2,394 research outputs found
Pharmaceutical Cocrystals
AbstractCocrystals are very interesting and useful product. In this paper the main information about cocrystals is presented. It is shown that cocrystals are solid substances, which consist of few components mixed together. There are a lot of ways of cocrystals production and application. It is shown that cocrystals can be applied in medicine and pharmaceutical industry for improving different properties such as dissolution rate, melting point, solubility, chemical stability etc. Another way of cocrystals application is drug pharmacological action modification
Disinfection of water in swimming pools by combined action of UV-light and ozone
Disinfection of water in swimming pools by combined action of UV-light and ozone / 258st American Chemical Society National Meeting and Exposition Β«Division of Environmental ChemistryΒ», august 25-29, 2019, San Diego, CA. ENVR 394.P.5
ΠΠ½Π°Π»ΠΈΠ· ΡΠ΅ΠΊΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΡΠ°Π·Π΄Π΅Π»Π΅Π½ΠΈΡ ΡΠΌΠ΅ΡΠΈ H2OβD2O Π½Π° Π»Π΅Π³ΠΊΡΡ ΠΈ ΡΡΠΆΠ΅Π»ΡΡ Π²ΠΎΠ΄Ρ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΌΠ°ΡΠ΅ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ
Objectives. To apply an analytical method for the calculation of a distillation column for the production of D2O at a two-column Kuhn installation operating under vacuum: to simulate the Kuhn installation in the Hysys software; and to compare experimental and calculated data.Methods. Analytical method for the calculation of distillation columns βfrom stage to stage,β from the lower theoretical separation stage (TSS) to the upper stage. This method is based on phase equilibrium at the TSS with known data of input flows and component concentrations in the column bottoms. Hysys was used as modeling software.Results. Comparison of the calculation results with Kuhnβs experimental data testified to the high calculation accuracy of the vaporβliquid phase equilibrium for the H2OβD2O mixture at the TSS. The convergence of the D2O material balance for the entire installation was 0.005%. The identification parameter was the number of the column feed plate. Simulation of the Kuhn installation in the Hysys software showed a qualitative agreement of D2O concentrations in material flows. The UNIQUAC (UNIversal QUAsiChemical) model was used to calculate activity coefficients. The found values of the number of theoretical separation stages (NTSS) in both columns, were 88 and 153 taking into account the reboiler and condenser. This is less than the experimental 295 and 400, respectively. The discrepancy can be explained by the increased phase equilibrium H2O constant in the UNIQUAC model. However, the convergence of