中学校技術科「エネルギー変換に関する技術」におけるSTEM教育カリキュラムの開発

金沢大学人間社会学域学校教育学類1、研究目的日本は超高齢社会に直面し、工業、医療などの様々な分野で、将来的に新たな人材を必要数確保することが困難な状況が訪れると言われている。その中でも科学技術人材が確保できないことで、国内の経済活動や国際競争力が低下することが予測される。その対策の一つとして、科学技術人材の育成を目指したSTEM教育の実践が求められている。本研究では、中学校技術科「エネルギー変換に関する技術」の内容において、植物工場の簡易モデルをデザインするSTEM教育カリキュラムの開発を行い、科学技術人材の育成に関してどの程度寄与することができたのかを検証することを目的とした。2、研究方法現在の日本において、「STEM教育を通して何を身に付けさせるのか」、「どのような指導を行うことがSTEM教育なのか」などが明確に示されたものは管見の限りでは見られない。そこで、国内外のSTEM教育に関する文献調査と日本の社会情勢などを考慮し、現段階で考えられるSTEM教育の目的を定義することでカリキュラム開発の一助とした。また、著者らは先行研究において科学技術人材に求められる能力の一つと考えられる科学的思考を習得するプロセスを考察していることより、そのプロセスを参考にSTEM教育の学習指導法を考察した。本研究では、上記のSTEM教育の目的と学習指導法を基にカリキュラムの開発を行い、授業実践を行った。3、研究成果開発したカリキュラムの教育的効果を検証する一つとして、自由記述調査を実施した。その結果、開発したカリキュラムは、STEM教育で育成を目指す基礎的な知識の習得や科学的思考を育成することができるものであると示唆される。このことより、開発したカリキュラムはSTEM教育カリキュラムであると考えられる。開発したカリキュラムは報告書として冊子にまとめ、近隣の中学校や関係機関に配布を行う。さらに、研究結果の分析を進め、学会発表と論文の執筆を行うことで、広くSTEM教育の普及に努める。研究課題/領域番号:18H00061, 研究期間(年度):201

Implications for the Cosmic Reionization from the Optical Afterglow Spectrum of the Gamma-Ray Burst 050904 at z = 6.3

The gamma-ray burst (GRB) 050904 at z = 6.3 provides the first opportunity of probing the intergalactic medium (IGM) by GRBs at the epoch of the reionization. Here we present a spectral modeling analysis of the optical afterglow spectrum taken by the Subaru Telescope, aiming to constrain the reionization history. The spectrum shows a clear damping wing at wavelengths redward of the Lyman break, and the wing shape can be fit either by a damped Ly alpha system with a column density of log (N_HI/cm^{-2}) ~ 21.6 at a redshift close to the detected metal absorption lines (z_metal = 6.295), or by almost neutral IGM extending to a slightly higher redshift of z_{IGM,u} ~ 6.36. In the latter case, the difference from z_metal may be explained by acceleration of metal absorbing shells by the activities of the GRB or its progenitor. However, we exclude this possibility by using the light transmission feature around the Ly beta resonance, leading to a firm upper limit of z_{IGM,u} < 6.314. We then show an evidence that the IGM was largely ionized already at z=6.3, with the best-fit neutral fraction of IGM, x_HI = N_HI/N_H = 0.00, and upper limits of x_HI < 0.17 and 0.60 at 68 and 95% C.L., respectively. This is the first direct and quantitative upper limit on x_HI at z > 6. Various systematic uncertainties are examined, but none of them appears large enough to change this conclusion. To get further information on the reionization, it is important to increase the sample size of z >~ 6 GRBs, in order to find GRBs with low column densities (log N_HI <~ 20) within their host galaxies, and for statistical studies of Ly alpha line emission from host galaxies.Comment: Matches the published version in PASJ. The version with full resolution figures is available upon request to Totani or at http://www.kusastro.kyoto-u.ac.jp/~totani/up/grb050904-paper2-astroph-v3.pd

High-redshift Ly alpha emitters with a large equivalent width: Properties of i-dropout galaxies with an NB921-band depression in the Subaru Deep Field

We report new follow-up spectroscopy of i-dropout galaxies with an NB921-band depression found in the Subaru Deep Field. The NB921-depressed i-dropout selection method is expected to select galaxies with large equivalent width Ly alpha emission over a wide redshift range, 6.0<z<6.5. Two of four observed targets show a strong emission line with a clear asymmetric profile, identified as Ly alpha emitters at z=6.11 and 6.00. Their rest-frame equivalent widths are 153A and 114A, which are lower limits on the intrinsic equivalent widths. Through our spectroscopic observations (including previous ones) of NB921-depressed i-dropout galaxies, we identified 5 galaxies in total with a rest-frame equivalent width larger than 100A at 6.0<z<6.5 out of 8 photometric candidates, which suggests that the NB921-depressed i-dropout selection method is possibly an efficient way to search for Ly alpha emitters with a large Ly alpha equivalent width, in a wider redshift range than usual narrow-band excess techniques. By combining these findings with our previous observational results, we infer that the fraction of broad-band selected galaxies having a rest-frame equivalent width larger than 100A is significantly higher at z~6 (the cosmic age of ~1 Gyr) than that at z~3 (~2 Gyr), being consistent with the idea that the typical stellar population of galaxies is significantly younger at z~6 than that at z~3. The NB921-depressed i-dropout galaxies may be interesting candidates for hosts of massive, zero-metallicity Population III stars.Comment: 9 pages, 5 figures, accepted for publication in A&

Novel Variants in the CLCN1, RYR2, and DCTN1 Found in Elderly Japanese Dementia Patients: A Case Series

