4 research outputs found
A study of tableting materials and tablets with the retarding component containing hypromellose and carmellose sodium.
Charles University, Faculty of Pharmacy in Hradec KrálovĂ© Department: Pharmaceutical Technology Student: KristĂ˝na Koukolová Consultant: Assoc. Prof. PharmDr. Jitka MuĹľĂková, Ph.D. Title of the Diploma Thesis: A study of tableting materials and tablets with the retarding component containing hypromellose and carmellose sodium The thesis deals with the study of compressibility of directly compressible tableting materials containing coprocessed dry binders MicroceLac® 100 and Prosolv® SMCC 90 in combination with the retarding component CompactCel® SR, which is a mixture of hypromellose and carmellose sodium. The tested concentrations of the retarding component were 10 %, 20 % and 30 %. The formulations also contained salicylic acid as a model drug at concentration of 25 % and sodium stearyl fumarate as a lubricant at concentration of 1%. Flow properties, specifically fowability, apparent volumes and densities were evaluated at the tableting materials. During tablet compression, compressibility was evaluated using the energy profile of the compression process. The tested tablet parameters were tensile strength, friability, disintegration and drug dissolution. Formulations with MicroceLac® 100 showed better flow properties. The addition of a retarding component worsened the flow properties. The values...Univerzita Karlova, Farmaceutická fakulta v Hradci KrálovĂ© Katedra: Farmaceutická technologie Student: KristĂ˝na Koukolová Ĺ kolitel: doc. PharmDr. Jitka MuĹľĂková, Ph.D. Název diplomovĂ© práce: Studium tabletovin a tablet s retardujĂcĂ sloĹľkou obsahujĂcĂ hypromelosu a sodnou sĹŻl karmelosy Práce se zabĂ˝vá studiem lisovatelnosti pĹ™Ămo lisovatelnĂ˝ch tabletovin obsahujĂcĂch smÄ›sná suchá pojiva MicroceLac® 100 a Prosolv® SMCC 90 v kombinaci s retardujĂcĂ sloĹľkou CompactCel® SR, která je smÄ›sĂ hypromelosy a sodnĂ© soli karmelosy. TestovanĂ© koncentrace retardujĂcĂ sloĹľky byly 10 %, 20 % a 30 %. Tabletoviny dále obsahovaly kyselinu salicylovou jako modelovĂ© lĂ©ÄŤivo v koncentraci 25 % a mazadlo stearylfumarát sodnĂ˝ v koncentraci 1 %. U tabletovin byly hodnoceny jejich tokovĂ© vlastnosti, konktrĂ©tnÄ› jejich sypnost, zdánlivĂ© objemy a hustoty. BÄ›hem lisovánĂ tablet byla hodnocena lisovatelnost pomocĂ energetickĂ©ho profilu lisovacĂho procesu. TestovanĂ© parametry tablet byly pevnost v tahu, odÄ›r, rozpad a disoluce lĂ©ÄŤivĂ© látky z tablety. Lepšà tokovĂ© vlastnosti vykazovaly formulace s MicroceLacem® 100. PĹ™Ădavek retardujĂcĂ sloĹľky charakter toku zhoršoval. Hodnoty celkovĂ© energie lisovánĂ, energie plastickĂ© deformace i plasticity byly vyššà v pĹ™ĂpadÄ› tabletovin s Prosolvem® SMCC 90. Vlivem pĹ™Ădavku retardujĂcĂ sloĹľky...Department of Pharmaceutical TechnologyKatedra farmaceutickĂ© technologieFarmaceutická fakulta v Hradci KrálovĂ©Faculty of Pharmacy in Hradec Králov
A study of tableting materials and tablets with the retarding component containing hypromellose and carmellose sodium.
Charles University, Faculty of Pharmacy in Hradec KrálovĂ© Department: Pharmaceutical Technology Student: KristĂ˝na Koukolová Consultant: Assoc. Prof. PharmDr. Jitka MuĹľĂková, Ph.D. Title of the Diploma Thesis: A study of tableting materials and tablets with the retarding component containing hypromellose and carmellose sodium The thesis deals with the study of compressibility of directly compressible tableting materials containing coprocessed dry binders MicroceLac® 100 and Prosolv® SMCC 90 in combination with the retarding component CompactCel® SR, which is a mixture of hypromellose and carmellose sodium. The tested concentrations of the retarding component were 10 %, 20 % and 30 %. The formulations also contained salicylic acid as a model drug at concentration of 25 % and sodium stearyl fumarate as a lubricant at concentration of 1%. Flow properties, specifically fowability, apparent volumes and densities were evaluated at the tableting materials. During tablet compression, compressibility was evaluated using the energy profile of the compression process. The tested tablet parameters were tensile strength, friability, disintegration and drug dissolution. Formulations with MicroceLac® 100 showed better flow properties. The addition of a retarding component worsened the flow properties. The values..
