Eliashberg's proof of Cerf's theorem

Following a line of reasoning suggested by Eliashberg, we prove Cerf's theorem that any diffeomorphism of the 3-sphere extends over the 4-ball. To this end we develop a moduli-theoretic version of Eliashberg's filling-with-holomorphic-discs method.Comment: 32 page

Scalar field propagation in the phi^4 kappa-Minkowski model

In this article we use the noncommutative (NC) kappa-Minkowski phi^4 model based on the kappa-deformed star product, ({*}_h). The action is modified by expanding up to linear order in the kappa-deformation parameter a, producing an effective model on commutative spacetime. For the computation of the tadpole diagram contributions to the scalar field propagation/self-energy, we anticipate that statistics on the kappa-Minkowski is specifically kappa-deformed. Thus our prescription in fact represents hybrid approach between standard quantum field theory (QFT) and NCQFT on the kappa-deformed Minkowski spacetime, resulting in a kappa-effective model. The propagation is analyzed in the framework of the two-point Green's function for low, intermediate, and for the Planckian propagation energies, respectively. Semiclassical/hybrid behavior of the first order quantum correction do show up due to the kappa-deformed momentum conservation law. For low energies, the dependence of the tadpole contribution on the deformation parameter a drops out completely, while for Planckian energies, it tends to a fixed finite value. The mass term of the scalar field is shifted and these shifts are very different at different propagation energies. At the Planckian energies we obtain the direction dependent kappa-modified dispersion relations. Thus our kappa-effective model for the massive scalar field shows a birefringence effect.Comment: 23 pages, 2 figures; To be published in JHEP. Minor typos corrected. Shorter version of the paper arXiv:1107.236

Scalar field theory on κ\kappa-Minkowski space-time and Doubly Special Relativity

In this paper we recall the construction of scalar field action on $\kappa$-Minkowski space-time and investigate its properties. In particular we show how the co-product of $\kappa$-Poincar\'e algebra of symmetries arises from the analysis of the symmetries of the action, expressed in terms of Fourier transformed fields. We also derive the action on commuting space-time, equivalent to the original one. Adding the self-interaction $\Phi^4$ term we investigate the modified conservation laws. We show that the local interactions on $\kappa$-Minkowski space-time give rise to 6 inequivalent ways in which energy and momentum can be conserved at four-point vertex. We discuss the relevance of these results for Doubly Special Relativity.Comment: 17 pages; some editing done, final version to be published in Int. J. Mod. Phys.

κ\kappa-Deformation of Poincar\'e Superalgebra with Classical Lorentz Subalgebra and its Graded Bicrossproduct Structure

The $\kappa$-deformed $D=4$ Poincar{\'e} superalgebra written in Hopf superalgebra form is transformed to the basis with classical Lorentz subalgebra generators. We show that in such a basis the $\kappa$-deformed $D=4$ Poincare superalgebra can be written as graded bicrossproduct. We show that the $\kappa$-deformed $D=4$ superalgebra acts covariantly on $\kappa$-deformed chiral superspace.Comment: 13 pages, late

Two Coupled Harmonic Oscillators on Non-commutative Plane

We investigate a system of two coupled harmonic oscillators on the non-commutative plane \RR^2_{\theta} by requiring that the spatial coordinates do not commute. We show that the system can be diagonalized by a suitable transformation, i.e. a rotation with a mixing angle \alpha. The obtained eigenstates as well as the eigenvalues depend on the non-commutativity parameter \theta. Focusing on the ground state wave function before the transformation, we calculate the density matrix \rho_0(\theta) and find that its traces {\rm Tr}(\rho_{0}(\theta)) and {\rm Tr}(\rho_0^2(\theta)) are not affected by the non-commutativity. Evaluating the Wigner function on \RR^2_{\theta} confirms this. The uncertainty relation is explicitly determined and found to depend on \theta. For small values of \theta, the relation is shifted by a \theta^2 term, which can be interpreted as a quantum correction. The calculated entropy does not change with respect to the normal case. We consider the limits \alpha=1 and \alpha={\pi\over 2}. In first case, by identifying \theta to the squared magnetic length, one can recover basic features of the Hall system.Comment: 15 pages, 1 figur

