Towards Resolving the Gallium Anomaly

A series of experiments studying neutrinos from intense radioactive sources have reported a deficit in the measured event rate which, in combination, has reached a statistical significance of $\sim 5\sigma$. In this paper, we explore avenues for explaining this anomaly, both within the Standard Model and beyond. First, we discuss possible biases in the predicted cross section for the detection reaction $\nu_e + ^{71}\text{Ga} \to e^- + ^{71}\text{Ge}$, which could arise from mismeasurement of the inverse process, $^{71}\text{Ge}$ decay, or from the presence of as yet unknown low-lying excited states of $^{71}\text{Ga}$. The latter would imply that not all $^{71}\text{Ge}$ decays go to the ground state of $^{71}\text{Ga}$, so the extraction of the ground state-to-ground state matrix element relevant for neutrino capture on gallium would be incorrect. Second, we scrutinize the measurement of the source intensity in gallium experiments, and we point out that a $\sim 2\%$ error in the branching ratios for $^{51}\text{Cr}$ decay would be enough to explain the anomaly. Third, we investigate the calibration of the radiochemical germanium extraction efficiency as a possible origin of anomaly. Finally, we outline several new explanations beyond the Standard Model, including scenarios with sterile neutrinos coupled to fuzzy dark matter or to dark energy, as well as a model with decaying sterile neutrinos. We critically assess the viability of these scenarios, and others that have been proposed, in a summary table.Comment: 19 pages, 5 figure

Young people's trauma-related cognitions before and after cognitive processing therapy for post-traumatic stress disorder

Objectives: Cognitive processing therapy (CPT) is a psychotherapy for post‐traumatic stress disorder (PTSD) with a broad evidence base. Change in trauma‐related cognitions is considered its primary working mechanism. When trying to integrate a traumatic event into existing cognitive schemas, the adaptive mechanism is changing the schema (accommodation). However, PTSD patients frequently either change their schemas too much (over‐accommodation), or cognitively distort the event (assimilation). We aimed to test the hypothesized connections between the three types of cognition and symptom load. Design: This study adds to the literature using ‘impact statements’, essays on their trauma‐related thoughts written by patients at the beginning and end of CPT, to investigate cognitive change and its relationship to symptomatic outcome. Methods: We analysed statements written by 31 adolescents and young adults who received developmentally adapted CPT (a longer treatment where CPT is the core component) in a randomized controlled trial. Results: As expected, post‐CPT statements contained more accommodated and fewer over‐accommodated and assimilated clauses than pre‐CPT statements. Correlations between cognition frequencies and concurrent symptom load were as expected for assimilation, and, in part, over‐accommodation and accommodation. Decreased PTSD and depressive symptoms were correlated with increased accommodated thoughts. For over‐accommodation and assimilation, however, expected correlations could not be shown. Conclusions: Our results support the notion that cognitive change is an important mechanism of change in CPT in a sample of younger, non‐English‐speaking clients

Prediction of clinical response to drugs in ovarian cancer using the chemotherapy resistance test (CTR-test)

Background In order to validate if the test result of the Chemotherapy Resistance Test (CTR-Test) is able to predict the resistances or sensitivities of tumors in ovarian cancer patients to drugs, the CTR-Test result and the corresponding clinical response of individual patients were correlated retrospectively. Results were compared to previous recorded correlations. Methods The CTR-Test was performed on tumor samples from 52 ovarian cancer patients for specific chemotherapeutic drugs. Patients were treated with monotherapies or drug combinations. Resistances were classified as extreme (ER), medium (MR) or slight (SR) resistance in the CTR-Test. Combination treatment resistances were transformed by a scoring system into these classifications. Results Accurate sensitivity prediction was accomplished in 79% of the cases and accurate prediction of resistance in 100% of the cases in the total data set. The data set of single agent treatment and drug combination treatment were analyzed individually. Single agent treatment lead to an accurate sensitivity in 44% of the cases and the drug combination to 95% accuracy. The detection of resistances was in both cases to 100% correct. ROC curve analysis indicates that the CTR-Test result correlates with the clinical response, at least for the combination chemotherapy. Those values are similar or better than the values from a publication from 1990. Conclusions Chemotherapy resistance testing in vitro via the CTR-Test is able to accurately detect resistances in ovarian cancer patients. These numbers confirm and even exceed results published in 1990. Better sensitivity detection might be caused by a higher percentage of drug combinations tested in 2012 compared to 1990. Our study confirms the functionality of the CTR-Test to plan an efficient chemotherapeutic treatment for ovarian cancer patients

Sharing more than friendship - nasal colonization with coagulase-positive staphylococci (CPS) and co-habitation aspects of dogs and their owners

