Opportunities and challenges of working with gifted and talented students in an urban context: A university-based intervention program

This is the author's accepted manuscript. The final published article appeared in Gifted Child Today, 34(1), 2011. Copyright 2011 @ Sage Publications.No abstract available

Reactive thrombocytosis and pseudohyperkalemia-entities we come across occasionally

AbstractThrombocytosis and hyperkalemia are entities which can have sinister complications in the perioperative period and can be worrisome to the alert anesthesiologist. Hence it is good to be aware of variants which are quite benign and need not lead to delaying of anaesthesia administration. One such case is reported to highlight this fact

Nurturing the young shoots of talent: Using action research for exploration and theory building

This is an Author's Accepted Manuscript of an article published in European Early Childhood Education Research Journal, 19(4), 433-450, 2011, copyright Taylor & Francis, available online at: http://www.tandfonline.com/10.1080/1350293X.2011.623515.This paper reports the outcomes of a set of action research projects carried out by teacher researchers in 14 local education authorities in England, working collaboratively with university tutors, over a period of three years. The common aim of all the projects was to explore practical ways of nurturing the gifts and talents of children aged four–seven years. The project was funded by the Department of Education and Skills in England as part of the government's gifted and talented programme. The project teachers felt that their understanding of issues relating to nurturing the gifts and talents of younger children was enhanced through their engagement in the project. It was possible to map the findings of the projects to the English government's National Quality Standards for gifted and talented education which include: (1) identification; (2) effective provision in the classroom; (3) enabling curriculum entitlement and choice; (4) assessment for learning; (5) engaging with community, families and beyond. The findings are also analysed within the framework of good practice in educating children in the first years of schooling. Participating practitioners felt that action research offered them a suitable methodology to explore the complexity of the topic of giftedness through cycles of planning, action and reflection and personal theory building

Mathematically gifted and talented learners: Theory and practice

This is an Author's Accepted Manuscript of an article published in International Journal of Mathematical Education in Science and Technology, 40(2), 213-228, 2009, copyright Taylor & Francis, available online at: http://www.tandfonline.com/10.1080/00207390802566907.There is growing recognition of the special needs of mathematically gifted learners. This article reviews policy developments and current research and theory on giftedness in mathematics. It includes a discussion of the nature of mathematical ability as well as the factors that make up giftedness in mathematics. The article is set in the context of current developments in Mathematics Education and Gifted Education in the UK and their implications for Science and Technology. It argues that early identification and appropriate provision for younger mathematically promising pupils capitalizes on an intellectual resource which could provide future mathematicans as well as specialists in Science or Technology. Drawing on a Vygotskian framework, it is suggested that the mathematically gifted require appropriate cognitive challenges as well as attitudinally and motivationally enhancing experiences. In the second half of this article we report on an initiative in which we worked with teachers to identify mathematically gifted pupils and to provide effective enrichment support for them, in a number of London Local Authorities. A number of significant issues are raised relating to the identification of mathematical talent, enrichment provision for students and teachers’ professional development

Recycling Waste Electrical Socket as a Carbon Resource in Ironmaking

Globally, millions of waste electrical sockets (WES) are generated annually. This category of waste material is difficult to recycle because they are thermosetting polymers which cannot be remoulded after setting. In this work, the reduction of medium grade Agbaja iron ore from Nigeria, by carbonaceous materials generated from WES was investigated through experiments conducted in a domestic microwave oven. Composite pellets of medium grade Agbaja iron ore (assaying ~74 % Fe2O3) with WES were irradiated in a domestic microwave oven (Pioneer, Model PM-25 L, 2450 MHz and 1000 W). The reduced mass was characterised by XRD and SEM/EDS analyses and the extent of reduction after 40 min was determined. SEM/EDS analysis revealed a highly reduced mass with distinct peaks of elemental iron and this was corroborated by XRD analyses that confirmed the formation of metallic iron. The extent of reduction obtained after using WES as reductant was over 80%. Accordingly, carbonaceous materials generated from waste electrical sockets are effective reductants for producing metallic iron from the Agbaja iron ore. Keywords: Waste Electrical Sockets, Thermosetting Polymer, Agbaja Iron Ore; Municipal Solid Waste

Comparison of homogeneous and heterogeneous motorised traffic at signalised and two-way stop control single lane intersection

Results of a microscopic model of mixed motorised traffic consisting of short vehicles, (e.g. cars), and long vehicles, (taken to be double the length of the short vehicles), for an urban two-way single lane intersection are presented here. We model the intersection using both signalised and un-signalised stop control rules. The model allows for the detection of bottleneck activity in both homogenous and heterogeneous traffic conditions, and was validated by means of field data collected in Dublin, Ireland. The validated model was used to study the impact of inclusion of long vehicles on traffic performance in an urban environment. Traffic mix is, however, taken to be dominated by short vehicles overall, in argument with observed live data collected

Production of Metallic Iron from the Pudo Magnetite Ore using End-of-Life Rubber Tyre as Reductant: The Role of an Underlying Ankerite Ore as a Fluxing Agent on Productivity