Dementia has an enormous impact on medical and financial resources in aging societies like Japan. Diagnosis of dementia can be made by physical and mental examinations, imaging tests, and findings of high abnormal proteins in cerebrospinal fluids. In addition, genetic tests can be performed in neurodegenerative diseases such as Alzheimer's disease (AD), frontotemporal dementia (FTD), and Parkinson's disease (PD). In this case series, we presented three cases of dementia with unknown causes who carry novel variants in the genes associated with neurodegenerative diseases. Three patients (Patients 1, 2, and 6) were found by screening 18 dementia patients using a gene panel including 63 genes. The age of onset for Patient 1 was 74 years old, and his father had PD and mother had AD. The age of onset for Patient 2 was 75 years old, and her mother had AD. The age of onset for Patient 6 was 83 years old, and her father, two sisters, and daughter had dementia. The Mini-Mental State Examination produced results of 20, 15, and 22, respectively. The suspected diagnosis by neurological examinations and imaging studies for Patients 1 and 2 was AD, and for Patient 6 was FTD. Patient 1 was treated with donepezil; Patient 2 was treated with donepezil and memantine; and Patient 6 was treated with donepezil, galantamine, and rivastigmine. The three rare variants identified were: CLCN1, encoding a chloride channel, c.2848G>A:p.Glu950Lys (Patient 1); RYR2, encoding a calcium releasing ryanodine receptor, c.13175A>G:p.Lys4392Arg (Patient 2); and DCTN1, encoding a subunit of dynactin, c. 3209G>A:p.Arg1070Gln (Patient 6). The detected variants were interpreted according to the American College of Medical Genetics (ACMG) guidelines. The minor allele frequency for each variant was 0.025%, 0.023%, and 0.0004% in East Asians, respectively. The DCTN1 variant found in Patient 6 might be associated with FTD. Although none of them were previously reported in dementia patients, all variants were classified as variants of unknown significance (VUS). Our report suggests that results of genetic tests in elderly patients with dementia need to be carefully interpreted. Further data accumulation of genotype-phenotype relationships and development of appropriate functional models are warranted

Mast Cell Infiltration is Associated with Myelofibrosis and Angiogenesis in Myelodysplastic Syndromes

Myelodysplastic syndromes are a heterogeneous group of clonal hematopoietic stem cell disorders characterized by persistent peripheral cytopenia with morphological and functional abnormalities of hematopoietic cells. Mast cells infiltrate into or around tumor tissues and play a role in remodeling of the stromal microenvironment, contributing to tumor progression. Increased mast cell numbers are associated with fibrosis, angiogenesis and a poor prognosis in human carcinomas. The aim of this study was to determine whether mast cell infiltration contributes to myelofibrosis or angiogenesis in myelodysplastic syndromes. We evaluated the correlation between mast cell density and the extent of myelofibrosis and angiogenesis in myelodysplastic syndromes. Fifty bone marrow biopsies taken from patients with a diagnosis of myelodysplastic syndromes were examined. Grading of myelofibrosis was evaluated by silver impregnation staining. Mast cell density and microvessel density were evaluated by immunohistochemistry. Human mast cells have been divided into two phenotypes. We designated a tryptase-positive mast cell as MCT and a chymase-positive mast cell as MCTC. Microvessels were identified by CD34-positive endothelial cells. Microvessel density and the extent of myelofibrosis were significantly greater in patients with high MCT and MCTC density compared to those with low MC density. Based on this, we suggest that the presence of high mast cell numbers is associated with myelofibrosis and angiogenesis in myelodysplastic syndromes

Dysregulation of RNF213 promotes cerebral hypoperfusion

RNF213 is a susceptibility gene for moyamoya disease, yet its exact functions remain unclear. To evaluate the role of RNF213 in adaptation of cerebral blood flow (CBF) under cerebral hypoperfusion, we performed bilateral common carotid artery stenosis surgery using external microcoils on Rnf213 knockout (KO) and vascular endothelial cell-specific Rnf213 mutant (human p.R4810K orthologue) transgenic (EC-Tg) mice. Temporal CBF changes were measured by arterial spin-labelling magnetic resonance imaging. In the cortical area, no significant difference in CBF was found before surgery between the genotypes. Three of eight (37.5%) KO mice died after surgery but all wild-type and EC-Tg mice survived hypoperfusion. KO mice had a significantly more severe reduction in CBF on day 7 than wild-type mice (KO, 29.7% of baseline level; wild-type, 49.3%; p = 0.038), while CBF restoration on day 28 was significantly impaired in both KO (50.0%) and EC-Tg (56.1%) mice compared with wild-type mice (69.5%; p = 0.031 and 0.037, respectively). Changes in the subcortical area also showed the same tendency as the cortical area. Additionally, histological analysis demonstrated that angiogenesis was impaired in both EC-Tg and KO mice. These results are indicative of the essential role of RNF213 in the maintenance of CBF

A Cluster of Respiratory Syncytial Virus Infections in a Hospital Ward for Adult Immunocompromised Patients

Four male patients admitted to the same ward in the first half of September 201Y were identified to have respiratory syncytial virus（RSV）infection. Their ages ranged from 49 to 85 years（median 72.5）. One patient was infected with human immunodeficiency virus and three patients had hematological malignancies. Following immuno-chromatological testing with a nasal cavity swab, RSV infection was diagnosed. Although blood and sputum cultures were performed in three patients, no significant bacteria were detected. Two cases responded to supportive therapy. However, one patient died secondary to multiple myeloma, and another patient developed pneumonia and died with an exacerbation of leukemia. RSV infections in immunocompromised hosts are associated with a poor prognosis. Early diagnosis will facilitate isolation of infected individuals to prevent hospital outbreaks