13 research outputs found
Photodynamic therapy of choroidal neovascularization with enlargement of the spot size to include the feeding complex
This is a case report of a 83-year-old man with choroidal neovascularization (CNV), due to age-related macular degeneration (AMD) in his right eye. Digital fluorescein (FA) and indocyanine green angiography (ICG) were performed, which disclosed predominantly classic subfoveal CNV and a dilated and tortuous feeding complex. The visual acuity was 20/800. Anti-vascular endothelial growth factor (anti-VEGF) treatment was suggested, however, the patient was not keen to receive an intraocular injection. Modified photodynamic therapy (PDT) with spot size enlarged, to include not only the CNV lesion but the feeding complex as well, was performed. Ten days after one session of PDT, ICG showed absence of leakage from the CNV and complete occlusion of the feeding complex. The visual acuity gradually improved to 20/100 and remained stable during the following 23 months. No evidence of CNV leakage was seen in the FA and ICG during the follow up period. Adjustment of the PDT spot size to include the detectable by ICG feeding complex might be an additional option in order to close the subfoveal CNV and might be considered as an alternative to intravitreal injection of anti-VEGF in selected cases where anti-VEGF treatment is not available
Skin rash associated with intravitreal bevacizumab in a patient with macular choroidal neovascularization
Ioannis D Ladas, Marilita M Moschos, Thanos D Papakostas, Athanasios I Kotsolis, Ilias Georgalas, Michail ApostolopoulosDepartment of Ophthalmology, “G. Gennimatas” Hospital of Athens, University of Athens, Athens, GreecePurpose: The purpose of this observational case report is to describe a case of skin rash after intravitreal use of bevacizumab.Methods: A 50-year-old man with choroidal neovascularization in the right eye due to age-related macular degeneration was treated with three intravitreal injections of bevacizumab.Results: Twelve days after the first injection, the patient developed a maculopapular rash on his forehead and on both temporal regions around his eyes. The rash disappeared eight days after treatment with topical corticosteroids. A skin rash with the same distribution reappeared 14 days after the second and 10 days after the third injection. Similarly, it disappeared five and seven days after the use of the same treatment. The follow-up period was 15 months after the third injection. During the follow-up period the rash did not reappear.Conclusion: This case report may initiate further investigation of similar cases to support this observation, as there are a lack of reports of skin rash after intravitreal administration of bevacizumab.Keywords: skin rash, bevacizumab, age-related macular degeneratio
Fluorescein angiography and optical coherence tomography concordance for choroidal neovascularisation in multifocal choroidtis
Purpose To compare the utility of fluorescein angiography (FA) and
optical coherence tomography (OCT) as diagnostic adjuncts in evaluating
symptomatic patients with choroidal neovascularisation (CNV) due to
multifocal choroiditis (MFC).
Methods Patients with CNV due to MFC were retrospectively evaluated in a
consecutive fashion. Fundus photography, FA, OCT and biomicroscopy were
used to establish the diagnosis. Primary outcome measures included CNV
classification (type 1 or occult and type 2 or classic) location and the
associated FA and OCT findings.
Results Twenty eyes from 17 patients were included in the study. In 19
eyes (95%) the FA revealed CNV type 2; in one eye (5%) the type of CNV
was indeterminate due to a subretinal haemorrhage that covered the
lesion. Thirteen eyes had OCT imaging and all revealed hyper-reflectance
beneath the neurosensory retina. However, only 53.8% revealed
subretinal fluid (SRF) or intraretinal cystic abnormalities.
Conclusions The CNV in MFC is virtually always type 2, or so-called
classic CNV, with vessels beneath the neurosensory retina. Except when
blocked by subretinal blood, the neovascularisation is clearly
demonstrated by FA. In contrast, only 53.8% of these eyes showed clear
evidence of actively proliferating neovascularisation on OCT. Therefore,
eyes suspected of having CNV in MFC should be evaluated with FA
RANIBIZUMAB FOR THE TREATMENT OF EXUDATIVE AGE-RELATED MACULAR DEGENERATION ASSOCIATED WITH RETINAL PIGMENT EPITHELIAL TEAR
Purpose: To evaluate the efficacy of intravitreal ranibizumab in eyes
with exudative age-related macular degeneration associated with retinal
pigment epithelial tear.
Methods: In this retrospective case series, patients with active
exudative age-related macular degeneration associated with retinal
pigment epithelial tear were treated by repeated injections of
intravitreal ranibizumab. The outcome measures were best-corrected
visual acuity and the signs of lesion activity, as evaluated by optical
coherence tomography, fluorescein angiography, and indocyanine green
angiography.
Results: Twenty-one eyes of 20 patients were followed-up for a median of
12 months (range, 6-28 months). The median number of injections was 7
(range, 3-15). The best-corrected visual acuity improved in 6 eyes
(28.57%), remained stable in 12 (57.14%), and decreased in 3
(14.28%). At the end of the follow-up time, 19 eyes (90.47%) had an
inactive neovascular lesion in angiography, while 18 eyes (85.71%) had
no signs of intraretinal or subretinal fluid.
