CP asymmetry and branching ratio of B -> pi pi

We investigate the branching ratios and CP asymmetries of the B -> pi pi processes measured in B factory experiments. Fits to the experimental data of this process indicate a large ratio of color-suppressed (C) to color-allowed (T) tree contributions. We investigate whether the large C/T can be explained within the QCD based model computation with i) a large effect from the end-point singularity or with ii) large final-state-interaction phase between two different isospin amplitudes. We show that the current experimental data do not exclude either possibility but we may be able to distinguish these two effects in future measurements of direct CP asymmetry of B -> pi^0 pi^0.Comment: 8 pages, 10 figure

Coulomb Oscillations in Antidots in the Integer and Fractional Quantum Hall Regimes

We report measurements of resistance oscillations in micron-scale antidots in both the integer and fractional quantum Hall regimes. In the integer regime, we conclude that oscillations are of the Coulomb type from the scaling of magnetic field period with the number of edges bound to the antidot. Based on both gate-voltage and field periods, we find at filling factor {\nu} = 2 a tunneling charge of e and two charged edges. Generalizing this picture to the fractional regime, we find (again, based on field and gate-voltage periods) at {\nu} = 2/3 a tunneling charge of (2/3)e and a single charged edge.Comment: related papers at http://marcuslab.harvard.ed

AAA gunnermodel based on observer theory

The Luenberger observer theory is used to develop a predictive model of a gunner's tracking response in antiaircraft artillery systems. This model is composed of an observer, a feedback controller and a remnant element. An important feature of the model is that the structure is simple, hence a computer simulation requires only a short execution time. A parameter identification program based on the least squares curve fitting method and the Gauss Newton gradient algorithm is developed to determine the parameter values of the gunner model. Thus, a systematic procedure exists for identifying model parameters for a given antiaircraft tracking task. Model predictions of tracking errors are compared with human tracking data obtained from manned simulation experiments. Model predictions are in excellent agreement with the empirical data for several flyby and maneuvering target trajectories

Modeling reciprocal effects in medical research: critical discussion on the current practices and potential alternative models

Longitudinal designs provide a strong inferential basis for uncovering reciprocal effects or causality between variables. For this analytic purpose, a cross-lagged panel model (CLPM) has been widely used in medical research, but the use of the CLPM has recently been criticized in methodological literature because parameter estimates in the CLPM conflate between-person and within-person processes. The aim of this study is to present some alternative models of the CLPM that can be used to examine reciprocal effects, and to illustrate potential consequences of ignoring the issue. A literature search, case studies, and simulation studies are used for this purpose. We examined more than 300 medical papers published since 2009 that applied cross-lagged longitudinal models, finding that in all studies only a single model (typically the CLPM) was performed and potential alternative models were not considered to test reciprocal effects. In 49% of the studies, only two time points were used, which makes it impossible to test alternative models. Case studies and simulation studies showed that the CLPM and alternative models often produce different (or even inconsistent) parameter estimates for reciprocal effects, suggesting that research that relies only on the CLPM may draw erroneous conclusions about the presence, predominance, and sign of reciprocal effects. Simulation studies also showed that alternative models are sometimes susceptible to improper solutions, even when reseachers do not misspecify the model

The contribution of lesion location to upper limb deficit after stroke

BACKGROUND: Motor deficit after stroke is related to regional anatomical damage. OBJECTIVE: To examine the influence of lesion location on upper limb motor deficit in chronic patients with stroke. METHODS: Lesion likelihood maps were created from T1-weighted structural MRI in 33 chronic patients with stroke with either purely subcortical lesions (SC, n=19) or lesions extending to any of the cortical motor areas (CM, n=14). We estimated lesion likelihood maps over the whole brain and applied multivoxel pattern analysis to seek the contribution weight of lesion likelihood to upper limb motor deficit. Among 5 brain regions of interest, the brain region with the greatest contribution to motor deficit was determined for each subgroup. RESULTS: The corticospinal tract was most likely to be damaged in both subgroups. However, while damage in the corticospinal tract was the best indicator of motor deficit in the SC patients, motor deficit in the CM patients was best explained by damage in brain areas activated during handgrip. CONCLUSIONS: Quantification of structural damage can add to models explaining motor outcome after stroke, but assessment of corticospinal tract damage alone is unlikely to be sufficient when considering patients with stroke with a wide range of lesion topography