the material balance in terms of D2O was high and amounted to 1.38Β·10β6 %. The absolute error of the found concentrations in material flows did not exceed 0.12 mol %.Conclusions. The results obtained indicated the possible use of the Hysys modeling software when searching for and optimizing the operating mode of the block diagram of a cascade of distillation columns with direct and recycle flows to separate a mixture of water into light and heavy water. The final results obtained with regard to the operating mode, inlet and outlet material flows (flow rate, composition, temperature, and pressure drop across the column) are recommended for use in the analytical program for the calculation of the distillation column to refine the NTSS and distribution profile of the concentrations of the H2O and D2O components along the height of the column.Π¦Π΅Π»ΠΈ. ΠΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π°Π½Π°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠ΅ΡΠΎΠ΄Π° ΡΠ°ΡΡΠ΅ΡΠ° ΡΠ΅ΠΊΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΠΊΠΎΠ»ΠΎΠ½Π½Ρ Π΄Π»Ρ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ D2O Π² Π΄Π²ΡΡ
ΠΊΠΎΠ»ΠΎΠ½Π½ΠΎΠΉ ΡΡΡΠ°Π½ΠΎΠ²ΠΊΠ΅ ΠΡΠ½Π°, ΡΠ°Π±ΠΎΡΠ°ΡΡΠ΅ΠΉ ΠΏΠΎΠ΄ Π²Π°ΠΊΡΡΠΌΠΎΠΌ. ΠΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΡΡΡΠ°Π½ΠΎΠ²ΠΊΠΈ ΠΡΠ½Π° Π² ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΠ½ΠΎΠΉ ΡΡΠ΅Π΄Π΅ Hysys. Π‘ΡΠ°Π²Π½Π΅Π½ΠΈΠ΅ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ
ΠΈ ΡΠ°ΡΡΠ΅ΡΠ½ΡΡ
Π΄Π°Π½Π½ΡΡ
.ΠΠ΅ΡΠΎΠ΄Ρ. ΠΠ½Π°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΌΠ΅ΡΠΎΠ΄ ΡΠ°ΡΡΠ΅ΡΠ° ΡΠ΅ΠΊΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΠΊΠΎΠ»ΠΎΠ½Π½Ρ Β«ΠΎΡ ΡΡΡΠΏΠ΅Π½ΠΈ ΠΊ ΡΡΡΠΏΠ΅Π½ΠΈΒ» ΠΎΡ Π½ΠΈΠΆΠ½Π΅ΠΉ ΡΠ΅ΠΎΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΡΠΏΠ΅Π½ΠΈ ΡΠ°Π·Π΄Π΅Π»Π΅Π½ΠΈΡ (Π’Π‘Π ) ΠΊ Π²Π΅ΡΡ
Π½Π΅ΠΉ, ΠΎΡΠ½ΠΎΠ²Π°Π½Π½ΡΠΉ Π½Π° ΡΠ°Π·ΠΎΠ²ΠΎΠΌ ΡΠ°Π²Π½ΠΎΠ²Π΅ΡΠΈΠΈ Π½Π° Π’Π‘Π ΠΏΡΠΈ ΠΈΠ·Π²Π΅ΡΡΠ½ΡΡ
ΠΈΡΡ
ΠΎΠ΄Π½ΡΡ
Π΄Π°Π½Π½ΡΡ
Π²Ρ
ΠΎΠ΄Π½ΡΡ
ΠΏΠΎΡΠΎΠΊΠΎΠ² ΠΈ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΉ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠ² Π² ΠΊΡΠ±Π΅ ΠΊΠΎΠ»ΠΎΠ½Π½Ρ. Π‘ΡΠ΅Π΄Π° ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Hysys.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π‘ΡΠ°Π²Π½Π΅Π½ΠΈΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΡΠ°ΡΡΠ΅ΡΠ° Ρ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠΌΠΈ Π΄Π°Π½Π½ΡΠΌΠΈ ΠΡΠ½Π° ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΠΎΠ²Π°Π»ΠΎ ΠΎ Π²ΡΡΠΎΠΊΠΎΠΉ ΡΠΎΡΠ½ΠΎΡΡΠΈ ΡΠ°ΡΡΠ΅ΡΠ° ΡΠ°Π²Π½ΠΎΠ²Π΅ΡΠΈΡ ΡΠ°Π· ΠΏΠ°Ρ β ΠΆΠΈΠ΄ΠΊΠΎΡΡΡ Π΄Π»Ρ ΡΠΌΠ΅ΡΠΈ H2OβD2O Π½Π° Π’Π‘Π . Π‘Ρ