Background Since the relationship between dogs and their owners has changed, and dogs moved from being working dogs to family members in post-industrial countries, we hypothesized that zoonotic transmission of opportunistic pathogens like coagulase positive staphylococci (CPS) is likely between dogs and their owners. Methodology/Principal Findings CPS- nasal carriage, different aspects of human-to-dog relationship as well as potential interspecies transmission risk factors were investigated by offering nasal swabs and a questionnaire to dog owners (108) and their dogs (108) at a dog show in 2009. S. aureus was found in swabs of 20 (18.5%) humans and two dogs (1.8%), and spa types which correspond to well known human S. aureus lineages dominated (e.g. CC45, CC30 and CC22). Multilocus sequence typing (MLST) of the two canine strains revealed ST72 and ST2065 (single locus variant of ST34). Fifteen dogs (13.9%) and six owners (5.6%) harboured S. pseudintermedius, including one mecA-positive human isolate (MRSP). Pulsed field gel electrophoresis (PFGE) revealed that one dog/owner pair harboured indistinguishable S. pseudintermedius- isolates of ST33. Ten (48%) of the 21 S. pseudintermedius-isolates showed resistance towards more than one antimicrobial class. 88.9% of the dog owners reported to allow at least one dog into the house, 68.5% allow the dog(s) to rest on the sofa, 39.8% allow their dogs to come onto the bed, 93.5% let them lick their hands and 52.8% let them lick their face. Bivariate analysis of putative risk factors revealed that dog owners who keep more than two dogs have a significantly higher chance of being colonized with S. pseudintermedius than those who keep 1–2 dogs (p<0.05). Conclusions/Recommendations In conclusion, CPS transmission between dog owners and their dogs is possible. Further investigation regarding interspecies transmission and the diverse adaptive pathways influencing the epidemiology of CPS (including MRSA and MRSP) in different hosts is needed

Seroprevalence of SARS-CoV-2 antibodies, associated factors, experiences and attitudes of nursing home and home healthcare employees in Switzerland

BACKGROUND Many studies in hospital settings exist and have shown healthcare employees to be particularly exposed to SARS-CoV-2. While research focused on hospital staff, little evidence exists for employees in nursing homes and home care. The aims of this study were to assess the seroprevalence in nursing homes and home care employees in the Canton of Zurich, compare it to the general population, assess factors associated with seropositivity and explore the perspective of the employees regarding how the pandemic changed their daily work. METHODS This cross-sectional study is part of the national Corona Immunitas research program of coordinated, seroprevalence studies in Switzerland. Six nursing homes and six home healthcare organizations providing at home care services in Zurich were selected and 296 and 131 employees were recruited, respectively. Assessments included standardized questionnaires, blood sampling for antibodies, and additional work-specific questions. All participants were recruited between 21st September and 23rd October 2020, before the second wave of the pandemic hit Switzerland, and were possibly exposed to SARS-CoV-2 at their work during the first wave in spring 2020. RESULTS Seroprevalence of SARS-CoV-2 was 14.9% (95% CI 11.1%-19.6%; range 3.8% to 24.4%) for nursing home employees and 3.8% (95% CI 1.4-9.1%; range 0% to 10%) for home healthcare employees, compared to the general population of Zurich at 3.5% in September 2020 for those aged 20-64. Nurses were 2.6 times more likely to have SARS-CoV-2 antibodies than those employees who were not nurses (95% CI 1.1-6.2). The employees (nursing homes vs. home healthcare) perceived the implementation of general safety measures (44.9% vs. 57.3%) and wearing masks during work (36.8% vs. 43.5%), especially due to the limited communication with residents/clients, as the most crucial changes. CONCLUSIONS Nursing home employees who worked through SARS-CoV-2 outbreaks at their work were substantially more affected by SARS-CoV-2 infection compared to the general population and to home healthcare employees who similarly worked through outbreaks in their communities. Employees reported that important resources to cope with the burdensome changes they perceived in their daily work were personal resources and team support. TRIAL REGISTRATION Current Controlled Trials ISRCTN18181860 dated 09/07/2020. Retrospectively registered

Wer organisiert die "Entbehrlichen"? Viertelgestalterinnen und Viertelgestalter in benachteiligten Stadtquartieren

Auch wenn die Zivilgesellschaft in sozial benachteiligten Stadtvierteln häufig kaum sichtbar ist, gibt es wichtige Ausnahmen: Viertelgestalter_innen sind mit unermüdlicher Tatkraft bürgerschaftlich aktiv. Im Buch werden acht dieser außergewöhnlichen Menschen in ausführlichen Portraits vorgestellt. Wie kamen sie zu ihrer Rolle, welche Motive treiben sie in ihrem Engagement an, welche Wertvorstellungen vertreten sie? Die Studie ermöglicht detaillierte Einblicke in die Funktionsweise von Zivilgesellschaft in sozial schwachen Stadtteilen. Sie benennt Hindernisse und Schwierigkeiten für die Aktiven - zeigt aber auch Perspektiven, wie das partizipative Versprechen der modernen Bürgergesellschaft für sozial Benachteiligte eingelöst werden könnte.Civil engagement on the fringe of society - this volume shows what brings people in socially disadvantaged urban districts to engage in the civil society

The Effect of Biochemical Remission on Bone Metabolism in Cushing's Syndrome: A 2‐Year Follow‐Up Study

