406 research outputs found
Framing Appropriate Accommodations in Terms of Individual Need: Examining the Fit of Four Approaches to Selecting Test Accommodations of English Language Learners
Providing appropriate test accommodations to most English language learners (ELLs) is important to facilitate meaningful inferences about learning. This study compared teacher large-scale test accommodation recommendations to those from a literature- and practitioner-grounded accommodation selection taxonomy. The taxonomy links student-specific needs, strengths and schooling experiences to large-scale test accommodation recommendations that differentially minimize barriers of access for students with different profiles. A blind panel of experts rated four sets of recommendations for each of 114 ELLs. Results found the taxonomy was a significantly better fit for distinguishing accommodations by student need than teacher recommendations. Further, the fit of teacher recommendations showed no difference when the teacher used a structured data collection procedure to gather profile information about each of their ELLs and when they did not, and teachers’ recommendations were not found to differ significantly from a random set of accommodations. Findings are consistent with previous literature that suggests the task of matching specific accommodations to individual needs, rather than the task of identifying individual needs, is where teachers struggle in recommending appropriate test accommodations
User's Guide to the Energy Charting and Metrics Tool (ECAM)
The intent of this user guide is to provide a brief description of the functionality of the Energy Charting and Metrics (ECAM) tool, including the expanded building re-tuning functionality developed for Pacific Northwest National laboratory (PNNL). This document describes the tool's general functions and features, and offers detailed instructions for PNNL building re-tuning charts, a feature in ECAM intended to help building owners and operators look at trend data (recommended 15-minute time intervals) in a series of charts (both time series and scatter) to analyze air-handler, zone, and central plant information gathered from a building automation system (BAS)
Color Stability of Elastomers for Maxillofacial Appliances
The color stability of polyvinyl chloride, polyurethane, and silicone polymers for maxillofacial applications was determined after accelerated aging using reflectance spectrophotometry. On the basis of color stability after accelerated aging, and ease of processing, several silicone materials were the most promising.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67056/2/10.1177_00220345780570090401.pd
Genetic variation modifies risk for neurodegeneration based on biomarker status
Background: While a great deal of work has gone into understanding the relationship between CSF biomarkers, brain atrophy, and disease progression, less work has attempted to investigate how genetic variation modifies these relationships. The goal of this study was two-fold. First, we sought to identify high-risk v. low-risk individuals based on their CSF tau and Aβ load and characterize these individuals with regard to brain atrophy in an AD-relevant region of interest. Next, we sought to identify genetic variants that modified the relationship between biomarker classification and neurodegeneration.Methods: Participants were categorized based on established cut-points for biomarker positivity. Mixed model regression was used to quantify longitudinal change in the left inferior lateral ventricle. Interaction analyses between single nucleotide polymorphisms (SNPs) and biomarker group status were performed using a genome wide association study (GWAS) approach. Correction for multiple comparisons was performed using the Bonferroni procedure. Results: One intergenic SNP (rs4866650) and one SNP within the SPTLC1 gene (rs7849530) modified the association between amyloid positivity and neurodegeneration. A transcript variant of WDR11-AS1 gene (rs12261764) modified the association between tau positivity and neurodegeneration. These effects were consistent across the two sub-datasets and explained approximately 3% of variance in ventricular dilation. One additional SNP (rs6887649) modified the association between amyloid positivity and baseline ventricular volume, but was not observed consistently across the sub-datasets.Conclusions: Genetic variation modifies the association between AD biomarkers and neurodegeneration. Genes that regulate the molecular response in the brain to oxidative stress may be particularly relevant to neural vulnerability to the damaging effects of amyloid-β
Interval Data Analysis with the Energy Charting and Metrics Tool (ECAM)
Analyzing whole building interval data is an inexpensive but effective way to identify and improve building operations, and ultimately save money. Utilizing the Energy Charting and Metrics Tool (ECAM) add-in for Microsoft Excel, building operators and managers can begin implementing changes to their Building Automation System (BAS) after trending the interval data. The two data components needed for full analyses are whole building electricity consumption (kW or kWh) and outdoor air temperature (OAT). Using these two pieces of information, a series of plots and charts and be created in ECAM to monitor the buildings performance over time, gain knowledge of how the building is operating, and make adjustments to the BAS to improve efficiency and start saving money
Chemical abrasion: the mechanics of zircon dissolution
Chemical abrasion is a technique that combines thermal annealing and partial