ΠΎΠ΄ΠΈΠΌΠΎΡΡΡ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π±Π°Π»Π°Π½ΡΠ° ΠΏΠΎ D2O ΠΏΠΎ ΡΡΡΠ°Π½ΠΎΠ²ΠΊΠ΅ Π² ΡΠ΅Π»ΠΎΠΌ ΡΠΎΡΡΠ°Π²ΠΈΠ»Π° 0.005%. ΠΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠΌ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΡΠ²Π»ΡΠ»ΡΡ Π½ΠΎΠΌΠ΅Ρ ΡΠ°ΡΠ΅Π»ΠΊΠΈ ΠΏΠΈΡΠ°Π½ΠΈΡ ΠΊΠΎΠ»ΠΎΠ½Π½Ρ. ΠΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΡΡΡΠ°Π½ΠΎΠ²ΠΊΠΈ ΠΡΠ½Π° Π² ΡΡΠ΅Π΄Π΅ Hysys ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΎ ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠ΅ ΡΠΎΠ³Π»Π°ΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΉ D2O Π² ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΡΡ
ΠΏΠΎΡΠΎΠΊΠ°Ρ
. ΠΠ»Ρ ΡΠ°ΡΡΠ΅ΡΠ° ΠΊΠΎΡΡΡΠΈΡΠΈΠ΅Π½ΡΠΎΠ² Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Π° ΠΌΠΎΠ΄Π΅Π»Ρ UNIversal QUAsiChemical (UNIQUAC). ΠΠ°ΠΉΠ΄Π΅Π½Π½ΡΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΡ ΡΠΈΡΠ»Π° ΡΠ΅ΠΎΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΡΠΏΠ΅Π½Π΅ΠΉ ΡΠ°Π·Π΄Π΅Π»Π΅Π½ΠΈΡ (Π§Π’Π‘Π ) Π² ΠΎΠ±Π΅ΠΈΡ
ΠΊΠΎΠ»ΠΎΠ½Π½Π°Ρ
Ρ ΡΡΠ΅ΡΠΎΠΌ ΡΠ΅Π±ΠΎΠΉΠ»Π΅ΡΠ° ΠΈ ΠΊΠΎΠ½Π΄Π΅Π½ΡΠ°ΡΠΎΡΠ° ΡΠΎΡΡΠ°Π²Π»ΡΡΡ 88 ΠΈ 153, ΡΡΠΎ ΠΌΠ΅Π½ΡΡΠ΅ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ
295 ΠΈ 400 ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ. Π Π°ΡΡ
ΠΎΠΆΠ΄Π΅Π½ΠΈΠ΅ ΠΎΠ±ΡΡΡΠ½ΡΠ΅ΡΡΡ ΠΏΠΎΠ²ΡΡΠ΅Π½Π½ΡΠΌ Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΊΠΎΠ½ΡΡΠ°Π½ΡΡ ΡΠ°Π·ΠΎΠ²ΠΎΠ³ΠΎ ΡΠ°Π²Π½ΠΎΠ²Π΅ΡΠΈΡ H2O ΠΌΠΎΠ΄Π΅Π»ΠΈ UNIQUAC, ΠΎΠ΄Π½Π°ΠΊΠΎ ΡΡ
ΠΎΠ΄ΠΈΠΌΠΎΡΡΡ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π±Π°Π»Π°Π½ΡΠ° ΠΏΠΎ D2O Π²ΡΡΠΎΠΊΠ°Ρ ΠΈ ΡΠΎΡΡΠ°Π²Π»ΡΠ΅Ρ 1.38Β·10β6 %. ΠΠ±ΡΠΎΠ»ΡΡΠ½Π°Ρ ΠΏΠΎΠ³ΡΠ΅ΡΠ½ΠΎΡΡΡ Π½Π°ΠΉΠ΄Π΅Π½Π½ΡΡ
Π·Π½Π°ΡΠ΅Π½ΠΈΠΉ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΉ Π² ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΡΡ
ΠΏΠΎΡΠΎΠΊΠ°Ρ
Π½Π΅ ΠΏΡΠ΅Π²ΡΡΠ°Π΅Ρ 0.12 ΠΌΠΎΠ». %.ΠΡΠ²ΠΎΠ΄Ρ. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΡΡ ΠΎ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΠΌ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠΈ ΡΡΠ΅Π΄Ρ ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Hysys Π΄Π»Ρ ΠΏΠΎΠΈΡΠΊΠ° ΠΈ ΠΎΠΏΡΠΈΠΌΠΈΠ·Π°ΡΠΈΠΈ ΡΠ΅ΠΆΠΈΠΌΠ° ΡΠ°Π±ΠΎΡΡ ΡΡΡΡΠΊΡΡΡΠ½ΠΎΠΉ ΡΡ
Π΅ΠΌΡ ΠΊΠ°ΡΠΊΠ°Π΄Π° ΡΠ΅ΠΊΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΠΊΠΎΠ»ΠΎΠ½Π½ Ρ ΠΏΡΡΠΌΡΠΌΠΈ ΠΈ ΡΠ΅ΡΠΈΠΊΠ»ΠΎΠ²ΡΠΌΠΈ ΠΏΠΎΡΠΎΠΊΠ°ΠΌΠΈ Π΄Π»Ρ ΡΠ°Π·Π΄Π΅Π»Π΅Π½ΠΈΡ ΡΠΌΠ΅ΡΠΈ Π²ΠΎΠ΄Ρ Π½Π° Π»Π΅Π³ΠΊΡΡ ΠΈ ΡΡΠΆΠ΅Π»ΡΡ Π²ΠΎΠ΄Ρ. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ ΠΊΠΎΠ½Π΅ΡΠ½ΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΏΠΎ ΡΠ΅ΠΆΠΈΠΌΡ ΡΠ°Π±ΠΎΡΡ, Π²Ρ
ΠΎΠ΄Π½ΡΠΌ ΠΈ Π²ΡΡ
ΠΎΠ΄Π½ΡΠΌ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΡΠΌ ΠΏΠΎΡΠΎΠΊΠ°ΠΌ (ΡΠ°ΡΡ