This research work investigated the nature of a nonmagnetic ore from Pudo in the Upper West Region of Ghana and its fluxing effect on the extent of reduction of the Pudo titaniferous magnetite ore using pulverised samples of charred carbonaceous materials generated from end-of-life vehicle tyres (ELT) as reductants. Reduction studies were conducted on composite pellets of the Pudo titaniferous magnetite iron ore containing fixed amounts of charred ELT and varying amounts (0%, 10%, 15%, 20%, 30%, 40% and 50%) of the nonmagnetic fluxing material in a domestic microwave oven and the extent of reduction was calculated after microwave irradiation for 40 minutes. Analyses by XRF, SEM/EDS and XRD of the nonmagnetic ore revealed an Ankerite type of ore of the form Ca0.95Fe0.95Mn0.1 (CO3)2. From the microwave reduction studies it was observed that premium grade metallic iron could be produced from appropriate blends of the Pudo iron ores using ELT as reductant, with a measured extent of reduction up to 103.8%. Further, the extent of reduction was observed to increase with an increase in the amount of the nonmagnetic fluxing material (Ankerite) that was added as fluxing agent.   Keywords: Ankerite, End-of-life Rubber Tyres, Fluxing Agent, Extent of Reductio

The N-terminus and alpha-5, alpha-6 helices of the pro-apoptotic protein Bax, modulate functional interactions with the anti-apoptotic protein Bcl-xL

<p>Abstract</p> <p>Background</p> <p>Bcl-2 family proteins are key regulators of mitochondrial integrity and comprise both pro- and anti-apoptotic proteins. Bax a pro-apoptotic member localizes as monomers in the cytosol of healthy cells and accumulates as oligomers in mitochondria of apoptotic cells. The Bcl-2 homology-3 (BH3) domain regulates interactions within the family, but regions other than BH3 are also critical for Bax function. Thus, the N-terminus has been variously implicated in targeting to mitochondria, interactions with BH3-only proteins as well as conformational changes linked to Bax activation. The transmembrane (TM) domains (α5-α6 helices in the core and α9 helix in the C-terminus) in Bax are implicated in localization to mitochondria and triggering cytotoxicity. Here we have investigated N-terminus modulation of TM function in the context of regulation by the anti-apoptotic protein Bcl-x_L.</p> <p>Results</p> <p>Deletion of 29 amino acids in the Bax N-terminus (Bax 30–192) caused constitutive accumulation at mitochondria and triggered high levels of cytotoxicity, not inhibited by Bcl-x_L. Removal of the TM domains (Bax 30–105) abrogated mitochondrial localization but resulted in Bcl-x_Lregulated activation of endogenous Bax and Bax-Bak dependent apoptosis. Inclusion of the α5-α6 helices/TMI domain (Bax 30–146) phenocopied Bax 30–192 as it restored mitochondrial localization, Bcl-x_Lindependent cytotoxicity and was not dependent on endogenous Bax-Bak. Inhibition of function and localization by Bcl-x_Lwas restored in Bax 1–146, which included the TM1 domain. Regardless of regulation by Bcl-x_L, all N-terminal deleted constructs immunoprecipitated Bcl-x_Land converged on caspase-9 dependent apoptosis consistent with mitochondrial involvement in the apoptotic cascade. Sub-optimal sequence alignments of Bax and Bcl-x_Lindicated a sequence similarity between the α5–α6 helices of Bax and Bcl-x_L. Alanine substitutions of three residues (T14A-S15A-S16A) in the N-terminus (Bax-Ala3) attenuated regulation by the serine-threonine kinase Akt/PKB but not by Bcl-x_Lindicative of distinct regulatory mechanisms.</p> <p>Conclusion</p> <p>Collectively, the analysis of Bax deletion constructs indicates that the N-terminus drives conformational changes facilitating inhibition of cytotoxicity by Bcl-x_L. We speculate that the TM1 helices may serve as 'structural antagonists' for BH3-Bcl-x_Linteractions, with this function being regulated by the N-terminus in the intact protein.</p

A new framework for integrated climate finance and inclusive responses to sustainable development in Malaysia

With Malaysia’s commitment to both mitigation and adaptation, the 21st Conference of Parties to the United Nations Framework Convention for Climate Change in Paris, 2015, will be both an opportunity to showcase best practices and a forum to promote international ownership of climate challenge before it becomes a catastrophe. Our experience with weather extremes is that the best time to intervene is at the risk level via prevention and preparedness, compared to any wait-and-see approach. As the Honourable Prime Minister of Malaysia, Dato’ Sri Mohd Najib Abdul Razak, elaborated during the recent 11th Malaysia Plan presentation to the parliament, ‘such an approach has to be seen as part of adopting green growth and increasing our commitment to long-term sustainability’. Malaysia is also aware that this requires policy support, technological interventions and financial commitment. It is for this reason the Malaysia’s pledge at the Copenhagen COP-15 was to reduce its carbon emission by 40% from 2005 levels by 2020, subject to technology transfer and financial support by developed countries. Having achieved a 33% reduction in the last five years, Malaysia is convinced that it can reach the 40% target following an inclusive partnership framework for action