Carbon Nanotube based approach on FETs using Ternary Comparator

A Carbon Nanotube Field Effect Transistor (CNFET) is referred to as a FET that utilizes a single Carbon Nanotube or an array of carbon nanotubes as the channel material instead of bulk silicon in the traditional MOSFET structure. New approach of ternary magnitude comparator based on the CNFET ternary logic gates. These gates are promising alternative to conventional logic design because of its energy efficiency, it can accomplish by the reduced circuit on ternary logic. Ternary comparator implementation is based on prefix based design and combines ternary and binary logic gates for optimized implementation. A novel approach of a comparator has been implemented and simulated using SPICE. A design response indicates that the 1-bit comparator consumes less power say 0.65µW and has a delay of 21ps. The simulation results for comparators with versatile lengths of operands

Fermented wheat germ extract - nutritional supplement or anticancer drug?

<p>Abstract</p> <p>Background</p> <p>Fermented wheat germ extract (FWGE) is a multisubstance composition and, besides others, contains 2-methoxy benzoquinone and 2, 6-dimethoxy benzoquinone which are likely to exert some of its biological effects. FWGE interferes with anaerobic glycolysis, pentose cycle and ribonucleotide reductase. It has significant antiproliferative effects and kills tumor cells by the induction of apoptosis via the caspase-poly [ADP-ribose] polymerase-pathway. FWGE interacts synergistically with a variety of different anticancer drugs and exerted antimetastatic properties in mouse models. In addition, FWGE modulates immune response by downregulation of MHC-I complex and the induction of TNF-α and various interleukins. Data in the F-344 rat model provide evidence for a colon cancer preventing effect of FWGE.</p> <p>Clinical data from a randomized phase II trial in melanoma patients indicate a significant benefit for patients treated with dacarbazine in combination with FWGE in terms of progression free survival (PFS) and overall survival (OS). Similarly, data from studies in colorectal cancer suggested a benefit of FWGE treatment. Besides extension of OS and PFS, FWGE improved the quality of life in several studies.</p> <p>Conclusion</p> <p>In conclusion, available data so far, justify the use of FWGE as a non-prescription medical nutriment for cancer patients. Further randomized, controlled and large scale clinical studies are mandatory, to further clarify the value of FWGE as a drug component of future chemotherapy regimens.</p

An Efficient Cardiac Signal enhancement using Time-Frequency Realization of leaky Adaptive Noise Cancelers for Remote heath monitoring systems

Nowadays telecardiology is an important tool in cardiac diagnosis from a remote location. During Electrocardiogram (ECG) or Cardiac Signal acquisition several artifacts strongly affect the ST segment, degrade the signal quality, frequency resolution, produce large amplitude signals in ECG that can resemble PQRST waveforms and mask the tiny features that are important for clinical monitoring and diagnosis. So the extraction of high-resolution cardiac signals from recordings contaminated with artifacts is an important issue to investigate. In this paper, various novel block based time–frequency domain adaptive filter structures for cardiac signal enhancement are presented. These filters estimate the deterministic components of the cardiac signal and remove the noise component. The Block Leaky Least Mean Square (BLLMS) algorithm, being the solution of the steepest descent strategy for minimizing the mean squared error in a complete signal occurrence, is shown to be steady-state unbiased and with a lower variance than the LMS algorithm. To improve the filtering capability some variants of BLLMS, Block Normalized LLMS (BNLLMS) and Block Error Normalized LLMS (BENLLMS) algorithms are implemented in both time domain (TD) and frequency domains (FD). Finally, we have applied these algorithms on real cardiac signals obtained from the MIT-BIH data base and compared their performance with the conventional LLMS algorithm. The results show that the performance of the block based algorithms is superior to the LLMS counterparts in terms of signal to noise ratio improvement (SNRI), excess mean square error (EMSE) and misadjustment (M). Among all the algorithms FDBENLLMS achieves higher SNRI than other techniques. These values are 25.8713 dB, 20.1548 dB, 21.6718 dB and 20.7131 dBs for power line interference (PLI), baseline wander (BW), muscle artifacts (MA) and electrode motion artifacts (EM) removal

Efficient block processing of long duration biotelemetric brain data for health care monitoring

In real time clinical environment, the brain signals which doctor need to analyze are usually very long. Such a scenario can be made simple by partitioning the input signal into several blocks and applying signal conditioning. This paper presents various block based adaptive filter structures for obtaining high resolution electroencephalogram (EEG) signals, which estimate the deterministic components of the EEG signal by removing noise. To process these long duration signals, we propose Time domain Block Least Mean Square (TDBLMS) algorithm for brain signal enhancement. In order to improve filtering capability, we introduce normalization in the weight update recursion of TDBLMS, which results TD-B-normalized-least mean square (LMS). To increase accuracy and resolution in the proposed noise cancelers, we implement the time domain cancelers in frequency domain which results frequency domain TDBLMS and FD-B-Normalized-LMS. Finally, we have applied these algorithms on real EEG signals obtained from human using Emotive Epoc EEG recorder and compared their performance with the conventional LMS algorithm. The results show that the performance of the block based algorithms is superior to the LMS counter-parts in terms of signal to noise ratio, convergence rate, excess mean square error, misadjustment, and coherence

Suzuki‐Miyaura cross–coupling reaction in water: facile synthesis of (hetero) aryl uracil bases using pot assium organo trifluoroborates under microwave irradiation.

In this paper, we report the use of (hetero) aryl potassiumorganotrifluoroborate salts as versatile nucleophilic organoboron reagents in the Suzuki‐Miyaura cross‐coupling reaction of an electron rich 6‐chloro 3‐methyl uracil in water under microwave irradiation. A comparative study of the cross‐coupling reaction of this chloro uracil analogue with different nucleophilic organoboron source revealed the superior reactivity of (hetero) aryl potassiumorganotrifluoroborates in water under microwave irradiation. Diversely functionalised (hetero) aryl uracil bases, which are known possess a wide range of applications in chemical biology, were efficiently synthesized using this optimised protocol

Synthesis of some novel piperidine fused 5-thioxo-1H-1,2,4-triazoles as potential antimicrobial and antitubercular agents

A novel series of analogues based on 5-(1-(4-chloro-3-methoxyphenyl)piperidin-4-yl)-4-phenyl-2H-1,2,4-triazol e-3(4H)-thione core have been synthesized and their potential as antibacterial, antifungal and antitubercular agents was examined. The structure-activity relationship (SAR) studies of these derivatives 5 (a-k) clearly indicate the vital role of lipophilicity as a major factor in enhancing the biological activity of these compounds. Among the compounds screened, 5a, 5c, 5d, 5j and 5k displayed significant activity against Mycobacterium tuberculosis H37Rv strain.Graphic abstrac