dissolution in hydrofluoric acid (HF) to selectively remove
radiation-damaged portions of zircon crystals prior to U–Pb isotopic
analysis, and it is applied ubiquitously to zircon prior to U–Pb isotope
dilution thermal ionization mass spectrometry (ID-TIMS). The mechanics of
zircon dissolution in HF and the impact of different leaching conditions on
the zircon structure, however, are poorly resolved. We present a
microstructural investigation that integrates microscale X-ray computed
tomography (µCT), scanning electron microscopy, and Raman
spectroscopy to evaluate zircon dissolution in HF. We show that µCT
is an effective tool for imaging metamictization and complex dissolution
networks in three dimensions. Acid frequently reaches crystal interiors via
fractures spatially associated with radiation damage zoning and inclusions
to dissolve soluble high-U zones, some inclusions, and material around
fractures, leaving behind a more crystalline zircon residue. Other acid paths
to crystal cores include the dissolution of surface-reaching inclusions and
the percolation of acid across zones with high defect densities. In highly
crystalline samples dissolution is crystallographically controlled with
dissolution proceeding almost exclusively along the c axis. Increasing the
leaching temperature from 180 to 210 ∘C results in
deeper etching textures, wider acid paths, more complex internal dissolution
networks, and greater volume losses. How a grain dissolves strongly depends
on its initial radiation damage content and defect distribution as well as
the size and position of inclusions. As such, the effectiveness of any
chemical abrasion protocol for ID-TIMS U–Pb geochronology is likely
sample-dependent. We also briefly discuss the implications of our findings
for deep-time (U-Th)/He thermochronology.</p
Multimorbidity in bipolar disorder and under-treatment of cardiovascular disease: a cross sectional study
Background: Individuals with serious mental disorders experience poor physical health, especially increased rates of cardiometabolic morbidity and premature morbidity. Recent evidence suggests that individuals with schizophrenia have numerous comorbid physical conditions which may be under-recorded and under-treated but to date very few studies have explored this issue for bipolar disorder.
Methods:We conducted a cross-sectional analysis of a dataset of 1,751,841 registered patients within 314 primary-care practices in Scotland, U.K. Bipolar disorder was identified using Read Codes recorded within electronic medical records. Data on 32 common chronic physical conditions were also assessed. Potential prescribing inequalities were evaluated by analyzing prescribing data for coronary heart disease (CHD) and hypertension.
Results: Compared to controls, individuals with bipolar disorder were significantly less likely to have no recorded physical conditions (OR 0.59, 95% CI 0.54-0.63) and significantly more likely to have one physical condition (OR 1.27, 95% CI 1.16-1.39), two physical conditions (OR 1.45, 95% CI 1.30-1.62) and three or more physical conditions (OR 1.44, 95% CI 1.30-1.64). People with bipolar disorder also had higher rates of thyroid disorders, chronic kidney disease, chronic pain, chronic obstructive airways disease and diabetes but, surprisingly, lower recorded rates of hypertension and atrial fibrillation. People with bipolar disorder and comorbid CHD or hypertension were significantly more likely to be prescribed no antihypertensive or cholesterol-lowering medications compared to controls, and bipolar individuals with CHD or hypertension were significantly less likely to be on 2 or more antihypertensive agents.
Conclusions: Individuals with bipolar disorder are similar to individuals with schizophrenia in having a wide range of comorbid and multiple physical health conditions. They are also less likely than controls to have a primary-care record of cardiovascular conditions such as hypertension and atrial fibrillation. Those with a recorded diagnosis of CHD or hypertension were less likely to be treated with cardiovascular medications and were treated less intensively. This study highlights the high physical healthcare needs of people with bipolar disorder, and provides evidence for a systematic under-recognition and under-treatment of cardiovascular disease in this group
Compulsive buying and branding phenomena
The purpose of this paper was to explore the impact of brand variables such as brand awareness, brand loyalty, brand attachment, and perceived brand quality on compulsive buying behavior. A self-administered questionnaire, containing demographic items and items related to compulsive buying, brand awareness, brand loyalty, brand attachment and perceived quality, was used to collect data. Participants were 269 US university students at a large mid-western university (138 men, 131 women; mean age = 21.96). Data were analyzed using descriptive statistics, t-test and MANOVA/ANOVA. Reliability of all scales was acceptable. In the current study, 18% of the participants were classified as compulsive buyers. Women showed higher compulsive buying tendency than men. Participants with greater compulsive buying tendency scored higher on brand attachment and brand loyalty and lower on brand awareness; there was no difference in scores on perceived brand quality. Results support that brand variables such as brand awareness, brand loyalty, and brand attachment are related to compulsive buying behavior. New perceptions and implications for both academicians and practitioners are provided
- …