Celebrities in advertising: looking for congruence or for likability?.

Celebrities used as endorsers in advertising are often very popular ones. However, from a cognitive point of view (and more academic one), congruence between brand and celebrity seems to be very important too. Based on affective and cognitive theories to explain endorsement efficiency, congruence between brand and celebrity is shown to be at least as effective as celebrity likability. Moreover the predisposition toward the ad and brand beliefs are mediators of the effects of congruence between brand and celebrity and celebrity likability on ad efficiency.likability; celebrity endorsement; advertisement; congruence; attitude;

Les célébrités dans la publicité : le rôle de la congruence.

La congruence est un concept utilisé dans de nombreux courants de recherche, notamment l’extension de marque, le parrainage ou la publicité. Cette communication vise à démontrer l’intérêt de considérer ce concept selon les deux dimensions définies par Heckler et Childers (1992), à savoir la pertinence et le côté attendu, dans le cas de publicités faisant appel à des célébrités. Une échelle de mesure, adaptée des travaux de Fleck-Dousteyssier, Darpy et Roux (2005) sur le parrainage, est proposée et testée empiriquement.The concept of congruence has been used in many research streams like brand extensions, sponsorship, or advertising. This paper aims to show the interest of considering this concept through the two dimensions proposed by Heckler and Childers (1992): relevancy and expectancy, in the case of celebrity endorsers in advertising. In order to measure this concept, we will then develop and empirically test a scale adapted from the works of Fleck-Dousteyssier, Darpy and Roux (2005) on sponsorship.endossement; celebrities; advertising; endorsement; congruence; célébrités; publicité;

Photodimerization as an alternative to photocrosslinking of nanoparticles: proof of concept with amphiphilic linear polyoxazoline bearing coumarin unit

International audiencePhotosensitive amphiphilic linear polyoxazolines (CoumC 11-POx n) bearing alkyl chain decorated by a UV-active coumarin end group have been synthesized by cationic ring-opening polymerization (CROP). Using DLS and DOSY NMR experiments, their self-assemblies in water were compared with those of homologous photo-unreactiveamphiphilic polyoxazolines (C m-POx n). In both cases, spherical nanoparticles with D H-values around 10 nm were observed. The CoumC 11-POx n nanoparticles were illuminated upon 300 nm inducing the photo-dimerization of the coumarin units located in theinnercompartment of the nanoparticles. Finally, the pros and the cons of the photo-dimerization of linear copolymersrelated to the photo-crosslinking of graft copolymerswere discussed

Guidelines for resident training in veterinary clinical pathology. IV: Laboratory quality management—teaching domains, competencies, and suggested learning outcomes

BACKGROUND : The 2019 ASVCP Education Committee Forum for Discussion, presented at the annual ASVCP/ACVP meeting, identified a need to develop recommendations for teaching laboratory quality management principles in veterinary clinical pathology residency training programs. OBJECTIVES : To present a competency-based framework for teaching laboratory quality management principles in veterinary clinical pathology residency training programs, including entrustable professional activities (EPAs), domains of competence, individual competencies, and learning outcomes. METHODS : A joint subcommittee of the ASVCP Quality Assurance and Laboratory Standards (QALS) and Education Committees executed this project. A draft guideline version was reviewed by the ASVCP membership and shared with selected ACVP committees in early 2022, and a final version was voted upon by the full QALS and Education Committees in late 2022. RESULTS : Eleven domains of competence with relevant individual competencies were identified. In addition, suggested learning outcomes and resource lists were developed. Domains and individual competencies were mapped to six EPAs. CONCLUSIONS : This guideline presents a framework for teaching principles of laboratory quality management in veterinary clinical pathology residency training programs and was designed to be comprehensive yet practical. Guidance on pedagogical terms and possible routes of implementation are included. Recommendations herein aim to improve and support resident training but may require gradual implementation, as programs phase in necessary expertise and resources. Future directions include the development of learning milestones and assessments and consideration of how recommendations intersect with the American College of Veterinary Pathologists training program accreditation and certifying examination.http://www.wileyonlinelibrary.com/journal/vcphj2023Companion Animal Clinical Studie

Precision-medicine findings from the FACE-SZ cohort to develop motivation-enhancing programs in real-world schizophrenia

