20 research outputs found
PARK2 loss promotes cancer progression via redox-mediated inactivation of PTEN
Get PDFCancer and Parkinson disease (PD) derive from distinct alterations in cellular processes, yet there are pathogenic mutations that are unequivocally linked to both diseases. Here we expand on our recent findings that loss of parkin RBR E3 ubiquitin protein ligase (PRKN, best known as PARK2)—which is genetically linked to PD—promotes cancer progression via redox-mediated inactivation of phosphatase and tensin homolog (PTEN) by S-nitrosylation.Institute of Cancer Research, Londo
Detection of acquired radioresistance in breast cancer cell lines using Raman spectroscopy and machine learning
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OP165 Targeted chemical analysis of the colon cancer microbiome using desorption electrospray ionisation mass spectrometry imaging (DESI-MSI)
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Identification of TC2N as a novel promising suppressor of PI3K-AKT signaling in breast cancer
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