Two-loop Renormalization for Nonanticommutative N=1/2 Supersymmetric WZ Model

We study systematically, through two loops, the divergence structure of the supersymmetric WZ model defined on the N=1/2 nonanticommutative superspace. By introducing a spurion field to represent the supersymmetry breaking term F^3 we are able to perform our calculations using conventional supergraph techniques. Divergent terms proportional to F, F^2 and F^3 are produced (the first two are to be expected on general grounds) but no higher-point divergences are found. By adding ab initio F and F^2 terms to the original lagrangian we render the model renormalizable. We determine the renormalization constants and beta functions through two loops, thus making it possible to study the renormalization group flow of the nonanticommutation parameter.Comment: 36 pages, 25 figures, Latex fil

Doubly Special Relativity and de Sitter space

In this paper we recall the construction of Doubly Special Relativity (DSR) as a theory with energy-momentum space being the four dimensional de Sitter space. Then the bases of the DSR theory can be understood as different coordinate systems on this space. We investigate the emerging geometrical picture of Doubly Special Relativity by presenting the basis independent features of DSR that include the non-commutative structure of space-time and the phase space algebra. Next we investigate the relation between our geometric formulation and the one based on quantum $\kappa$-deformations of the Poincar\'e algebra. Finally we re-derive the five-dimensional differential calculus using the geometric method, and use it to write down the deformed Klein-Gordon equation and to analyze its plane wave solutions.Comment: 26 pages, one formula (67) corrected; some remarks adde

Poincare covariant mechanics on noncommutative space

The Dirac approach to constrained systems can be adapted to construct relativistic invariant theories on a noncommutative (NC) space. As an example, we propose and discuss relativistic invariant NC particle coupled to electromagnetic field by means of the standard term $A^\mu\dot x_\mu$. Poincare invariance implies deformation of the free particle NC algebra in the interaction theory. The corresponding corrections survive in the nonrelativistic limit.Comment: 7 pages, JHEP style, final versio

A human colonic crypt culture system to study regulation of stem cell-driven tissue renewal and physiological function

The intestinal epithelium is one of the most rapidly renewing tissues in the human body and fulfils vital physiological roles such as barrier function and transport of nutrients and fluid. Investigation of gut epithelial physiology in health and disease has been hampered by the lack of ex vivo models of the native human intestinal epithelium. Recently, remarkable progress has been made in defining intestinal stem cells and in generating intestinal organoid cultures. In parallel, we have developed a 3D culture system of the native human colonic epithelium that recapitulates the topological hierarchy of stem cell-driven tissue renewal and permits the physiological study of native polarized epithelial cells. Here we describe methods to establish 3D cultures of intact human colonic crypts and conduct real-time imaging of intestinal tissue renewal, cellular signalling, and physiological function, in conjunction with manipulation of gene expression by lentiviral or adenoviral transduction. Visualization of mRNA- and protein-expression patterns in cultured human colonic crypts, and cross-validation with crypts derived from fixed mucosal biopsies, is also described. Alongside studies using intestinal organoids, the near-native human colonic crypt culture model will help to bridge the gap that exists between investigation of colon cancer cell lines and/or animal (tissue) studies, and progression to clinical trials. To this end, the near native human colonic crypt model provides a platform to aid the development of novel strategies for the prevention of inflammatory bowel disease and cancer

Longitudinal borehole functionality in 15 rural Ghanaian towns from three groundwater quality clusters

OBJECTIVE: In sub-Saharan Africa, 45% of the rural population uses boreholes (BHs). Despite recent gains in improved water access and coverage, parallel use of unimproved sources persists. Periodic infrastructure disrepair contributes to non-exclusive use of BHs. Our study describes functionality of BHs in 2014, 2015, and 2016 in 15 rural towns in the Eastern Region of Ghana sourced from three groundwater quality clusters (high iron, high salinity, and control). We also assess factors affecting cross-sectional and longitudinal functionality using logistic regression. RESULTS: BH functionality rates ranged between 81 and 87% and were similar across groundwater quality clusters. Of 51 BHs assessed in all three years, 34 (67%) were consistently functional and only 3 (6%) were consistently broken. There was a shift toward proactive payment for water over the course of the study in the control and high-salinity clusters. Payment mechanism, population served, presence of nearby alternative water sources, and groundwater quality cluster were not significant predictors of cross-sectional or longitudinal BH functionality. However, even in the high iron cluster, where water quality is poor and no structured payment mechanism for water exists, BHs are maintained, showing that they are important community resources