The effect of the nonplanarity of heterocyclic analogues of fluorene with the phosphorus atom on spin-orbit interactions

The transition dipole moments P00s for the transitions from the sublevels s = z, y, and x of the triplet electronic states 3A″, which are caused by intramolecular spin-orbit (SO) interactions, are calculated. The calculation is carried out for molecules of heterocyclic analogues of fluorene containing phosphorus and nitrogen (namely, the groups P-H, P-C6H5, and N-H). The influence that the planar and nonplanar models of the molecules, as well as the substituents -C6H5 and -H at the heteroatom (HA), exert on the values of (P00s)2 and on the directions of the corresponding vectors is considered. The values of the component kSO ∼ ∑s (P00s)2 of the radiative deactivation rate constant of the T1 state are calculated. It is ascertained that, in the series of molecules with HA = N, O, P, and S, both the calculated values of kso and those experimentally determined from an analysis of the intensity distribution in fine-structure phosphorescence spectra vary little, whereas the constant of the SO coupling in the heteroatom ςHA increases substantially along this series. The reason for the weak influence of ςHA on values of k so - common for both planar and nonplanar molecules - is found. ©2004 MAIK "Nauka/Interperiodica"

The effect of the nonplanarity of heterocyclic analogues of fluorene with the phosphorus atom on spin-orbit interactions

The transition dipole moments P00s for the transitions from the sublevels s = z, y, and x of the triplet electronic states 3A″, which are caused by intramolecular spin-orbit (SO) interactions, are calculated. The calculation is carried out for molecules of heterocyclic analogues of fluorene containing phosphorus and nitrogen (namely, the groups P-H, P-C6H5, and N-H). The influence that the planar and nonplanar models of the molecules, as well as the substituents -C6H5 and -H at the heteroatom (HA), exert on the values of (P00s)2 and on the directions of the corresponding vectors is considered. The values of the component kSO ∼ ∑s (P00s)2 of the radiative deactivation rate constant of the T1 state are calculated. It is ascertained that, in the series of molecules with HA = N, O, P, and S, both the calculated values of kso and those experimentally determined from an analysis of the intensity distribution in fine-structure phosphorescence spectra vary little, whereas the constant of the SO coupling in the heteroatom ςHA increases substantially along this series. The reason for the weak influence of ςHA on values of k so - common for both planar and nonplanar molecules - is found. ©2004 MAIK "Nauka/Interperiodica"

CLINICAL AND IMMUNOLOGICAL EFFICIENCY OF THE INTERFERON SYNTHESIS INDUCTOR AMONG CHILDREN, SUFFERING FROM THE ACUTE RESPIRATORY INFECTIONS WITH THE ALLERGIC PATHOLOGY

This work presents research findings of the tiloron interferon synthesis application among children, suffering from the allergy and acute respiratory viral infections, witnessing its efficiency and safety. The use of tiloron against the acute respiratory diseases among children with the allergy contributes to much easier run of the viral infection, prevents the exacerbation of the main disease and stimulates the generation of the endogenic interferon.Key words: children, allergic diseases, acute respiratory Viral infections, interferon, tiloron

CLINICAL AND IMMUNOLOGICAL EFFICIENCY OF THE INTERFERON SYNTHESIS INDUCTOR AMONG CHILDREN, SUFFERING FROM THE ACUTE RESPIRATORY INFECTIONS WITH THE ALLERGIC PATHOLOGY

This work presents research findings of the tiloron interferon synthesis application among children, suffering from the allergy and acute respiratory viral infections, witnessing its efficiency and safety. The use of tiloron against the acute respiratory diseases among children with the allergy contributes to much easier run of the viral infection, prevents the exacerbation of the main disease and stimulates the generation of the endogenic interferon.Key words: children, allergic diseases, acute respiratory Viral infections, interferon, tiloron

КЛИНИКО-ИММУНОЛОГИЧЕСКАЯ ЭФФЕКТИВНОСТЬ ИНДУКТОРА СИНТЕЗА ИНТЕРФЕРОНА У ДЕТЕЙ С АЛЛЕРГИЧЕСКОЙ ПАТОЛОГИЕЙ ПРИ ОСТРЫХ РЕСПИРАТОРНЫХ ИНФЕКЦИЯХ

This work presents research findings of the tiloron interferon synthesis application among children, suffering from the allergy and acute respiratory viral infections, witnessing its efficiency and safety. The use of tiloron against the acute respiratory diseases among children with the allergy contributes to much easier run of the viral infection, prevents the exacerbation of the main disease and stimulates the generation of the endogenic interferon.Key words: children, allergic diseases, acute respiratory Viral infections, interferon, tiloron.Представлены результаты исследования применения индуктора синтеза интерферона тилорона у детей с аллергической патологией и острыми респираторными вирусными инфекциями (ОРВИ), свидетельствующие об его эффективности и безопасности. Использование тилорона на фоне ОРВИ у детей с аллергической патологией способствует более лёгкому течению вирусной инфекции, предотвращает обострение основного заболевания и стимулирует выработку эндогенного интерферона. Ключевые слова: дети, аллергические болезни, острые респираторные вирусные инфекции, интерферон, тилорон.(Педиатрическая фармакология. – 2007; 4(1):33-36