FabSpace 2.0: A Platform for Application and Service Development based on Earth Observation Data

The goal of FabSpace 2.0 project is to transform Universities to Open Innovation Centers for their corresponding region and improve their societal contribution to the socioeconomic and environmental performance. For this purpose, the project provides to students, researchers, as well as to citizens or even companies, with a framework and a digital platform which gives open access to a range of geodata, i.e. Earth Observation data, but also computing and visualization tools. By this way, it is expected that the participants can work in an open co-working space, where they can interact with each other. Additionally, the participants will be assisted to assess the business aspects of any potential idea. The outcome of such an activity is the increase of possibility for participants to find a revolutionary concept, which can result to new and sustainable applications and/or services. Moreover the target group exceeds the usual Earth Observation professionals, and focuses also in professionals of other disciplines, where the use of Earth Observation data can create novel technologies

New criteria for selecting the origin of DNA replication in Wolbachia and closely related bacteria

© 2007 Ioannidis et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The definitive version was published in BMC Genomics 8 (2007): 182, doi:10.1186/1471-2164-8-182.Background: The annotated genomes of two closely related strains of the intracellular bacterium Wolbachia pipientis have been reported without the identifications of the putative origin of replication (ori). Identifying the ori of these bacteria and related alpha-Proteobacteria as well as their patterns of sequence evolution will aid studies of cell replication and cell density, as well as the potential genetic manipulation of these widespread intracellular bacteria. Results: Using features that have been previously experimentally verified in the alpha-Proteobacterium Caulobacter crescentus, the origin of DNA replication (ori) regions were identified in silico for Wolbachia strains and eleven other related bacteria belonging to Ehrlichia, Anaplasma, and Rickettsia genera. These features include DnaA-, CtrA- and IHF-binding sites as well as the flanking genes in C. crescentus. The Wolbachia ori boundary genes were found to be hemE and COG1253 protein (CBS domain protein). Comparisons of the putative ori region among related Wolbachia strains showed higher conservation of bases within binding sites. Conclusion: The sequences of the ori regions described here are only similar among closely related bacteria while fundamental characteristics like presence of DnaA and IHF binding sites as well as the boundary genes are more widely conserved. The relative paucity of CtrA binding sites in the ori regions, as well as the absence of key enzymes associated with DNA replication in the respective genomes, suggest that several of these obligate intracellular bacteria may have altered replication mechanisms. Based on these analyses, criteria are set forth for identifying the ori region in genome sequencing projects.PI, PS, SS, GT and KB acknowledge support of their work from intramural funding from the University of Ioannina. SB, JDH, LB and JW acknowledge support of their work from the U.S. National Science Foundation grant EF-0328363. SB also acknowledges the support from the NASA Astrobiology Institute (NNA04CC04A

Architecture-Level Exploration of Alternative Interconnection Schemes Targeting 3D FPGAs: A Software-Supported Methodology

In current reconfigurable architectures, the interconnection structures increasingly contribute more to the delay and power consumption. The demand for increased clock frequencies and logic density (smaller area footprint) makes the problem even more important. Three-dimensional (3D) architectures are able to alleviate this problem by accommodating a number of functional layers, each of which might be fabricated in different technology. However, the benefits of such integration technology have not been sufficiently explored yet. In this paper, we propose a software-supported methodology for exploring and evaluating alternative interconnection schemes for 3D FPGAs. In order to support the proposed methodology, three new CAD tools were developed (part of the 3D MEANDER Design Framework). During our exploration, we study the impact of vertical interconnection between functional layers in a number of design parameters. More specifically, the average gains in operation frequency, power consumption, and wirelength are 35%, 32%, and 13%, respectively, compared to existing 2D FPGAs with identical logic resources. Also, we achieve higher utilization ratio for the vertical interconnections compared to existing approaches by 8% for designing 3D FPGAs, leading to cheaper and more reliable devices

A novel framework for exploring 3-D FPGAs with heterogeneous interconnect fabric

A heterogeneous interconnect architecture can be a useful approach for the design of 3-D FPGAs. A methodology to investigate heterogeneous interconnection schemes for 3-D FPGAs under different 3-D fabrication technologies is proposed. Application of the proposed methodology on benchmark circuits demonstrates an improvement in delay, power consumption, and total wire-length of approximately 41%, 32%, and 36%, respectively, as compared to 2-D FPGAs. These improvements are additional to reducing the number of interlayer connections. The fewer interlayer connections are traded off for a higher yield. An area model to evaluate this trade-off is presented. Results indicate that a heterogeneous 3-D FPGA requires 37% less area as compared to a homogeneous 3-D FPGA. Consequently, the heterogeneous FPGAs can exhibit a higher manufacturing yield. A design toolset is also developed to support the design and exploration of various performance metrics for the proposed 3-D FPGAs