Treatment Options for Breast Cancer and the Effect of Complications: A Retrospective Patient-Reported Survey among 1871 Patients

Background: Differences in quality-of-life outcomes after different surgical breast cancer treatment options, including breast reconstruction, are relevant for counseling individual patients in clinical decision-making, and for (societal) evaluations such as cost-effectiveness analyses. However, current literature shows contradictory results, because of use of different patient-reported outcome measures and study designs with limited patient numbers. The authors set out to improve this evidence using patient-reported outcome measures in a large, cross-sectional study for different surgical breast cancer treatment options. Methods: Quality of life was assessed through the EQ-5D-5L, European Organization for Research and Treatment of Cancer Quality of Life Questionnaires C30 and BR23, and the BREAST-Q. Patients with different treatments were compared after propensity-weighted adjustment of pretreatment differences. The EQ-5D was used to value the effect of surgical complications. Results: A total of 1871 breast cancer patients participated (breast-conserving surgery, n = 615; mastectomy, n = 507; autologous reconstruction, n = 330; and implant-based reconstruction, n = 419). Mastectomy patients reported the lowest EQ-5D score (mastectomy, 0.805, breast-conserving surgery, 0.844; autologous reconstruction, 0.849; and implant-based reconstruction, 0.850) and functioning scores of the C30 questionnaire. On the BREAST-Q, autologous reconstruction patients had higher mean Satisfaction with Outcome, Satisfaction with Breasts, and Sexual Well-being scores than implant-based reconstruction patients. Complications in autologous reconstruction patients resulted in a substantially lower quality of life than in implant-based reconstruction patients. Conclusions: This study shows the added value of breast conservation and reconstruction compared with mastectomy; however, differences among breastconserving surgery, implant-based reconstruction, and autologous breast reconstruction were subtle. Complications resulted in poorer health-related quality of life. (Plast. Reconstr. Surg. 146: 1, 2020.

Bestuurlijke vrijheidsbeperking van jihadisten

On 1 March 2017 the‘Temporary Law on Counterterrorism Administrative Measures’ (Wet bestuurlijke maatregelen terrorismebestrijding; hereafter: the Temporary Counterterrorism Act) came into effect, the provisions of which aim to prevent terrorist attacks primarily by reducing threats posed by the jihadist movement. The present report concerns the use in practice of the Act during the first 17 months after its entry into force, spanning the period from 1 March 2017 to 31 august 2018.This report investigates the use in actual practice of the Act based on the following questions:How frequently are the measures under the temporary Counterterrorism Act applied in practice?In how many cases have they been applied? What form of terrorist threat was identified in these cases?What were the reasons for applying the measures; what were the considerations involved?How is the application of the measures proceeding in practice

Depression in hearing-impaired children

Disorders of the head and nec

Symptoms of Psychopathology in Hearing-Impaired Children

Disorders of the head and nec

Self-Esteem in Hearing-Impaired Children: The Influence of Communication, Education, and Audiological Characteristics

Disorders of the head and nec

Behavioral problems in school-aged hearing-impaired children: the influence of sociodemographic, linguistic, and medical factors

Disorders of the head and nec

Anxiety in children with hearing aids or cochlear implants compared to normally hearing controls

Disorders of the head and nec

DECO1013:Assignment 2:Data Sonification StarCraft 2 Rank

The purpose of this sonification system is to provide an auditory representation of the points earned by me in the video game StarCraft 2 combined with my worldwide rank based on the changes in my points earned relative to the rest of the world