ΠΎΠ΄, ΡΠΎΡΡΠ°Π², ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΠ°, ΠΏΠ΅ΡΠ΅ΠΏΠ°Π΄ Π΄Π°Π²Π»Π΅Π½ΠΈΠΉ ΠΏΠΎ ΠΊΠΎΠ»ΠΎΠ½Π½Π΅) ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄ΠΎΠ²Π°Π½ΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°ΡΡ Π² Π°Π½Π°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΠ΅ ΡΠ°ΡΡΠ΅ΡΠ° ΡΠ΅ΠΊΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΠΊΠΎΠ»ΠΎΠ½Π½Ρ Π΄Π»Ρ ΡΡΠΎΡΠ½Π΅Π½ΠΈΡ Π§Π’Π‘Π ΠΈ ΠΏΡΠΎΡΠΈΠ»Ρ ΡΠ°ΡΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΉ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠ² H2O ΠΈ D2O ΠΏΠΎ Π²ΡΡΠΎΡΠ΅ ΠΊΠΎΠ»ΠΎΠ½Π½Ρ
Hybrid tracking detector based on semiconductor and gas technologies
New Silicon-Gas Pixel Detector (SiGPD) is the result of the further development already proposed Gas-Pixel Detector (GPD). The only disadvantage of GPD was the uncertainty of the particle arriving time. The problem can be solved by additional silicon pixels implementation inside existed electronic chip epitaxial layer during regular chip production. The cost of new Si-Gas Pixel Detector remains practically the same. The new detectors have self-triggering properties and can be used for a first level trigger generation in the particle physics experiments and for many other applications
Stimulating of entrepreneursβ innovative activity in the Republic of Bashkortostan
The article views some aspects of promoting innovative activity in the Republic of Bashkortostan. The measures stimulating innovative activity have been grouped into blocks.1. Creating favorable conditions for innovative activity. 2. Increasing the populationβs innovative activity. 3. Development of the system of scientific and production cooperation and innovation commercialization. 4. Investment support of innovative projects. 5. Development of innovative infrastructure. 6. Development of innovative small businesses. 7. Information provision of innovative activity. The main directions of implementing the above-mentioned conditions are: - lawmaking activity in the Republic, taking into consideration the federal legislation, international standards and traditions; - financial and tax inducement of scientific-technical and innovative activity; - international technological integration; - private-state partnership in the sphere of innovative activity. Recommendations are suggested, relating to the innovative policy activation for more efficient fulfillment of the key functions of the Republicβs scientific and research sector. The authors conclude that the Republic has all necessary preconditions for small entrepreneurship functioning: the natural conditions favorable for many kinds of economic activity, the forming local market infrastructure for small business servicing, and the availability of large enterprises and centers of economic activity.Keywords: entrepreneur, entrepreneurship, innovation, innovative activity, region, infrastructure, investments, stimulation, monitoring
ΠΠΠ ΠΠΠΠΠΠΠΠ Π₯ΠΠΠΠΠ Π ΠΠΠΠΠΠΠΠΠΠΠ¬ΠΠ«Π₯ ΠΠΠΠΠ’ΠΠΠ₯ ΠΠΠ’ΠΠΠΠ Π€ΠΠ£ΠΠ ΠΠΠΠ’Π ΠΠ
