Chemical-induced polyneuropathy in children with oncohematological pathology

The paper presents an analysis of clinical and instrumental studies of patients with chemo-induced peripheral neuropathyВ работе представлен анализ клинических и инструментальных исследований пациентов с химио-индуцированной полинейропатией

Neurosurgery departments statistics of city clinical hospital in the children's age group from 2016 to 2018

This article presents data that provide an idea of the structure and volume of surgical care for the children's age group of the population provided in the neurosurgical departments of the CCH № 40 from 2016 to 2018.В данной статье изложены данные, которые дают представление о структуре и объеме хирургической помощи детской возрастной группе населения, оказанной в нейрохирургических отделениях ГКБ № 40 с 2016 по 2018 год

Analysis of the activities of the student scientific circle of neurology, neurosurgery and medical genetics for the period of 2016-2018 academic years

The article describes the activity indicators of the student's scientific circle in neurology.В статье рассмотрены показатели активности студенческого научного кружка по неврологи

Clinical case of autosomo-dominant Dopa-responsive torsion dystonia

The article describes a clinical case of an autosomal dominant dopa-responsive torsion dystonia, analyzes the pedigree, differentiate the features of the debut of the disease in the family. Also the neurological status described of a particular patient and the results of therapy with preparations of levodopa and the method of biological feedback (BFB).В статье рассмотрен клинический случай аутосомно-доминантной доФа-зависимой торсионной дистонии, проведен анализ родословной, выделены особенности заболевания в семье. также описан неврологический статус пациента, результаты терапии препаратами леводопы и методом биологической обратной связи (БоС)

Sentinel lymph node biopsy for oral tongue squamous cell carcinoma cT1–2N0: prospective single-center study

The study objective is to evaluate the informativeness of the biopsy technique of the signal lymph node (LN) in squamous cell carcinoma of the tongue cT1–2N0.Materials and methods. A prospective, single-center study included 26 patients with morphologically verified squamous cell carcinoma of the tongue cT1–2 and the lack of clinical and radiological data for metastatic damage to the LNs of the neck. All patients underwent a radioisotope study of the lymphatic flow from the primary tumor and the topography of the signal LNs. The informativeness of the biopsy of the signal LNs was evaluated in accordance with 2 diagnostic models. When using the first diagnostic model, all LNs accumulating colloids labeled with the 99mTc isotope were considered signal LNs. In the second model, only nodes accumulating radiocolloids and located in the immediate vicinity of the primary tumor of the tongue and / or connected with the primary tumor by the “pathway” of the lymphatic vessels were considered as signal LNs. Results. The sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy, according to the 1st diagnostic model, were 66.6 % (95 % confidence interval (CI) 9.43–99.16), 100 % (95 % CI 85.18–100 %), 100 %, 95.83 % (95 % CI 82.28–99.13 %), 96.15 % (95 % CI 80.36–99.90 %), and when all LNs located along with the signal LNs were removed at the same levels as regional LNs, the sensitivity increased to 100 %. In the second model, the diagnostic values were: 33.3 % (95 % CI 0.84–90.57), 100 % (95 % CI 85.18– 100.00), 100 %, 92 % (95 % CI 83.78–96.24), 92.31 % (95 % CI 74.87–99.05 %). Conclusion. Evaluation of lymphatic outflow from the primary tumor and assessment of sentinel lymph node location in patients with stage cT1–2N0M0 squamous cell carcinoma of the tongue allow a doctor to determine the volume of lymph node dissection for each patient individually. Unilateral lymph node dissection is acceptable in patients with unilateral lymphatic outflow, whereas in patients with bilateral lymphatic outflow, it is associated with a quite high (up to 10 %) risk of metastatic lesions in the lymph nodes on the opposite side of the neck. It is necessary to excise all lymph nodes accumulating radiocontrast agent and regional lymph nodes located at the same levels

A lesion of contralateral neck lymph nodes in oral tongue cancer with clinically negative neck lymph nodes (clinical case)

The objective is to present a clinical case of combined treatment of cancer of the tongue and its progression to the contralateral lymph nodes of the neck using data on individual lymphatic outflow from the primary tumor of the tongue.Clinical case. Clinical, laboratory, radiological and pathomorphological data of a 50-year-old patient with a diagnosis of squamous human papillomavirus-negative cancer of the free part of the tongue and clinically negative lymph nodes of the neck with cT2N0M0. The patient underwent radical surgical treatment in the amount of hemiglossectomy and ipsilateral selective cervical lymphadenectomy after two courses of polychemotherapy according to the cisplatin + 5-fluorocracil regimen with partial regression and adjuvant treatment in the amount of conformal remote radiation therapy combined with chemotherapy. 9 months after the end of treatment, progression to the lymph nodes of the neck of the contralateral side was revealed, which accumulated a radiopharmaceutical before treatment.Conclusion. The described clinical case shows the importance of studying the lymphatic outflow from the primary tumor of the tongue to the regional lymph nodes in order to plan surgical treatment on the regional lymphatic collector in patients with squamous cell carcinoma of the free part of the tongue

Conformational and Coordination Equilibria on DOTA Complexes of Lanthanide Metal Ions in Aqueous Solution Studied by 1H-NMR Spectroscopy

A variable-temperature, -pressure, and -ionic strength 1H NMR study of the DOTA complexes of different trivalent cations (Sc, Y, La, Ce → Lu) (DOTA = 1,4,7,10-tetraaza-1,4,7,10-tetrakis(carboxymethyl)cyclododecane) yielded data that are in contradiction with the hitherto used model of only two enantiomeric pairs of diastereoisomers that differ in the ligand conformations. A two-isomer equilibrium cannot explain the newly observed apparent reversal of the isomer ratio at the end of the series. As both conformers may lose their inner sphere water molecule, a coordination equilibrium may be superimposed on this conformational equilibrium, as shown by large positive reaction volumes for the isomerization of [Ln(DOTA)(H2O)x]- (Ln = Yb, Lu; x = 1, 0). The isomerization of [Nd(DOTA)(H2O)]- and [Eu(DOTA)(H2O)]- is purely conformational, as shown by near-zero reaction volumes. The measured isomerization enthalpies and entropies agree with this model. The shift of the isomerization equilibria by a variety of non-coordinative salts depends on the ligand conformation rather than the presence or absence of the inner sphere water molecule. This results from weak ion binding and water solvent stabilization of one ligand conformation, rather than the decrease of the activity of the bulk water in the solution, as shown by UV−vis measurements of the coordination number sensitive transition 5F0 → 7D0 of Eu(III) as a function of ionic strength. Fluoride ions replace a water molecule in the inner coordination sphere, preferentially for one of the conformational isomers, as proven by 19F-NMR shifts and the appearance of a third set of resonances corresponding to [Eu(DOTA)F]2- in the 1H-NMR spectrum of [Eu(DOTA)(H2O)]-