A Variable-Size Local Domain Approach to Computer Model Validation in Design Optimization

A common approach to the validation of simulation models focuses on validation throughout the entire design space. A more recent methodology validates designs as they are generated during a simulation-based optimization process. The latter method relies on validating the simulation model in a sequence of local domains. To improve its computational efficiency, this paper proposes an iterative process, where the size and shape of local domains at the current step are determined from a parametric bootstrap methodology involving maximum likelihood estimators of unknown model parameters from the previous step. Validation is carried out in the local domain at each step. The iterative process continues until the local domain does not change from iteration to iteration during the optimization process ensuring that a converged design optimum has been obtained. The proposed methodology is illustrated using a thermal, one-dimensional, linear heat conduction problem in a solid slab with heat flux boundary conditionsUpprättat;2011;20110822 (andbra); Konferensartikel i tidskrift;Bibliografisk uppgift: Paper Presented At: SAE 2011 World Congress &amp; Exhibition ,2011-04-12 ,Detroit, Michigan, United States.</p

Structural features of Prussian Blue-related iron complex FeT of activity to peroxidate unsaturated fatty acids - supplementary figures

Aim: FeT is a complex of Fe3+, ferricyanide and tartrate, similar in structure to Prussian Blue. Its synthesis was planned to produce a potential antiproliferative drug. Methods: Dynamic light scattering was applied to study nanostructures formed by FeT complexes, while their biological activity was tested following changes in cell proliferation using cultured T24 human bladder cancer cells. Results: The antiproliferative activity of FeT derived from its ability to peroxidate unsaturated fatty acids, which can cause cell death through oxidative stress and/or ferroptosis. FeT molecules associate into drop-like nanostructures in water solutions, between 10-130 nm, which can bind albumin. Conclusion: Fatty acid peroxidation is significantly activated by light. The characteristics and reactivity of FeT represent a prospective application in medicine.</p