ПРЕВЕНТИВНА ДІЯЛЬНІСТЬ ЯК ФАКТОР ПОПЕРЕДЖЕННЯ ДЕВІАНТНОЇ ПОВЕДІНКИ ПІДЛІТКІВ

In clause is considered questions prévention of activity as factor of the prévention déviation of behaviour of the teenagers, and also basis ofpreventive maintenance déviation of behaviour

SUBSTANTIATION OF ECONOMIC EFFECTIVENESS OF INVESTMENT PROJECTS

Abstract. In article results of scientific research of a complex estimation of economic efficiency of investment projects are submitted. The basic theoretical positions and methodological principles which realization allows to generate a structural control system of investment process at the enterprise are established and to construct economic-mathematical model of his realization. Development of theoretical-methodological base of realization of a complex estimation of economic efficiency of investment projects is reached on the basis of realization of the put forward hypothesis about dependence of the investment decision not only on economic efficiency of investments, but also on aneconomic condition of the managing subject. In research substantive provisions of the theory of systems and also general scientific methods of the analysis and synthesis for the qualitative and quantitative description of a complex estimation of economic efficiency of investment projects are used. For realization of a complex estimation of economic efficiency of investment projects it is offered to establish dependence between economic efficiency of investments and an economic condition of the managing subject. The economic condition of the managing subject is recommended to describe parameters which joint consideration forms corresponding cluster or a hypercube of values in which positioning the enterprise and definition of his real and perspective position, and also construction of a trajectory ofstrategic development is carried out. The structural system generated on considered methodological principles has allowed to develop its basic elements and to construct economic-mathematical model of a complex estimation of economic efficiency of investment projects. The received results of scientific research in the field of a complex estimation of economic efficiency of investment projects essentially expand theoretical positions and methodological approaches of investment activity of the enterprise. Practical use of the received results of scientific research will allow making the effective investment deci-sions providing achievement by the managing subject of the required economic condition and realization of a trajectory chosen him of strategic development.Keywords: investment project, economic efficiency, methodological principles, model, hypercube, cluste

ХАРАКТЕРИСТИКА ДЕВІАНТНОЇ ПОВЕДІНКИ ПІДЛІТКІВ І ПРИЧИНИ ЇЇ ВИНИКНЕННЯ

The artikale includes the analysis of special literature concerning characteristics of deviation behaviour teenager andcause its beginning

МЕТОДИКА ОРГАНІЗАЦІЇ ІГРОВОЇ ДІЯЛЬНОСТІ В МОЛОДШОМУ, СЕРЕДНЬОМУ ТА СТАРШОМУ ВІЦІ

The article depicts the methods of organizations of playing activity at the English les sons in younger , average and senior school age

ПРОБЛЕМА АГРЕСИВНОЇ ПОВЕДІНКИ ПІДЛІТКІВ ЯК СКЛАДОВА ДЕВІАНТНОСТІ

In given clause is considered as aggressive, aggression become in the future the basic reason for display deviation of behaviour of the teenagers; as the cruelty and aggressive behaviour are caused with disputed situations in school collective

ДЕВІАНТНА ПОВЕДІНКА ТА ОСОБИСТІСТЬ ПІДЛІТКА

The article are considered influence of crisis of teenage age on formation of the person of the teenager and social factors promoting deviation to behaviour

ХАРАКТЕРИСТИКА ТА СУТНІСТЬ ДЕЛІКВЕНТНОЇ ПОВЕДІНКИ ПІДЛІТКІВ

In given clause are considered essence delinquens behaviour, one of kinds deviations behaviour of the teenagers, the features and motives delinquention displays of the person of the teenager are opened

Disruption of the maxi-K-caveolin-1 interaction alters current expression in human myometrial cells

<p>Abstract</p> <p>Background</p> <p>One determinant of the total K+ myometrial smooth muscle cell (MSMC) current is the large conductance, calcium- and voltage-activated potassium channel (maxi-K channel). This channel provides a repolarizing current in response to excitatory stimuli, most notably in response to increases in the levels of intracellular Ca2+, and blocking the channel by pharmacological means induces the depolarization of MSMCs and also enhances contraction strength. In MSMCs, maxi-K channels can reside in the caveolae, where they associate with the scaffolding protein caveolin-1 (cav-1). The aim of this study was to investigate the consequences of this interaction - more specifically, how disruption of the association between the maxi-K channel and cav-1 may influence the current expression and excitability of myometrial cells - with the aim of better understanding the mechanisms that underlie the regulation of normal and aberrant uterine function.</p> <p>Methods</p> <p>Myometrial biopsies were collected from women undergoing elective C-sections. From these samples, myometrial cells were isolated, cultured, infected with a virus containing either caveolin-1 (cav-1) siRNA or scrambled cav-1 siRNA, and finally subjected to patch-clamp analysis. Mutant caveolin-binding site maxi-K channel constructs were generated and transfected into mouse Ltk- fibroblasts. Channel activity, expression, association, and localization were examined by patch-clamping, Western blot, immunoprecipitation, and immunofluorescence, respectively.</p> <p>Results</p> <p>The caveolin-1 siRNA suppressed the total K+ current in human myometrial smooth muscle cells (hMSMC), as evident from comparison to the currents generated by both non-infected cells and cells infected with scrambled siRNA controls. The interaction between the maxi-K channel and caveolin depends on a region in the channel's C-terminal caveolin-binding site. Mutations of aromatic residues in this site (mutant F1012A, mutant Y1007A, F1012A and mutant Y1007A, F1012A, Y1015A) resulted in a decrease in K+ current compared to that produced by wild-type channels transfected into mouse Ltk- fibroblasts. However, mutation of all three aromatic amino acids (mutant Y1007A, F1012A, Y1015A) was necessary to disrupt the association between caveolin and the maxi-K channel, as visualized by immunofluorescence and immunoprecipitation.</p> <p>Conclusion</p> <p>Our results suggest that disruption of the caveolin-binding site interferes with the cav-1/maxi-K channel interaction, and that lack of the cav-1/maxi-K channel interaction in MSMCs attenuates the total K+ channel current of the cell.</p