Weighted coverage based reviewer assignment

Peer reviewing is a standard process for assessing the quality of submissions at academic conferences and journals. A very important task in this process is the assignment of reviewers to papers. However, achieving an appropriate assignment is not easy, because all reviewers should have similar load and the subjects of the assigned papers should be consistent with the reviewers' expertise. In this paper, we propose a generalized framework for fair reviewer assignment. We first extract the domain knowledge from the reviewers' published papers and model this knowledge as a set of topics. Then, we perform a group assignment of reviewers to papers, which is a generalization of the classic Reviewer Assignment Problem (RAP), considering the relevance of the papers to topics as weights. We study a special case of the problem, where reviewers are to be found for just one paper (Journal Assignment Problem) and propose an exact algorithm which is fast in practice, as opposed to brute-force solutions. For the general case of having to assign multiple papers, which is too hard to be solved exactly, we propose a greedy algorithm that achieves a 1/2-approximation ratio compared to the exact solution. This is a great improvement compared to the 1/3-approximation solution proposed in previous work for the simpler coverage-based reviewer assignment problem, where there are no weights on topics. We theoretically prove the approximation bound of our solution and experimentally show that it is superior to the current state-of-the-art.postprin

Can fully automated detection of corticospinal tract damage be used in stroke patients?

We compared manual infarct definition, which is time-consuming and open to bias, with an automated abnormal tissue detection method in measuring corticospinal tract-infarct overlap volumes in chronic stroke patients to help predict motor outcome

Assessing a standardised approach to measuring corticospinal integrity after stroke with DTI

The structural integrity of the corticospinal tract (CST) after stroke is closely linked to the degree of motor impairment. Simple and reliable methods of assessing white matter integrity within the CST would facilitate the use of this measure in routine clinical practice. Commonly, diffusion tensor imaging is used to measure voxel-wise fractional anisotropy (FA) in a variety of regions of interest (ROIs) representing the CST. Several methods are currently in use with no consensus about which approach is best. ROIs are usually either the whole CST or the posterior limb of the internal capsule (PLIC). These are created manually on brain images or with reference to an individual's CST determined by tractography. Once the ROI has been defined, the FA can be reported as an absolute measure from the ipsilesional side or as a ratio in comparison to the contralesional side. Both corticospinal tracking and manual ROI definition in individual stroke patients are time consuming and subject to bias. Here, we investigated whether using a CST template derived from healthy volunteers was a feasible method for defining the appropriate ROI within which to measure changes in FA. We reconstructed the CST connecting the primary motor cortex to the ipsilateral pons in 23 age-matched control subjects and 21 stroke patients. An average healthy CST template was created from the 23 control subjects. For each patient, FA values were then calculated for both the template CST and for their own CST. We compared patients' FA metrics between the two tracts by considering four measures (FA in the ipsilesional side, FA in the contralesional side, FA ratio of the ipsilesional side to the contralesional side and FA asymmetry between the two sides) and in two tract-based ROIs (whole tract and tract section traversing the PLIC). There were no significant differences in FA metrics for either method, except for contralesional FA. Furthermore, we found that FA metrics relating to CST damage all correlated with motor ability post-stroke equally well. These results suggest that the healthy CST template could be a surrogate structure for defining tract-based ROIs with which to measure stroke patients' FA metrics, avoiding the necessity for CST tracking in individual patients. CST template-based automated quantification of structural integrity would greatly facilitate implementation of practical clinical applications of diffusion tensor imaging