352 research outputs found
Improved Collective Thomson Scattering measurements of fast ions at ASDEX Upgrade
Understanding the behaviour of the confined fast ions is important in both
current and future fusion experiments. These ions play a key role in heating
the plasma and will be crucial for achieving conditions for burning plasma in
next-step fusion devices. Microwave-based Collective Thomson Scattering (CTS)
is well suited for reactor conditions and offers such an opportunity by
providing measurements of the confined fast-ion distribution function resolved
in space, time and 1D velocity space. We currently operate a CTS system at
ASDEX Upgrade using a gyrotron which generates probing radiation at 105 GHz. A
new setup using two independent receiver systems has enabled improved
subtraction of the background signal, and hence the first accurate
characterization of fast-ion properties. Here we review this new dual-receiver
CTS setup and present results on fast-ion measurements based on the improved
background characterization. These results have been obtained both with and
without NBI heating, and with the measurement volume located close to the
centre of the plasma. The measurements agree quantitatively with predictions of
numerical simulations. Hence, CTS studies of fast-ion dynamics at ASDEX Upgrade
are now feasible. The new background subtraction technique could be important
for the design of CTS systems in other fusion experiments.Comment: 4 pages, 4 figures, to appear in Proc. of "Fusion Reactor
Diagnostics", eds. F. P. Orsitto et al., AIP Conf. Pro
EFDA Task TW6-TPDS-DIADEV deliverable 2: ITER Fast Ion Collective Scattering Development of diagnostic components and techniques
Benchmark and combined velocity-space tomography of fast-ion D-alpha spectroscopy and collective Thomson scattering measurements
Fast-ion dynamics at ITER-relevant densities in ASDEX Upgrade measured with collective Thomson scattering
Seasonal influenza split vaccines confer partial cross-protection against heterologous influenza virus in ferrets when combined with the CAF01 adjuvant
Influenza epidemics occur annually, and estimated 5–10% of the adult population and 20–30% of children will become ill from influenza infection. Seasonal vaccines primarily work through the induction of neutralizing antibodies against the principal surface antigen hemagglutinin (HA). This important role of HA-specific antibodies explains why previous pandemics have emerged when new HAs have appeared in circulating human viruses. It has long been recognized that influenza virus-specific CD4(+) T cells are important in protection from infection through direct effector mechanisms or by providing help to B cells and CD8(+) T cells. However, the seasonal influenza vaccine is poor at inducing CD4(+) T-cell responses and needs to be combined with an adjuvant facilitating this response. In this study, we applied the ferret model to investigate the cross-protective efficacy of a heterologous trivalent influenza split-virion (TIV) vaccine adjuvanted with the CAF01 adjuvant, with proven ability to induce CD4(+) T-cell and antibody responses in mice, ferrets, pigs, primates, and humans. Our results indicate that CAF01-adjuvanted vaccine induces HA inhibition (HAI)-independent protection after heterologous challenge, manifested as reduced viral load and fever. On the other hand, we observe increased inflammation in the airways and more neutrophil and mononuclear cell infiltration in these ferrets when compared with optimally protected animals, i.e., ferrets receiving the same vaccine but a homologous challenge. This suggest that HAI-independent immunity induced by TIV + CAF01 can reduce viral shedding and systemic disease symptoms, but does not reduce local inflammation in the nasal cavity
Progress on the Fast Ion Millimetre Wave CTS Diagnostics on TEXTOR and ASDEX Upgrade and status of the CTS design for ITER
On the purported "backbone fluorescence" in protein three-dimensional fluorescence spectra
In this study, several proteins (albumin, lysozyme, insulin) and model compounds (Trp, Tyr, homopolypeptides) were used to demonstrate the origin of the fluorescence observed upon their excitation at 220–230 nm. In the last 10 years we have observed a worrying increase in the number of articles claiming that this fluorescence originates from the protein backbone, contrary to the established knowledge that UV protein emission is due to aromatic amino acids only. Overall, our data clearly demonstrate that the observed emission upon excitation at 220–230 nm is due to the excitation of Tyr and/or Trp, with subsequent emission from the lowest excited state (i.e. the same as obtained with 280 nm excitation) in agreement with Kasha's rule. Therefore, this fluorescence peak does not provide any information on backbone conformation, but simply reports on the local environment around the aromatic side chains, just as any traditional protein emission spectrum. The many papers in reputable journals erroneously reporting this peak assignment, contradicting 5 decades of prior knowledge, have led to the creation of a new dogma, where many authors and reviewers now take the purported backbone fluorescence as an established fact. We hope the current paper helps counter this new situation and leads to a reassessment of those papers that make this erroneous claim
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