The fluorimetric method of analysis has been proposed for the qualitative and quantitative determination of the food flavoring additive quinine in the tonic water. The fluorimetric method of analysis has high sensitivity, selectivity and express speed compared to the other methods. The optimal conditions for the quinine fluorimetric determination in the soft drinks were found: solvent - 0.01 M sulfuric acid, excitation wavelength of 353 nm, luminescence wavelength of 452 nm, strobe parameters - signal delay of 0.85 ΞΌs, signal duration of 21.25 ΞΌs. To increase the sensitivity of the developed method, quinine luminescence was studied in the various concentrations of sulfuric acid from 0.005 to 1.000 M, and the quantum yield of quinine luminescence in all the investigated concentrations of sulfuric acid was calculated. It has been established that the highest quinine luminescence intensity, the highest quantum yield, and the lowest solvent background signal were observed in 0.01 M H2SO4. The influence of the related compounds of the food matrix on the fluorimetric determination of quinine was studied. It has been established that the content of such components as sugar and citric acid in the soft drinks does not affect the luminescent signal of quinine. The detection limit of quinine was calculated, which amounted to 0.0019 mg/dm3. In order to verify the correctness of the fluorimetric method, the results were compared with the spectrophotometric method (maximum absorption of quinine at 347 nm). The results obtained by the two methods were in good agreement, and the detection limit of the fluorimetric method was higher compared to the known works. The proposed technique could be used to control the quality and safety of the soft drinks.Β Keywords: quinine, fluorimetry, tonic water, luminescence quantum yield, strobe parameters.DOI: http://dx.doi.org/10.15826/analitika.2019.23.3.007(Russian)A.Π. Nikolaeva, A.A. Ivanov, E.I. KorotkovaΒ National Research Tomsk Polytechnic University,Lenina prosp., 30 Tomsk, 634050, Russian FederationΠ€Π»ΡΠΎΡΠΈΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΌΠ΅ΡΠΎΠ΄ ΠΏΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½ Π΄Π»Ρ ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ ΠΈ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΠΏΠΈΡΠ΅Π²ΠΎΠΉ Π²ΠΊΡΡΠΎΠ°ΡΠΎΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π΄ΠΎΠ±Π°Π²ΠΊΠΈ Ρ
ΠΈΠ½ΠΈΠ½Π° Π² Π½Π°ΠΏΠΈΡΠΊΠ°Ρ
-ΡΠΎΠ½ΠΈΠΊΠ°Ρ
