Dat de facturen vatbaar zijn voor bezwaar en beroep, wil niet zeggen dat daarmee de weg naar de kantonrechter is afgesloten. Het bestuursorgaan beschikt ten aanzien van de invordering ook over de bevoegdheden die een schuldeiser op grond van het privaatrecht heeft.

Rb. Noord-Holland (ktr.)223The Legitimacy and Effectiveness of Law & Governance in a World of Multilevel Jurisdiction

Titel 4.4 Awb geëvalueerd: wat minder ambitie voor meer resultaat

Trias Europea: de verhoudingen tussen de overheidsmachten in de EU en de lidstaten in een bewegend constitutioneel landscha

De bevoegdheid tot invordering van de dwangsom is verjaard. Niet is gebleken dat verweerder enige invorderingshandeling heeft verricht om de verjaring te stuiten.

Rb. Gelderland224The Legitimacy and Effectiveness of Law & Governance in a World of Multilevel Jurisdiction

Determination of food synthetic dyes in acid-dairy products by the method of solid-phase spectrophotometry

Solid-phase extraction was studied for food synthetic dyes Tartrazine E102, Yellow "Sunset" E110, Ponso 4R E124 and the Patented Blue E131 from yoghurts and biokefirs in a transparent polymethylmethacrylate matrix as a solid extractant. The effectiveness of the proposed approach is shown to identify and determine the content of 2 food-grade synthetic dyes by visual and spectrophotometric methods. The optimal conditions for the analysis correspond to pH <3, the duration of dye extraction into the polymer matrix is 20 min, the range of detected concentrations is 0.2-40.0 mg / kg with a detection limit of 0.05 mg/kg, and an excess of sweeteners and preservatives does not significantly affect the results of the analysis

De bestuursrechtelijke geldschuldenregeling. Titel 4.4 Awb geëvalueerd

Trias Europea: de verhoudingen tussen de overheidsmachten in de EU en de lidstaten in een bewegend constitutioneel landscha

Holistic corpus-based dialectology

This paper is concerned with sketching future directions for corpus-based dialectology. We advocate a holistic approach to the study of geographically conditioned linguistic variability, and we present a suitable methodology, 'corpusbased dialectometry', in exactly this spirit. Specifically, we argue that in order to live up to the potential of the corpus-based method, practitioners need to (i) abandon their exclusive focus on individual linguistic features in favor of the study of feature aggregates, (ii) draw on computationally advanced multivariate analysis techniques (such as multidimensional scaling, cluster analysis, and principal component analysis), and (iii) aid interpretation of empirical results by marshalling state-of-the-art data visualization techniques. To exemplify this line of analysis, we present a case study which explores joint frequency variability of 57 morphosyntax features in 34 dialects all over Great Britain

Tenosynovial giant cell tumors as accidental findings after episodes of distortion of the ankle: two case reports

<p>Abstract</p> <p>Introduction</p> <p>Tenosynovial giant cell tumors are benign tumors of uncertain pathogenesis. They occur in the joints, tendons and synovial bursas. Due to a high recurrence rate of up to 50%, some authors call a giant cell tumor a semimalignant tumor. To date, less than 10 cases of tenosynovial giant cell tumor of the ankle have been published in the international medical literature.</p> <p>Case presentation</p> <p>In this case report, we present two patients with localized tumors that were detected accidentally after the occurrence of ankle sprains with persisting pain in the joint. The tumors were resected by open marginal surgery and regular follow-up examinations were carried out.</p> <p>Conclusions</p> <p>We present an unusual occurrence of a tumor along with a possible follow-up strategy, which has not been previously discussed in the international literature.</p

Radiotherapy for recurrent medulloblastoma in children and adolescents: survival after re-irradiation and first-time irradiation

Background: Radiotherapy (RT) involving craniospinal irradiation (CSI) is important in the initial treatment of medulloblastoma. At recurrence, the re-irradiation options are limited and associated with severe side-effects. Methods: For pre-irradiated patients, patients with re-irradiation (RT2) were matched by sex, histology, time to recurrence, disease status and treatment at recurrence to patients without RT2. Results: A total of 42 pre-irradiated patients with RT2 were matched to 42 pre-irradiated controls without RT2. RT2 improved the median PFS [21.0 (CI: 15.7–28.7) vs. 12.0 (CI: 8.1–21.0) months] and OS [31.5 (CI: 27.6–64.8) vs. 20.0 (CI: 14.0–36.7) months]. Concerning long-term survival after ten years, RT2 only lead to small improvements in OS [8% (CI: 1.4–45.3) vs. 0%]. RT2 improved survival most without (re)-resection [PFS: 17.5 (CI: 9.7–41.5) vs. 8.0 (CI: 6.6–12.2)/OS: 31.5 (CI: 27.6–NA) vs. 13.3 (CI: 8.1–20.1) months]. In the RT-naïve patients, CSI at recurrence improved their median PFS [25.0 (CI: 16.8–60.6) vs. 6.6 (CI: 1.5–NA) months] and OS [40.2 (CI: 18.7–NA) vs. 12.4 (CI: 4.4–NA) months]. Conclusions: RT2 could improve the median survival in a matched cohort but offered little benefit regarding long-term survival. In RT-naïve patients, CSI greatly improved their median and long-term survival