Children, insanity and child psychiatry c.1800-1935

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Bachelard, by Vincent Bontems, Paris, Belles Lettres, 2010

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Is there such a thing as ‘Greek atomism’?

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Expression of Soluble Form of Aurora A as a Predictive Factor for Neoadjuvant Therapy in Breast Cancer Patients: A Single-Center Pilot Study

Purpose: To search for new predictive breast cancer biomarkers. We analyzed the serum concentrations of biomarkers involved in carcinogenesis, which can also be targeted by therapy. Methods: In a single-center prospective study, the serum levels of Aurora A, thymidine kinase 1, and human epidermal growth factor receptor type 3 (HER3) were determined in 119 women with BC before neoadjuvant treatment using ELISA kits. Results: The following clinical data were analyzed: age; TNM; the expression of ER, PGR, HER2, and Ki67; histological grade (G); and the response to neoadjuvant treatment (NAT) in the residual tumor burden classification (RCB). A complete pathological response (pCR) was achieved after NAT in 41 patients (34%). The highest proportion of the patients with a confirmed pCR was found for triple negative breast cancer (TNBC) (62.5%); non-luminal HER2-positive (52.6%) cancer subtypes (p = 0.0003); and in the G3 group (50%; p = 0.0078). The patients with higher levels of Aurora A were more likely to achieve pCR (p = 0.039). In the multivariate analysis, the serum Aurora A levels ≥ 4.75 ng/mL correlated with a higher rate of pCR (OR: 3.5; 95% CI: 1.2–10.1; p = 0.023). Conclusions: We showed that in a biologically heterogeneous group of BC patients, the pretreatment serum Aurora A levels were of significant value in predicting the response to NAT

Effects of feeding whole-grain triticale and sex on carcass and meat characteristics of common pheasants

The aim of the present research has been to determine the effect of replacing a part of commercial compound feed with whole triticale grain on the body weight (BW), body measurements, feed conversion ratio (FCR), carcass composition and meat quality of pheasants. The study involved 80 one-d-old common pheasants. From 71 to 112 d of rearing, two diets were administered: a complete commercial diet ad libitum for control pheasants and restricted amounts of a commercial diet (50%) and whole triticale grain (50%) for experimental pheasants. Each treatment consisted of 4 replications, 10 birds each. Introducing whole triticale grain did not cause significant changes in BW, body measurements, feed intake and FCR. The carcasses of 112-d-old pheasants fed whole triticale grain diet showed a significantly lower breast muscle content (%) and a significantly higher content of skin with subcutaneous fat and carcass remainders (p < .05). Breast muscles of pheasants fed commercial compound feed and whole triticale grain exhibited significantly higher hardness, chewiness and gumminess, more palmitic acid and zinc, as well as significantly less sodium, water, linoleic acid, paullinic acid, heptadeconoic acid. There were also significant changes in water and protein, the content of fatty acids in leg muscles, except for myristic acid, pentadecanoic acid, arachidonic acid and nervonic acid. Irrespective of the type of diet, males showed a significantly higher body weight, body measurements and carcass weight, and their breast muscles demonstrated significantly higher WB shear force and the amounts of protein, linoleic acid, potassium, phosphorus, magnesium and zinc

Inclusion and exclusion criteria.

BackgroundCardiological complications of oncological treatment, including the most serious one, heart failure, constitute a significant and still unsolved clinical problem. A history of dyslipidemia and complications of atherosclerosis, including coronary artery disease, are established risk factors for cardiotoxicity in cancer patients. In recent years, a protective effect of statin treatment on the development of heart failure in cancer patients has been observed. This protocol describes a study aiming to assess the prognostic value of coronary atherosclerosis burden and the CAC score on the onset of cardiac dysfunction associated with cancer therapy.MethodsANTEC (Atherosclerosis iN chemoTherapy-rElated Cardiotoxicity) is a single-site, prospective, observational study to evaluate the influence of the coronary atherosclerosis and CAC score assessed by computed tomography on the development of left ventricular systolic dysfunction in cancer patients with at least moderate cardiotoxicity risk. A group of 80 patients diagnosed with cancer prior to high-dose anthracycline chemotherapy (doxorubicin ≥ 240 mg / m2 body weight or epirubicin ≥ 600 mg / m2 body weight), without a history of heart failure and coronary artery disease, will be included in the study. Patient follow-up is planned for 12 months. In all patients, coronary computed tomographic angiography (CCTA) will be performed once at the beginning of the study. The primary endpoint is the onset of cancer therapy-related cardiovascular toxicity, defined as mild, moderate, severe and very severe according to ESC 2022 Cardio-oncology guidelines. During follow up, echocardiography with GLS assessment will be performed every three months. Additionally, new biomarkers of atherosclerosis (IL-6, MPO, TNF-alpha) will be measured every 6 months. The study registration identifier on clinicaltrials.gov is NCT05118178.Clinical trials registryThis study is listed on cinicaltrials.gov with identifier NCT05118178.</div