The Effect of Reagents Mimicking Oxidative Stress on Fibrinogen Function

Fibrinogen is one of the plasma proteins most susceptible to oxidative modification. It has been suggested that modification of fibrinogen may cause thrombotic/bleeding complications associated with many pathophysiological states of organism. We exposed fibrinogen molecules to three different modification reagents—malondialdehyde, sodium hypochlorite, and peroxynitrite—that are presented to various degrees in different stages of oxidative stress. We studied the changes in fibrin network formation and platelet interactions with modified fibrinogens under flow conditions. The fastest modification of fibrinogen was caused by hypochlorite. Fibers from fibrinogen modified with either reagent were thinner in comparison with control fibers. We found that platelet dynamic adhesion was significantly lower on fibrinogen modified with malondialdehyde and significantly higher on fibrinogen modified either with hypochlorite or peroxynitrite reflecting different prothrombotic/antithrombotic properties of oxidatively modified fibrinogens. It seems that, in the complex reactions ongoing in living organisms at conditions of oxidation stress, hypochlorite modifies proteins (e.g., fibrinogen) faster and more preferentially than malondialdehyde. It suggests that the prothrombotic effects of prior fibrinogen modifications may outweigh the antithrombotic effect of malondialdehyde-modified fibrinogen in real living systems

Theories of intelligence and their significance for educational theory and practice

The thesis deals with theories of intelligence and their significance for pedagogical theory and practice. The first part of the thesis describes theories of intelligence, specific theories of intelligence, mental retardation, causes of mental retardation, and focus on the relationship between theories of intelligence and pedagogical theory and practice. The second section presents an overview of current educational theories and practices, the education of gifted children and education of mentally retarded children. The last part deals with the range of leisure activities for gifted children and children with mental disabilities

Využití Topic Maps pro zlepšení navigace na webu

Cílem této bakalářské práce je navrhnout a prototypově implementovat řešení využívající Topic Maps pro navigaci na webových stránkách. Jejím výsledkem je pak aplikace postavená na spojení tohoto relativně nového mezinárodního standardu pro organizování znalostí a populárního řešení poskytování webových stránek softwarovou architekturou LAMP

Dynamic web pages

Serving dynamic web pages raises higher load of web servers and associated technologies. This can to some extent eliminate setting up reverse proxy with cache in front of the web server. The primary goal of this thesis is to implement this technique via presently most popular web server -- Apache. These Apache's proxy features were at first well tested and described, later practically applied in real LAMP software bundle enviroment (Linux, Apache, PHP, MySQL).Diplomová práce se zabývá problematikou dynamicky zasílaných WWW stránek. Jejich použití, hlavně u velmi zatížených webových aplikací, přináší kromě nesporných výhod pro uživatele i některé nevýhody z hlediska výkonu serverů a souvisejících technologií. K řešení některých z nich lze využít zpětných proxy serverů. Cílem bylo zprovoznit reverzní proxy server s meziukládáním v prostředí dnes nejpopulárnějšího webového serveru -- Apache. Tento přístup je v práci nejprve podrobně popsán i otestován, následně je prověřen v praxi na vytíženém webovém sídle. Prostředím pro testování i realizaci praktické části byla populární platforma poskytování dynamicky generovaných internetových stránek LAMP (Linux, Apache, PHP,MySQL)

Dynamic web pages

Serving dynamic web pages raises higher load of web servers and associated technologies. This can to some extent eliminate setting up reverse proxy with cache in front of the web server. The primary goal of this thesis is to implement this technique via presently most popular web server -- Apache. These Apache's proxy features were at first well tested and described, later practically applied in real LAMP software bundle enviroment (Linux, Apache, PHP, MySQL)

Využití Topic Maps pro zlepšení navigace na webu

Cílem této bakalářské práce je navrhnout a prototypově implementovat řešení využívající Topic Maps pro navigaci na webových stránkách. Jejím výsledkem je pak aplikace postavená na spojení tohoto relativně nového mezinárodního standardu pro organizování znalostí a populárního řešení poskytování webových stránek softwarovou architekturou LAMP

Evaluation of Great Cormorant predation activities (Phalacrocorax carbo sinensis) during the spring and autumn migration to ponds on School´s Piscicapture in Protivín between the years 2009-2011

Evaluation of Great Cormorant predation activities (Phalacrocorax carbo sinensis) during the spring and autumn migration to ponds on School´s Piscicapture in Protivín between the years 2009 - 2011 and compensation for damages in accordance to the law No. 115/2000 Coll. I compared the results of self-monitoring with the majority known information from many sources in the literature and confirmed the fact that predation pressure are frequently exposed those ponds which are providing food supply in the form of dense fish stock with an acceptable piece weighing 0.03 to 0.5 kg independently on the size of the pond. Confirmed facts are exposed to the conclusion on today's constantly evolving legislation allowing compensation for damages caused by Great cormorant - Act No. 115/2000 Coll. versus regulations No. 393/2012 Coll. and No. 432/2005 Coll

Testing of odour fences as protecting measure against otter on small ponds of fisheries KŠH ČB, Protivín and opinion with compensation of damages after law N.115/2000Sb.

The presented diploma thesis deals with the current issue of compensation for damages caused by European otter (Lutra lutra), namely the use of feasible preventive measures to eliminate damages and to ensure the entitlement to compensation in accordance with the law No 115/2000 Col. It also presents the results of practical testing of scent barrier systems as an alternative protective equipment agains unwanted predation in real conditions of fish storage pools