. ΠΡΠ±ΠΎΡ Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΠΌΠ΅ΡΠΎΠ΄Π° ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½ Π΅Π³ΠΎ Π²ΡΡΠΎΠΊΠΎΠΉ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡΡ, ΡΠ΅Π»Π΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ ΠΈ ΡΠΊΡΠΏΡΠ΅ΡΡΠ½ΠΎΡΡΡΡ ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ Π΄ΡΡΠ³ΠΈΠΌΠΈ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ. ΠΠ°ΠΉΠ΄Π΅Π½Ρ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΡΠ΅ ΡΡΠ»ΠΎΠ²ΠΈΡ ΡΠ»ΡΠΎΡΠΈΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ Ρ
ΠΈΠ½ΠΈΠ½Π° Π² Π½Π°ΠΏΠΈΡΠΊΠ°Ρ
: ΡΠ°ΡΡΠ²ΠΎΡΠΈΡΠ΅Π»Ρ β 0.01 Π ΡΠ΅ΡΠ½Π°Ρ ΠΊΠΈΡΠ»ΠΎΡΠ°, Π΄Π»ΠΈΠ½Π° Π²ΠΎΠ»Π½Ρ Π²ΠΎΠ·Π±ΡΠΆΠ΄Π΅Π½ΠΈΡ 353 Π½ΠΌ, Π΄Π»ΠΈΠ½Π° Π²ΠΎΠ»Π½Ρ Π»ΡΠΌΠΈΠ½Π΅ΡΡΠ΅Π½ΡΠΈΠΈ 452 Π½ΠΌ, ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΡ ΡΡΡΠΎΠ±Π° β Π·Π°Π΄Π΅ΡΠΆΠΊΠ° ΡΠΈΠ³Π½Π°Π»Π° 0.85 ΠΌΠΊΡ, Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡ ΡΠΈΠ³Π½Π°Π»Π° 21.25 ΠΌΠΊΡ. ΠΠ»Ρ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΡ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΡΠ°Π·ΡΠ°Π±Π°ΡΡΠ²Π°Π΅ΠΌΠΎΠΉ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π»ΡΠΌΠΈΠ½Π΅ΡΡΠ΅Π½ΡΠΈΠΈ Ρ
ΠΈΠ½ΠΈΠ½Π° ΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Ρ ΠΊΠ²Π°Π½ΡΠΎΠ²ΡΠ΅ Π²ΡΡ
ΠΎΠ΄Ρ Π»ΡΠΌΠΈΠ½Π΅ΡΡΠ΅Π½ΡΠΈΠΈ Ρ
ΠΈΠ½ΠΈΠ½Π° Π² ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΡΡ
ΡΠ΅ΡΠ½ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΡ ΠΎΡ 0.005 Π΄ΠΎ 1.000 Π. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ Π½Π°ΠΈΠ±ΠΎΠ»ΡΡΠ°Ρ ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΡΡΡ Π»ΡΠΌΠΈΠ½Π΅ΡΡΠ΅Π½ΡΠΈΠΈ Ρ
ΠΈΠ½ΠΈΠ½Π°, Π½Π°ΠΈΠ±ΠΎΠ»ΡΡΠΈΠΉ ΠΊΠ²Π°Π½ΡΠΎΠ²ΡΠΉ Π²ΡΡ
ΠΎΠ΄ ΠΈ Π½Π°ΠΈΠΌΠ΅Π½ΡΡΠΈΠΉ ΡΠΈΠ³Π½Π°Π» ΡΠΎΠ½Π° ΡΠ°ΡΡΠ²ΠΎΡΠΈΡΠ΅Π»Ρ Π½Π°Π±Π»ΡΠ΄Π°Π΅ΡΡΡ Π² 0.01 Π H2SO4. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΠΌΠ΅ΡΠ°ΡΡΠΈΡ
ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠ² ΠΏΠΈΡΠ΅Π²ΠΎΠΉ ΠΌΠ°ΡΡΠΈΡΡ Π½Π° ΡΠ»ΡΠΎΡΠΈΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ Ρ
ΠΈΠ½ΠΈΠ½Π°. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΡΠ°Ρ
Π°Ρ ΠΈ Π»ΠΈΠΌΠΎΠ½Π½Π°Ρ ΠΊΠΈΡΠ»ΠΎΡΠ° Π½Π΅ Π²Π»ΠΈΡΡΡ Π½Π° Π»ΡΠΌΠΈΠ½Π΅ΡΡΠ΅Π½ΡΠ½ΡΠΉ ΡΠΈΠ³Π½Π°Π» Ρ
ΠΈΠ½ΠΈΠ½Π°. Π Π°ΡΡΡΠΈΡΠ°Π½ ΠΏΡΠ΅Π΄Π΅Π» ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΈΡ Ρ
ΠΈΠ½ΠΈΠ½Π°, ΠΊΠΎΡΠΎΡΡΠΉ ΡΠΎΡΡΠ°Π²ΠΈΠ» 0.0019 ΠΌΠ³/Π΄ΠΌ3. ΠΠ»Ρ ΠΏΡΠΎΠ²Π΅ΡΠΊΠΈ ΠΏΡΠ°Π²ΠΈΠ»ΡΠ½ΠΎΡΡΠΈ ΡΠ»ΡΠΎΡΠΈΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΡΠΎ ΡΠΏΠ΅ΠΊΡΡΠΎΡΠΎΡΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠΎΠΉ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ Ρ
ΠΈΠ½ΠΈΠ½Π° Π² Π½Π°ΠΏΠΈΡΠΊΠ°Ρ
(ΠΌΠ°ΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΠΎΠ΅ ΠΏΠΎΠ³Π»ΠΎΡΠ΅Π½ΠΈΠ΅ Ρ
ΠΈΠ½ΠΈΠ½Π° ΠΏΡΠΈ 347 Π½ΠΌ).Β Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ, ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ Π΄Π²ΡΠΌΡ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠ°ΠΌΠΈ, Ρ
