Implementation of state transport policy: regional aspect

The implementation of the transport strategy is based on the general principles of federal relations and takes into account the peculiarities of social-economic development and transport needs of individual regions of the country. The regional aspects of the transport system of Russia development are directly related to the creation of a network of competitive innovation clusters, new regional centers of economic development, also in the Russian Far East. The tasks of the transport complex development common for Russia, depending on the specific conditions of the social-economic development of the regions, have their own specifics, focus and priorities, which are taken into account when developing the priorities of the state transport policy. The main problem is that it is necessary to form an active position of the state at the new stage of development of the country economy to create the conditions for social-economic development, primarily to improve the quality of transport services, reduce the total costs of society that depend on transport, and increase the competitiveness of the domestic transport system, strengthening the innovative, social and environmental orientation of the transport industry development. At the same time, transport as a backbone element of the economy and investment and innovation demand generator for products should be considered as an independent point of economic growth. The purpose of the article is to analyze the implementation of the state transport policy on the Primorsky Territory within the framework of the activities by the Ministry of Transport and Roads of the Primorsky Territory and to identify the main problems and prospects for the development of transport policy main trends in the specified subject of the Russian Federation

Charge carrier transport and deep levels recharge in avalanche s-diodes based on GaAs

Carrier transport and deep-level recharging in semiconductor avalanche S-diode structures have been investigated. Gallium-arsenide n+–π–ν–n structures with the diffusion distribution of deep iron acceptors have been studied. It has been found by solving the continuity and Poisson equations with the use of a commercial software that the electron injection affects the avalanche breakdown voltage and the spacecharge region broadens due to capture of avalanche holes on negative iron ions in the π-region. It is demonstrated by comparing the results of numerical calculation with the experimental data that the S-shaped I–V characteristic of the diffusion avalanche S-diodes cannot be explained within the previously proposed mechanism of capture of avalanche holes on the deep iron levels

Acid Sensitive Ion Channels as Target of Hydrogen Sulfide in Rat Trigeminal Neurons

© 2016, Springer Science+Business Media New York.Hydrogen sulfide (H2S), an endogenous gasotransmitter, was proposed to act as a signaling molecule in a wide variety of pathophysiological processes including inflammation and nociception. Acid-sensing ion channels (ASICs) are voltage-insensitive, proton-gated cation channels activated by extracellular acidosis, and are involved in various pathologies of the nervous system including ischemia, stroke, and migraine. In this study, the effect of the H2S donor-sodium hydrogen sulfide (NaHS) on the firing of trigeminal (TG) nerve was explored using suction electrode recordings in peripheral branches of the TG nerve in isolated rat meninges, and patch clamp recordings of ASIC currents in isolated TG neurons. NaHS (100 μM) increased the action potential frequency of TG nerve and bath application of NaHS increased the amplitude of ASIC currents triggered by focal application of low pH solution on isolated TG neurons. We propose that activation of ASICs by H2S during chronic inflammation process contributes to the increased excitability of the TG system and may be implicated in the generation of nociceptive firing underlying migraine pain

Receptor mechanisms mediating the pro-nociceptive action of hydrogen sulfide in rat trigeminal neurons and meningeal afferents

© 2017 Koroleva, Mustafina, Yakovlev, Hermann, Giniatullin and Sitdikova. Hydrogen sulfide (H 2 S), a well-established member of the gasotransmitter family, is involved in a variety of physiological functions, including pro-nociceptive action in the sensory system. Although several reports have shown that H 2 S activates sensory neurons, the molecular targets of H 2 S action in trigeminal (TG) nociception, implicated in migraine, remains controversial. In this study, using suction electrode recordings, we investigate the effect of the H 2 S donor, sodium hydrosulfide (NaHS), on nociceptive firing in rat meningeal TG nerve fibers. The effect of NaHS was also explored with p atch-clamp and calcium imaging techniques on isolated TG neurons. NaHS dramatically increased the nociceptive firing in TG nerve fibers. This effect was abolished by the TRPV1 inhibitor capsazepine but was partially prevented by the TRPA1 blocker HC 030031. In a fraction of isolated TG neurons, NaHS transiently increased amplitude of capsaicin-induced currents. Moreover, NaHS by itself induced inward currents in sensory neurons, which were abolished by the TRPV1 inhibitor capsazepine suggesting involvement of TRPV1 receptors. In contrast, the inhibitor of TRPA1 receptors HC 030031 did not prevent the NaHS-induced currents. Imaging of a large population of TG neurons revealed that NaHS induced calcium transients in 41% of tested neurons. Interestingly, this effect of NaHS in some neurons was inhibited by the TRPV1 antagonist capsazepine whereas in others it was sensitive to the TRPA1 blocker HC 030031. Our data suggest that both TRPV1 and TRPA1 receptors play a role in the pro-nociceptive action of NaHS in peripheral TG nerve endings in meninges and in somas of TG neurons. We propose that activation of TRPV1 and TRPA1 receptors by H 2 S during neuro-inflammation conditions contributes to the nociceptive firing in primary afferents underlying migraine pain

Spatial structure of phosphorus-containing heterocycles. 23. 2-Phenoxy-1,3,2-dioxaphosphorinanes with four-coordinate phosphorus

1. The change in the valence state of the phosphorus atom influences the orientation with respect to the P-O(Ph) bond in 2-phenoxy-2-oxo(thiono)-1,3,2-dioxaphosphorinanes. 2. An orthogonal conformation is realized in the O-Ph fragment of the compounds investigated, regardless of the hybridization of the phosphorus. © 1980 Plenum Publishing Corporation

Sociological diagnostics of crowdsourcing technology in the practice of regional management

The article proposes a methodology for identifying and analyzing the technology of crowdsourcing, examines the main stages of the formation, and analyzes the implementation of crowdsourcing technology into the practice of regional managemen