Reversable heat flow through the carbon nanotube junctions

Microscopic mechanisms of externally controlled reversable heat flow through the carbon nanotube junctions (NJ) are studied theoretically. Our model suggests that the heat is transfered along the tube section ${\cal T}$ by electrons ($e$) and holes ($h$) moving ballistically in either in parallel or in opposite directions and accelerated by the bias source-drain voltage $V_{\rm SD}$ (Peltier effect). We compute the Seebeck coefficient $\alpha$, electric $\sigma$ and thermal $\kappa$ conductivities and find that their magnitudes strongly depend on $V_{\rm SD}$ and $V_{\rm G}$. The sign reversal of $\alpha$ versus the sign of $V_{\rm G}$ formerly observed experimentally is interpreted in this work in terms of so-called chiral tunneling phenomena (Klein paradox)

Role of anisotropy for protein-protein encounter

Protein-protein interactions comprise both transport and reaction steps. During the transport step, anisotropy of proteins and their complexes is important both for hydrodynamic diffusion and accessibility of the binding site. Using a Brownian dynamics approach and extensive computer simulations, we quantify the effect of anisotropy on the encounter rate of ellipsoidal particles covered with spherical encounter patches. We show that the encounter rate $k$ depends on the aspect ratios $\xi$ mainly through steric effects, while anisotropic diffusion has only a little effect. Calculating analytically the crossover times from anisotropic to isotropic diffusion in three dimensions, we find that they are much smaller than typical protein encounter times, in agreement with our numerical results.Comment: 4 pages, Revtex with 3 figures, to appear as a Rapid Communication in Physical Review

EVS: Head-up or Head Down? Evaluation of Crew Procedure and Human Factors for Enhanced Vision Systems

Feasibility of an EVS head-down procedure is examined that may provide the same operational benefits under low visibility as the FAA rule on Enhanced Flight Visibility that requires the use of a head-up display (HUD). The main element of the described EVS head-down procedure is the crew procedure within cockpit for flying the approach. The task sharing between Pilot-Flying and Pilot-Not-Flying is arranged such that multiple head-up/head-down transitions can be avoided. The pilot-flying is using the head-down display for acquisition of the necessary visual cues in the EVS image. The pilot-not-flying is monitoring the instruments and looking for the outside visual cues

Pristine CNO abundances from Magellanic Cloud B stars II. Fast rotators in the LMC cluster NGC 2004

We present spectroscopic abundance analyses of three main-sequence B stars in the young Large Magellanic Cloud cluster NGC 2004. All three targets have projected rotational velocities around 130 km/s. Techniques are presented that allow the derivation of stellar parameters and chemical abundances in spite of these high v sin i values. Together with previous analyses of stars in this cluster, we find no evidence among the main-sequence stars for effects due to rotational mixing up to v sin i around 130 km/s. Unless the equatorial rotational velocities are significantly larger than the v sin i values, this finding is probably in line with theoretical expectations. NGC 2004/B30, a star of uncertain evolutionary status located in the Blue Hertzsprung Gap, clearly shows signs of mixing in its atmosphere. To verify the effects due to rotational mixing will therefore require homogeneous analysis of statistically significant samples of low-metallicity main-sequence B stars over a wide range of rotational velocities.Comment: 12 pages, 5 figures, 2 tables; accepted for publication in ApJ (vol. 633, p. 899

Stochastic simulations of cargo transport by processive molecular motors

We use stochastic computer simulations to study the transport of a spherical cargo particle along a microtubule-like track on a planar substrate by several kinesin-like processive motors. Our newly developed adhesive motor dynamics algorithm combines the numerical integration of a Langevin equation for the motion of a sphere with kinetic rules for the molecular motors. The Langevin part includes diffusive motion, the action of the pulling motors, and hydrodynamic interactions between sphere and wall. The kinetic rules for the motors include binding to and unbinding from the filament as well as active motor steps. We find that the simulated mean transport length increases exponentially with the number of bound motors, in good agreement with earlier results. The number of motors in binding range to the motor track fluctuates in time with a Poissonian distribution, both for springs and cables being used as models for the linker mechanics. Cooperativity in the sense of equal load sharing only occurs for high values for viscosity and attachment time.Comment: 40 pages, Revtex with 13 figures, to appear in Journal of Chemical Physic

Minimal hepatic toxicity of Onyx-015: spatial restriction of coxsackie-adenoviral receptor in normal liver.

