Tumor necrosis factor-alpha regulates the expression of inducible costimulator receptor ligand on CD34+ progenitor cells during differentiation into antigen presenting cells

The inducible costimulator receptor (ICOS) is a third member of the CD28 receptor family that regulates T cell activation and function. ICOS binds to a newly identified ligand on antigen presenting cells different from the CD152 ligands CD80 and CD86. We used soluble ICOSIg and a newly developed murine anti-human ICOS ligand (ICOSL) monoclonal antibody to further characterize the ICOSL during ontogeny of antigen presenting cells. In a previous study, we found that ICOSL is expressed on monocytes, dendritic cells, and B cells. To define when ICOSL is first expressed on myeloid antigen presenting cells, we examined ICOSL expression on CD34 cells in bone marrow. We found that CD34bright cells regardless of their myeloid commitment were ICOSL , whereas ICOSL was first expressed when CD34 expression diminished and the myeloid marker CD33 appeared

Spectral fluctuation characterization of random matrix ensembles through wavelets

A recently developed wavelet based approach is employed to characterize the scaling behavior of spectral fluctuations of random matrix ensembles, as well as complex atomic systems. Our study clearly reveals anti-persistent behavior and supports the Fourier power spectral analysis. It also finds evidence for multi-fractal nature in the atomic spectra. The multi-resolution and localization nature of the discrete wavelets ideally characterizes the fluctuations in these time series, some of which are not stationary.Comment: 7 pages, 2 eps figure

Bounds on Heavy-to-Heavy Mesonic Form Factors

We provide upper and lower bounds on the form factors for B -> D, D^* by utilizing inclusive heavy quark effective theory sum rules. These bounds are calculated to leading order in Lambda_QCD/m_Q and alpha_s. The O(alpha_s^2 beta_0) corrections to the bounds at zero recoil are also presented. We compare our bounds with some of the form factor models used in the literature. All the models we investigated failed to fall within the bounds for the combination of form factors (omega^2 - 1)/(4 omega)|omega h_{A2}+h_{A3}|^2.Comment: 27 pages, 10 figure

Moving Beyond Noninformative Priors: Why and How to Choose Weakly Informative Priors in Bayesian Analyses

Throughout the last two decades, Bayesian statistical methods have proliferated throughout ecology and evolution. Numerous previous references established both philosophical and computational guidelines for implementing Bayesian methods. However, protocols for incorporating prior information, the defining characteristic of Bayesian philosophy, are nearly nonexistent in the ecological literature. Here, I hope to encourage the use of weakly informative priors in ecology and evolution by providing a ‘consumer\u27s guide’ to weakly informative priors. The first section outlines three reasons why ecologists should abandon noninformative priors: 1) common flat priors are not always noninformative, 2) noninformative priors provide the same result as simpler frequentist methods, and 3) noninformative priors suffer from the same high type I and type M error rates as frequentist methods. The second section provides a guide for implementing informative priors, wherein I detail convenient ‘reference’ prior distributions for common statistical models (i.e. regression, ANOVA, hierarchical models). I then use simulations to visually demonstrate how informative priors influence posterior parameter estimates. With the guidelines provided here, I hope to encourage the use of weakly informative priors for Bayesian analyses in ecology. Ecologists can and should debate the appropriate form of prior information, but should consider weakly informative priors as the new ‘default’ prior for any Bayesian model

Activity and Process Stability of Purified Green Pepper (Capsicum annuum) Pectin Methylesterase

Pectin methylesterase (PME) from green bell peppers (Capsicum annuum) was extracted and purified by affinity chromatography on a CNBr-Sepharose-PMEI column. A single protein peak with pectin methylesterase activity was observed. For the pepper PME, a biochemical characterization in terms of molar mass (MM), isoelectric points (pI), and kinetic parameters for activity and thermostability was performed. The optimum pH for PME activity at 22 °C was 7.5, and its optimum temperature at neutral pH was between 52.5 and 55.0 °C. The purified pepper PME required the presence of 0.13 M NaCl for optimum activity. Isothermal inactivation of purified pepper PME in 20 mM Tris buffer (pH 7.5) could be described by a fractional conversion model for lower temperatures (55?57 °C) and a biphasic model for higher temperatures (58?70 °C). The enzyme showed a stable behavior toward high-pressure/temperature treatments. Keywords: Capsicum annuum; pepper; pectin methylesterase; purification; characterization; thermal and high-pressure stabilit

Issues in Vendor/Library Relations-The Sales Call

We re-take a coding theoretic notion which goes back to Cl. Shannon: codeword distinguishability. This notion is standard in zero-error information theory, but its bearing is definitely wider and it may help to better understand new forms of coding, e.g. DNA word design. In our approach, the underlying decoding principle is very simple and very general: one decodes by trying to minimise the diversity (in the simplest case the Hamming distance) between a codeword and the output sequence observed at the end of the noisy transmission channel. Symmetrically and equivalently, one may use maximum-similarity decoders and and codeword confusabilities. The operational meaning of codewoord distinguishability is made clear by a reliability criterion, which generalises the well-known criterion on minimum Hamming distance for error-correcting codes. We investigate the formal properties of distinguishabilities versus diversities; these two notions are deeply related, and yet essentially different. An encoding theorem is put forward; as a case study we examine a channel of cryptographic interest

A new CP violating observable for the LHC

We study a new type of CP violating observable that arises in three body decays that are dominated by an intermediate resonance. If two interfering diagrams exist with different orderings of final state particles, the required CP-even phase arises due to the different virtualities of the resonance in each of the two diagrams. This method can be an important tool for accessing new CP phases at the LHC and future colliders.Comment: 22 pages, v2: discussion of charged particle decays and a few references added v3: typos corrected, matches published versio

Some constraints on neutral heavy leptons from flavor-conserving decays of the Z boson

Small neutrino masses can arise in some grand unified models or superstring theories. We consider a model with an enhanced fermion sector containing Dirac neutral heavy leptons. The dependence on the mass and mixing parameters of these new fermions is investigated for several measurable quantities. We study the flavor-conserving leptonic decays of the Z boson and universality breaking in these decays. We also consider the W boson mass dependence on neutral heavy lepton parameters.Comment: 20 pages, Revtex 3.0, 6 uuencoded and compressed postscript figures included. Compressed postscript file of paper, including figures, also available by anonymous ftp at ftp://ftp.physics.carleton.ca/pub/theory/gour/ocipc9411.ps.Z . Accepted for publication in Phys. Rev. D

Phenomenology of neutral heavy leptons

We continue our previous work on the flavour-conserving leptonic decays of the Z boson with neutral heavy leptons (NHL's) in the loops by considering box, vertex, and self-energy diagrams for the muon decay. By inclusion of these loops (they contribute to the input parameter M_W) we can probe the full parameter space spanned by the so-called flavour-conserving mixing parameters ee_(mix), \mu\mu_(mix), \tau\tau_(mix) in a superstring-inspired model of neutrino mass. We compare the results of our analysis with the existing work in this field and conclude that flavour-conserving decays have certain advantages over traditionally considered flavour-violating ones.Comment: submitted to Phys. Rev. D, 30 pages, 9 figures (ps), REVTE