Conclusion: Intravitreal ranibizumab was effective in improving or
stabilizing vision and resulting in a quiescent lesion in the majority
of patients with exudative age-related macular degeneration associated
with retinal pigment epithelial tear. The functional results were
apparently better in eyes without foveal involvement by the retinal
pigment epithelial tear. RETINA 31:1083-1088, 201
Efficacy of photodynamic therapy in the management of occult choroidal Neovascularization associated with serous pigment epithelium detachment
Aims: To evaluate the efficacy of photodynamic therapy (PDT) in the
treatment of subfoveal occult choroidal neovascularization (CNV)
associated with serous pigment epithelium detachment (PED) in eyes with
age-related macular degeneration. Methods: Hundred and fifty-three
patients ( 161 eyes) with subfoveal occult CNV due to age-related
macular degeneration, were divided into two groups. The first group (70
patients, 75 eyes) included eyes with occult CNV associated with serous
PED of at least 1 disc diameter in size and the second (83 patients, 86
eyes) eyes with late leakage of undetermined source. All the patients
were treated with PDT. The follow-up time ranged from 12 to 48 months.
Results: At the last examination, in the first group, the visual acuity
(VA) improved or remained stable in 17 (22.7%) and decreased in 58
(77.3%). In the second group, the VA improved or remained stable in 37
(43%) and decreased in 49 (57%). The difference in the change
(decrease) in the VA between the two groups was statistically very
significant (p = 0.0075). Retinal pigment epithelium tear occurred in 15
eyes (20%) of the first group. Conclusion: Our study showed that the
visual prognosis of eyes treated with PDT due to subfoveal occult CNV
associated with serous PED is not favorable. We believe that the
distinction between the two forms of occult CNV is essential, as they
carry a different prognosis. Copyright (c) 2007 S. Karger AG, Basel
SAFETY OF REPEAT INTRAVITREAL INJECTIONS OF BEVACIZUMAB VERSUS RANIBIZUMAB Our Experience After 2,000 Injections
Purpose: To compare the safety of repeat intravitreal injections of
bevacizumab versus ranibizumab performed on a large series of patients
during the past 2 years period of time.
Methods: Four hundred fifty patients receiving 2,000 injections (1,275
bevacizumab and 725 ranibizumab) were studied retrospectively.
Injections performed in a usual examination room under the standard
sterile conditions. Follow-up varied from 3 to 24 months.
Results: Serious ocular adverse events were uncommon. Only one patient
developed retinal detachment (0.05%). Most common procedure-related
ocular adverse event was injection-site redness (64.75%). Postoperative
subconjuctival hemorrhage occurred after 200 (10%) injections. Patients
receiving aspirin treatment were more prone to have subconjuctival
hemorrhage (P = 0.0002). Most common drug-related ocular adverse event
was uveitis (1.90%), which was treated successfully and lasted no > 12
days. There was no statistically significant difference between the
patients treated with bevacizumab or ranibizumab regarding the noted
adverse events (P > 0.5%).
Conclusion: Multiple intravitreal injections of bevacizumab or
ranibizumab were both well tolerated and safe. Performing injections on
a usual examination room proved safe. Injection-site redness,
subconjuctival hemorrhage, and uveitis were the most common ocular
adverse events. Aspirin treatment was a risk factor for the development
of subconjuctival hemorrhage
Intravitreal bevacizumab combined with photodynamic therapy for the treatment of occult choroidal neovascularization associated with serous pigment epithelium detachment in age-related macular degeneration
Purpose: To evaluate the efficacy of intravitreal injection of
bevacizurnab combined with photodynamic therapy (PDT) for the treatment
of occult choroidal neovascularization (CNV) associated with serous
pigment epithelium detachment (s-PED) due to age-related macular
degeneration (AMD).
Methods: In this retrospective study, six patients (six eyes) with
subfoveal occult CNV associated with s-PED due to AMD were treated with
intravitreal bevacizurnab combined with PDT. All patients were treated
at baseline with PDT followed by intravitreal bevacizumab 1.25 mg 1 hour
later. Afterwards, according to the findings of optical coherence
tomography and fluorescein angiography, repeat bevacizurnab injections
were given, if necessary, monthly for three doses followed by further
doses every 3 months. PDT was repeated every 3 months according to the
same criteria. Follow-up time was 9 months.
Results: All patients completed their treatment during the first 3
months from baseline. Best-corrected visual acuity (BCVA) improved or
remained stable related to the baseline values in all patients at the
end of the follow-up time. Mean BCVA improved from 20/67 to 20/42. S-PED
and subretinal fluid decreased or disappeared. The mean central 1-mm
retinal thickness was reduced from baseline value for the 9-month
follow-up period by 128 mu m.
Conclusion: Intravitreal bevacizumab combined with PDT seems to be a
promising treatment with good functional and anatomical results for
occult CNV associated with s-PED due to AMD