Background: In people with schizophrenia, major areas of everyday life are impaired, including independent living, productive activities, social relationships and overall quality of life. Enhanced understanding of factors that hinder real-life functioning is vital for treatments to translate into more positive outcomes. Aim: The goal of the present study was to identify factors associated with motivation deficits in real-life schizophrenia, and to assess its contribution to impaired functioning and quality of life. Methods: Based on previous literature and clinical experience, several factors were selected and grouped into factors potentially explaining motivation deficits. Some of these variables were never investigated before in relationship with motivation deficits. Results: In 561 patients with schizophrenia of the national FACE-SZ cohort living in the community, 235 (41.9%) reported severe motivation deficits. These deficits were found to be significantly associated with impaired socially useful activities, psychological and physical quality of life (in almost all domains), alcohol use disorder (aOR = 2.141, p = 0.021), severe nicotine dependence (aOR = 2.906, p < 0.001) independently of age and sex. No significant association was found for body mass index, metabolic syndrome or physical activity level. In the second model, we identified the following modifiable factors associated with motivation deficits: history of suicide attempt (aOR = 2.297, p = 0.001), positive symptoms (aOR = 1.052, p = 0.006), current major depressive episode (aOR = 2.627, p < 0.001), sleep disorders (aOR = 1.474, p = 0.024) and lower medication adherence (aOR = 0.836, p = 0.001) independently of gender, current alcohol use disorder, second-generation antipsychotics and akathisia. No significant association was found for negative symptoms, childhood trauma and inflammation. These results were maintained after removing patients with schizoaffective disorders or those with major depressive disorder. Interpretation: Motivation deficits are frequent and remain persistent unmet need in real-world schizophrenia that should be addressed in future guidelines. Based on our results, literature and clinical experience, we recommend to address in priority major depression, sleep, suicide, positive symptoms (when present and as early as possible) and medication adherence to improve motivation deficits of schizophrenia. © 2022 Informa UK Limited, trading as Taylor & Francis Group.Sorbonne Universités à Paris pour l'Enseignement et la RechercheFondaMental-Cohorte

Self-assembly of photo-responsive amphiphilic copolymers based on polyoxazoline

Trois architectures de copolymères (dibloc, tribloc et hétérogreffé) amphiphiles photo-stimulables à base de polyoxazoline et de groupements photo-sensibles de type coumarine sont étudiées dans ce travail. Ces copolymères s’auto-assemblent en milieu aqueux sous forme de nanoparticules de morphologies sphériques, ovales mais également de nanofibres hélicoïdales de plusieurs micromètres de longueur. Selon les cas, les morphologies sont induites par de la cristallisation des motifs coumarine entre eux ou bien des interactions polyoxazoline-coumarine. Par ailleurs, la photo-réponse des nanoparticules a été examinée après irradiation UV des groupements coumarine, capables de dimériser de manière réversible selon la longueur d’onde utilisée. Elle diffère selon l’architecture du copolymère qui constitue les nanoparticules et donne lieu à des phénomènes de (pré-)photo-dimérisation ou photo-réticulation du cœur de celles-ci avec des réversibilités sous UV variables et un maximum d'efficacité dans le cas des copolymères triblocs. La stabilité de ces auto-assemblages a également été examinée avant et après exposition UV. Dans tous les cas, l’irradiation des nanoparticules améliore leur stabilité en température et dans le temps avec un effet maximal dans le cas de la pré-photodimérisation (tribloc). Enfin, la réticulation et la cristallisation se sont révélées être des freins au piégeage de molécules hydrophobes, illustrées ici avec le Nile Red, alors que les copolymères diblocs se sont révélés être les systèmes les plus efficaces. En somme, les nanoparticules de copolymères triblocs présentent le meilleur compromis entre stabilité, efficacité UV et piégeage.Three photo-responsive amphiphilic copolymer architectures (diblock, triblock and heterografted) based on polyoxazoline and coumarin photo-sensitive units are studied in this work. These copolymers self-assemble in water into spherical or ovalic nanoparticles and also supramicrometer helicoidal nanofibers. Depending on the macromolecular architectures, these morphologies are induced by crystallization of coumarin units or polyoxazoline-coumarin interactions. Moreover, the nanoparticle photo-response is examinated after the UV-exposure of coumarin units, that are able to reversibly dimerize according to the wavelength used. This photo-response varies with the copolymer structure and leads to (previous) photo-dimerization or photo-crosslinking phenomena. These latters present various photo-reversibility behaviors under UV and a maximal efficiency for triblock copolymers. The nanoparticle stability was additionally studied before and after UV-irradiation. In both cases, the nanoparticle stability is improved towards time and temperature with a maximal impact for the previous photo-dimerization (triblock). Finally, the crosslinking and the crystallization appear as brakes for the hydrophobic molecule entrapment, illustrated here by Nile Red, whereas diblock copolymers seem to be the most efficient systems. To conclude, previously photo-dimerized nanoparticles (triblock) are the best way combining stability, UV-efficiency and entrapment

