The role of mitochondria in response of wild grass Elymus sibiricus L. seedlings to temperature stress, water deficiency and hydrogen peroxide exposure

The relationship between energetic parameters and content of stress proteins (alternative oxidase, uncoupling protein and HSP70) in wild grass Elymus sibiricus mitochondria during different stress exposure (cold hardening, cold shock, high-temperature stress, water deficiency and oxidative stress) has been studied. It has been shown that influence of mild stress factors (cold hardening and exogenous 0.5 mM hydrogen peroxide treatment) result in adaptive changes related to the increase of activity alternative oxidase and the increase of content such proteins as alternative oxidase, uncoupling protein and HSP70. The comparative analysis of the function of the cultured and wild plants mitochondria in stress conditions has been produced

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men

9-Diazo-10,10-dimethyl-9,10-dihydro-10-sila-2-azaanthracene and 10,10-dimethyl-4′-oxospiro[9,10-dihydro-10-sila-2-azaanthracene-9,2′-azetidine]

The synthesis of the first representative of diazo compounds in the dihydrosilaazaanthracene series and a spiro compound with dihydrosilaazaanthracene and azetidine fragments was realized. © 1990 Plenum Publishing Corporation

9-Diazo-10,10-dimethyl-9,10-dihydro-10-sila-2-azaanthracene and 10,10-dimethyl-4′-oxospiro[9,10-dihydro-10-sila-2-azaanthracene-9,2′-azetidine]

The synthesis of the first representative of diazo compounds in the dihydrosilaazaanthracene series and a spiro compound with dihydrosilaazaanthracene and azetidine fragments was realized. © 1990 Plenum Publishing Corporation