We administered an adenoviral vector, Onyx-015, into the hepatic artery of patients with metastatic colorectal cancer involving the liver. Thirty-five patients enrolled in this multi-institutional phase I/II trial received up to eight arterial infusions of up to 2 x 10(12) viral particles. Hepatic toxicity was the primary dose-limiting toxicity observed in preclinical models. However, nearly 200 infusions of this adenoviral vector were administered directly into the hepatic artery without significant toxicity. Therefore, we undertook this analysis to determine the impact of repeated adenoviral exposure on hepatic function. Seventeen patients were treated at our institution, providing a detailed data set on the changes in hepatic function following repeated exposure to adenovirus. No changes in hepatic function occurred with the first treatment of Onyx-015 among these patients. Transient increases in transaminase levels occurred in one patient starting with the second infusion and transient increases in bilirubin was observed in two patients starting with the fifth treatment. These changes occurred too early to be explained by viral-mediated lysis of hepatocytes. In addition, viremia was observed starting 3-5 days after the viral infusion in half of the patient, but was not associated with hepatic toxicity. To further understand the basis for the minimal hepatic toxicity of adenoviral vectors, we evaluated the replication of adenovirus in primary hepatocytes and tumor cells in culture and the expression of the coxsackie-adenoviral receptor (CAR) in normal liver and colon cancer metastatic to the liver. We found that adenovirus replicates poorly in primary hepatocytes but replicates efficiently in tumors including tumors derived from hepatocytes. In addition, we found that CAR is localized at junctions between hepatocytes and is inaccessible to hepatic blood flow. CAR is not expressed on tumor vasculature but is expressed on tumor cells. Spatial restriction of CAR to the intercellular space in normal liver and diminished replication of adenovirus in hepatocytes may explain the minimal toxicity observed following repeated hepatic artery infusions with Onyx-015

Mean encounter times for cell adhesion in hydrodynamic flow: analytical progress by dimensional reduction

For a cell moving in hydrodynamic flow above a wall, translational and rotational degrees of freedom are coupled by the Stokes equation. In addition, there is a close coupling of convection and diffusion due to the position-dependent mobility. These couplings render calculation of the mean encounter time between cell surface receptors and ligands on the substrate very difficult. Here we show for a two-dimensional model system how analytical progress can be achieved by treating motion in the vertical direction by an effective reaction term in the mean first passage time equation for the rotational degree of freedom. The strength of this reaction term can either be estimated from equilibrium considerations or used as a fit parameter. Our analytical results are confirmed by computer simulations and allow to assess the relative roles of convection and diffusion for different scaling regimes of interest.Comment: Reftex, postscript figures include

Extreme laser pulses for possible development of boron fusion power reactors for clean and lasting energy

Extreme laser pulses driving non-equilibrium processes in high density plasmas permit an increase of the fusion of hydrogen with the boron isotope 11 by nine orders of magnitude of the energy gains above the classical values. This is the result of initiating the reaction by non-thermal ultrahigh acceleration of plasma blocks by the nonlinear (ponderomotive) force of the laser field, in addition to the avalanche reaction that has now been experimentally and theoretically manifested. The design of a very compact fusion power reactor is scheduled to produce then environmentally fully clean and inexhaustible generation of energy at profitably low costs. The reaction within a volume of cubic millimetres during a nanosecond can only be used for controlled power generation.Comment: 10 pages, 5 fugure