Irrigatys® : un nouveau concept d’irrigation et d’activation en endodontie

L’irrigation en endodontie est conventionnellement réalisée à l’aide d’une seringue et d’une aiguille dont les dimensions et la forme varient. Pour la phase d’irrigation finale, différents dispositifs d’activation de la solution ont été proposés. Cependant, les études ont montré que le nettoyage des canaux n’était jamais complet. Il a également été démontré que l’utilisation d’un volume important de solution était un facteur déterminant de la qualité du traitement endodontique. Dans l’optique d’optimiser cette irrigation, le système Irrigatys® présente un concept innovant alliant les fonctions d’irrigation et d’activation. Il comporte une pièce à main contenant 1 réservoir pour chaque solution, chacun contenant 30 mL de solution, soit l’équivalent de 10 seringues. L’objectif de notre travail est de vérifier l’hypothèse que l’utilisation d’un réservoir de 30 mL facilite l’utilisation d’un grand volume de solution dans le canal sans aucune contrainte technique telle que le rechargement de seringues par exemple. Dans ce but, nous proposons de mettre en place une étude prospective observationnelle concernant le volume de solution utilisé pour chaque traitement en comparant l’utilisation d’une seringue seule versus l’Irrigatys® seul, dans un groupe d’opérateurs constitué par les étudiants du DU d’endodontie, du Master d’endodontie et les praticiens hospitaliers du service du Pr Descroix à la Pitié-Salpêtrière. Nous aborderons d’abord le rôle de l’irrigation dans le parage canalaire. Ensuite, nous présenterons le système Irrigatys®, ses caractéristiques techniques et son mode opératoire. Enfin, nous décrirons l’étude expérimentale se déroulant à la Pitié-Salpêtrière qui permettra de comparer les quantités de volumes de solution utilisées lors d’une irrigation avec seringues manuelles et avec Irrigatys® et analyserons les résultats

Je t&apos;aime... Moi non plus : Exploring the Diversity and Strength of Fan-Idol Relationships in the Field of Music

Abstract The objective of our research is to investigate fandom from a psychological perspective. As a departure from previous research relying on a sociological approach, we focus on the nature and strength of fan-idol relationships. To this end, this study reports the findings from qualitative research carried out in the field of music on how fandom is expressed through fans&apos; interactions with their favourite singer/band, its associated significations and behaviour. We identify four significations: the musician as a brand, as a public personality, as an intimate and as a god. We highlight that fandom is initially an individual phenomenon whereby an individual creates a specific relationship with a musician, and that all fans can be considered valuable consumers independently from the relationship&apos;s strength

Pharmacologie des neuromédiateurs du système nerveux central (application à la thérapeutique vétérinaire)

La pharmacologie des neurotransmetteurs du système nerveux central est complexe. Une grande quantité de médicaments agit en modulant directement ou indirectement les transmissions nerveuses. L'objectif de ce manuscrit est d'organiser les connaissances nécessaires à la compréhension du mécanisme d'action de ces médicaments, et plus particulièrement des anesthésiques au sens large. La première partie est donc consacrée à l'étude de l'anatomie et de la physiologie du système nerveux. Elle comporte également des rappels d'électrophysiologie et de signalisation intra- et inter-cellulaires. La deuxième partie présente les bases de pharmacologie moléculaire des récepteurs des neurotransmetteurs, ainsi que des notions de pharmacologie intégrative sur la modulation des principales transmissions nerveuses (cholinergique, adrénergique, dopaminergique, sérotoninergique, glutamatergique, GABAergique et opioïde). La troisième et dernière partie correspond à un recueil de fiches sur 15 molécules choisies pour leurs fréquences d'utilisation en médecine vétérinaire.MAISONS-ALFORT-Ecole Vétérin (940462302) / SudocSudocFranceF