A study of tableting materials and tablets with the retarding component containing hypromellose and carmellose sodium.
Charles University, Faculty of Pharmacy in Hradec KrálovĂ© Department: Pharmaceutical Technology Student: KristĂ˝na Koukolová Consultant: Assoc. Prof. PharmDr. Jitka MuĹľĂková, Ph.D. Title of the Diploma Thesis: A study of tableting materials and tablets with the retarding component containing hypromellose and carmellose sodium The thesis deals with the study of compressibility of directly compressible tableting materials containing coprocessed dry binders MicroceLac® 100 and Prosolv® SMCC 90 in combination with the retarding component CompactCel® SR, which is a mixture of hypromellose and carmellose sodium. The tested concentrations of the retarding component were 10 %, 20 % and 30 %. The formulations also contained salicylic acid as a model drug at concentration of 25 % and sodium stearyl fumarate as a lubricant at concentration of 1%. Flow properties, specifically fowability, apparent volumes and densities were evaluated at the tableting materials. During tablet compression, compressibility was evaluated using the energy profile of the compression process. The tested tablet parameters were tensile strength, friability, disintegration and drug dissolution. Formulations with MicroceLac® 100 showed better flow properties. The addition of a retarding component worsened the flow properties. The values...Univerzita Karlova, Farmaceutická fakulta v Hradci KrálovĂ© Katedra: Farmaceutická technologie Student: KristĂ˝na Koukolová Ĺ kolitel: doc. PharmDr. Jitka MuĹľĂková, Ph.D. Název diplomovĂ© práce: Studium tabletovin a tablet s retardujĂcĂ sloĹľkou obsahujĂcĂ hypromelosu a sodnou sĹŻl karmelosy Práce se zabĂ˝vá studiem lisovatelnosti pĹ™Ămo lisovatelnĂ˝ch tabletovin obsahujĂcĂch smÄ›sná suchá pojiva MicroceLac® 100 a Prosolv® SMCC 90 v kombinaci s retardujĂcĂ sloĹľkou CompactCel® SR, která je smÄ›sĂ hypromelosy a sodnĂ© soli karmelosy. TestovanĂ© koncentrace retardujĂcĂ sloĹľky byly 10 %, 20 % a 30 %. Tabletoviny dále obsahovaly kyselinu salicylovou jako modelovĂ© lĂ©ÄŤivo v koncentraci 25 % a mazadlo stearylfumarát sodnĂ˝ v koncentraci 1 %. U tabletovin byly hodnoceny jejich tokovĂ© vlastnosti, konktrĂ©tnÄ› jejich sypnost, zdánlivĂ© objemy a hustoty. BÄ›hem lisovánĂ tablet byla hodnocena lisovatelnost pomocĂ energetickĂ©ho profilu lisovacĂho procesu. TestovanĂ© parametry tablet byly pevnost v tahu, odÄ›r, rozpad a disoluce lĂ©ÄŤivĂ© látky z tablety. Lepšà tokovĂ© vlastnosti vykazovaly formulace s MicroceLacem® 100. PĹ™Ădavek retardujĂcĂ sloĹľky charakter toku zhoršoval. Hodnoty celkovĂ© energie lisovánĂ, energie plastickĂ© deformace i plasticity byly vyššà v pĹ™ĂpadÄ› tabletovin s Prosolvem® SMCC 90. Vlivem pĹ™Ădavku retardujĂcĂ sloĹľky...Department of Pharmaceutical TechnologyKatedra farmaceutickĂ© technologieFarmaceutická fakulta v Hradci KrálovĂ©Faculty of Pharmacy in Hradec Králov
A study of tableting materials and tablets with the retarding component containing hypromellose and carmellose sodium.
Charles University, Faculty of Pharmacy in Hradec KrálovĂ© Department: Pharmaceutical Technology Student: KristĂ˝na Koukolová Consultant: Assoc. Prof. PharmDr. Jitka MuĹľĂková, Ph.D. Title of the Diploma Thesis: A study of tableting materials and tablets with the retarding component containing hypromellose and carmellose sodium The thesis deals with the study of compressibility of directly compressible tableting materials containing coprocessed dry binders MicroceLac® 100 and Prosolv® SMCC 90 in combination with the retarding component CompactCel® SR, which is a mixture of hypromellose and carmellose sodium. The tested concentrations of the retarding component were 10 %, 20 % and 30 %. The formulations also contained salicylic acid as a model drug at concentration of 25 % and sodium stearyl fumarate as a lubricant at concentration of 1%. Flow properties, specifically fowability, apparent volumes and densities were evaluated at the tableting materials. During tablet compression, compressibility was evaluated using the energy profile of the compression process. The tested tablet parameters were tensile strength, friability, disintegration and drug dissolution. Formulations with MicroceLac® 100 showed better flow properties. The addition of a retarding component worsened the flow properties. The values..