ΠΎΡΠΎΡΠΎ ΡΠΎΠ³Π»Π°ΡΡΡΡΡΡ, ΠΏΡΠΈ ΡΡΠΎΠΌ ΠΏΡΠ΅Π΄Π΅Π» ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΈΡ ΡΠ»ΡΠΎΡΠΈΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠ΅ΡΠΎΠ΄Π° Π½ΠΈΠΆΠ΅ ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ ΠΈΠ·Π²Π΅ΡΡΠ½ΡΠΌΠΈ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ. ΠΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Π½Π°Ρ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠ° ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Π° Π΄Π»Ρ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ ΠΊΠ°ΡΠ΅ΡΡΠ²Π° ΠΈ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΠΈ Π±Π΅Π·Π°Π»ΠΊΠΎΠ³ΠΎΠ»ΡΠ½ΡΡ
Π½Π°ΠΏΠΈΡΠΊΠΎΠ².ΠΠ»ΡΡΠ΅Π²ΡΠ΅ ΡΠ»ΠΎΠ²Π°: Ρ
ΠΈΠ½ΠΈΠ½, ΡΠ»ΡΠΎΡΠΈΠΌΠ΅ΡΡΠΈΡ, Π½Π°ΠΏΠΈΡΠΊΠΈ-ΡΠΎΠ½ΠΈΠΊΠΈ, ΠΊΠ²Π°Π½ΡΠΎΠ²ΡΠΉ Π²ΡΡ
ΠΎΠ΄ Π»ΡΠΌΠΈΠ½Π΅ΡΡΠ΅Π½ΡΠΈΠΈ, ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΡ ΡΡΡΠΎΠ±Π°DOI: http://dx.doi.org/10.15826/analitika.2019.23.3.00
Π€ΠΠΠΠΠ-Π₯ΠΠΠΠ§ΠΠ‘ΠΠΠ ΠΠΠΠΠΠΠΠΠ ΠΠΠ‘Π’Π ΠΠ ΠΠ¦ΠΠ‘Π‘Π ΠΠΠΠΠ’Π ΠΠΠΠ‘Π‘Π’ΠΠΠΠΠΠΠΠΠ― ΠΠΠ‘ΠΠΠ ΠΠΠ Π ΠΠ ΠΠ‘Π£Π’Π‘Π’ΠΠΠ ΠΠ ΠΠ ΠΠΠΠ«Π₯ ΠΠΠ’ΠΠΠΠ‘ΠΠΠΠΠ’ΠΠ
The effect of individual antioxidants on physico-chemical parameters of ORR was studied under conditions of liner semi-infinite diffusion. Rate constants for coupled homogeneous reduction of active oxygen by the range to flavonoids were calculated under the optimal linear sweep rate.Possibility of determination of the parameters of reduction of active oxygen process (chemical and electrochemical rate constant, reversibility of process) in addition of individual antioxidants was showed by the computer simulation. Identification of substances with antioxidant properties was illustrated by changing of reduction current of active oxygen.Keywords: oxygen reduction reaction, ORR, antioxidant, flavonoids, rate constant, voltammetry(Russian)DOI:Β http://dx.doi.org/10.15826/analitika.2013.17.4.007A.N. Vtorushina, E.I. Korotkova, S.G. Kataev*Β Tomsk Polytechnic University, Tomsk, Russian Federation*Tomsk State Pedagogical University, Tomsk, Russian FederationΠ Π°ΡΡΠΌΠΎΡΡΠ΅Π½Ρ ΡΠΈΠ·ΠΈΠΊΠΎ-Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π·Π°ΠΊΠΎΠ½ΠΎΠΌΠ΅ΡΠ½ΠΎΡΡΠΈ ΠΏΡΠΎΡΠ΅ΡΡΠ° ΡΠ»Π΅ΠΊΡΡΠΎΠ²ΠΎΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΡ ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄Π° (ΠΠΒ Π2) Π² ΠΏΡΠΈΡΡΡΡΡΠ²ΠΈΠΈ ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡΠ°Π»ΡΠ½ΡΡ
Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠΎΠ² Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
Π»ΠΈΠ½Π΅ΠΉΠ½ΠΎΠΉ ΠΏΠΎΠ»ΡΠ±Π΅ΡΠΊΠΎΠ½Π΅ΡΠ½ΠΎΠΉ Π΄ΠΈΡΡΡΠ·ΠΈΠΈ, ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Ρ ΠΊΠΎΠ½ΡΡΠ°Π½ΡΡ ΡΠΊΠΎΡΠΎΡΡΠΈ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠΎΠ² Ρ Π°ΠΊΡΠΈΠ²Π½ΡΠΌΠΈ ΡΠΎΡΠΌΠ°ΠΌΠΈ ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄Π° ΠΈ Π½Π΅ΠΊΠΎΡΠΎΡΡΠ΅ Π΄ΡΡΠ³ΠΈΠ΅ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΡ ΠΏΡΠΎΡΠ΅ΡΡΠ° Π΄Π»Ρ ΡΡΠ΄Π° ΡΠ»Π°Π²ΠΎΠ½ΠΎΠΈΠ΄ΠΎΠ² ΠΏΡΠΈ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΠΎΠΉ ΡΠΊΠΎΡΠΎΡΡΠΈ ΡΠ°Π·Π²Π΅ΡΡΠΊΠΈ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»Π°. ΠΠΎΠΊΠ°Π·Π°Π½Π° Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ Π½Π΅ΠΊΠΎΡΠΎΡΡΡ
ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ² ΠΏΡΠΎΡΠ΅ΡΡΠ° ΠΠΒ Π2 (ΠΊΠΎΠ½ΡΡΠ°Π½Ρ ΡΠΊΠΎΡΠΎΡΡΠΈ Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΈ ΡΠ»Π΅ΠΊΡΡΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅Π°ΠΊΡΠΈΠΈ, ΠΎΠ±ΡΠ°ΡΠΈΠΌΠΎΡΡΠΈ ΠΏΡΠΎΡΠ΅ΡΡΠ°) Π² ΠΏΡΠΈΡΡΡΡΡΠ²ΠΈΠΈ ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡΠ°Π»ΡΠ½ΡΡ
Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠΎΠ² Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΊΠΎΠΌΠΏΡΡΡΠ΅ΡΠ½ΠΎΠ³ΠΎ ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ, Π° ΡΠ°ΠΊΠΆΠ΅ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ Π²Π΅ΡΠ΅ΡΡΠ², ΠΎΠ±Π»Π°Π΄Π°ΡΡΠΈΡ
Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠ½ΡΠΌΠΈ ΡΠ²ΠΎΠΉΡΡΠ²Π°ΠΌΠΈ, ΠΏΠΎ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΠΎΠΊΠ° ΠΠΒ Π2 Π² ΠΏΡΠΈΡΡΡΡΡΠ²ΠΈΠΈ ΠΈΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΡΡ
ΠΎΠ±ΡΠ°Π·ΡΠΎΠ².ΠΠ»ΡΡΠ΅Π²ΡΠ΅ ΡΠ»ΠΎΠ²Π°: ΡΠ»Π΅ΠΊΡΡΠΎΠ²ΠΎΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΠ΅ ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄Π°, Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΡ, Π²ΠΎΠ»ΡΡΠ°ΠΌΠΏΠ΅ΡΠΎΠΌΠ΅ΡΡΠΈΡDOI:Β http://dx.doi.org/10.15826/analitika.2013.17.4.00
Modern Aspects of the Surgical Treatment of Children with Idiopathic Thrombocytopenic Purpura
The main link in the pathogenesis of ITP is an excessive elimination of platelets in venous sinuses of the spleen. It justifies the splenectomy in this pathology, which increases the immunosuppression, which is caused by earlier courses prednizolonotherapy. A violation of proteinsynthetical detoxifying and liver function plays an essential link in the pathogenesis of postsplenectomic syndrome. It exacerbates immunosuppression. The composition allows saving all the structural elements of viable lymphoid tissue in the spleen for 7 days. Delayed autotransplantation of preserved splenic tissue gives the body a full lymphoid tissue without signs of hyperplasia. Two-moment autotransplantation of preserved splenic tissue in ITP allows to cut short the phenomenon postsplenectomic immunosuppression with normalization of platelet counts in peripheral blood and to avoid disability. The developed medical complex, including splenectomy with followed by a delayed autotransplantation of splenic tissue is technically simple, requires nonexpensive equipment and can be applied in practical public health services in the treatment of childrenβs IT
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