Endogenous Cushing's syndrome (CS) is a rare cause of secondary osteoporosis. The long‐term consequences for bone metabolism after successful surgical treatment remain largely unknown. We assessed bone mineral density and fracture rates in 89 patients with confirmed Cushing's syndrome at the time of diagnosis and 2 years after successful tumor resection. We determined five bone turnover markers at the time of diagnosis, 1 and 2 years postoperatively. The bone turnover markers osteocalcin, intact procollagen‐IN‐propeptide (PINP), alkaline bone phosphatase, CTX‐I, and TrAcP 5b were measured in plasma or serum by chemiluminescent immunoassays. For comparison, 71 sex‐, age‐, and body mass index (BMI)‐matched patients in whom Cushing's syndrome had been excluded were studied. None of the patients received specific osteoanabolic treatment. At time of diagnosis, 69% of the patients had low bone mass (mean T‐score = −1.4 ± 1.1). Two years after successful surgery, the T‐score had improved in 78% of patients (mean T‐score 2 years postoperatively −1.0 ± 0.9). The bone formation markers osteocalcin and intact PINP were significantly decreased at time of diagnosis (p ≤ 0.001 and p = 0.03, respectively), and the bone resorption marker CTX‐I and TrAcP 5b increased. Postoperatively, the bone formation markers showed a three‐ to fourfold increase 1 year postoperatively, with a moderate decline thereafter. The bone resorption markers showed a similar but less pronounced course. This study shows that the phase immediately after surgical remission from endogenous CS is characterized by a high rate of bone turnover resulting in a striking net increase in bone mineral density in the majority of patients

Wer organisiert die "Entbehrlichen"?

Auch wenn die Zivilgesellschaft in sozial benachteiligten Stadtvierteln häufig kaum sichtbar ist, gibt es wichtige Ausnahmen: Viertelgestalter_innen sind mit unermüdlicher Tatkraft bürgerschaftlich aktiv. Im Buch werden acht dieser außergewöhnlichen Menschen in ausführlichen Portraits vorgestellt. Wie kamen sie zu ihrer Rolle, welche Motive treiben sie in ihrem Engagement an, welche Wertvorstellungen vertreten sie? Die Studie ermöglicht detaillierte Einblicke in die Funktionsweise von Zivilgesellschaft in sozial schwachen Stadtteilen. Sie benennt Hindernisse und Schwierigkeiten für die Aktiven - zeigt aber auch Perspektiven, wie das partizipative Versprechen der modernen Bürgergesellschaft für sozial Benachteiligte eingelöst werden könnte

Consensus Minimal Dataset for Pediatric Emergency Medicine in Switzerland.

OBJECTIVES Standardized, harmonized data sets generated through routine clinical and administrative documentation can greatly accelerate the generation of evidence to improve patient care. The objective of this study was to define a pediatric emergency medicine (PEM) minimal dataset for Switzerland (Swiss PEM minimal dataset) and to contribute a subspecialty module to a national pediatric data harmonization process (SwissPedData). METHODS We completed a modified Delphi survey, inviting experts from all major Swiss pediatric emergency departments (PEDs). RESULTS Twelve experts from 10 Swiss PEDs, through 3 Delphi survey rounds and a moderated e-mail discussion, suggested a subspecialty module for PEM to complement the newly developed SwissPedData main common data model (CDM). The PEM subspecialty CDM contains 28 common data elements (CDEs) specific to PEM. Additional CDEs cover PEM-specific admission processes (type of arrival), timestamps (time of death), greater details on investigations and treatments received at the PED, and PEM procedures (eg, procedural sedation). In addition to the 28 CDEs specific to PEM, 43 items from the SwissPedData main CDM were selected to create a Swiss PEM minimal dataset. The final Swiss PEM minimal dataset was similar in scope and content to the registry of the Pediatric Emergency Care Applied Research Network. CONCLUSIONS A practical minimal dataset for PEM in Switzerland was developed through recognized consensus methodology. The Swiss PEM minimal dataset developed by Swiss PEM experts will facilitate international data sharing for PEM research and quality improvement projects

THE NATURAL HISTORY OF MODEL ORGANISMS Insights into the evolution of social systems and species from baboon studies

International audienceBaboons, members of the genus Papio, comprise six closely related species distributed throughout sub-Saharan Africa and southwest Arabia. The species exhibit more ecological flexibility and a wider range of social systems than many other primates. This article summarizes our current knowledge of the natural history of baboons and highlights directions for future research. We suggest that baboons can serve as a valuable model for complex evolutionary processes, such as speciation and hybridization. The evolution of baboons has been heavily shaped by climatic changes and population expansion and fragmentation in the African savanna environment, similar to the processes that acted during human evolution. With accumulating long-term data, and new data from previously understudied species, baboons are ideally suited for investigating the links between sociality, health, longevity and reproductive success. To achieve these aims, we propose a closer integration of studies at the proximate level, including functional genomics, with behavioral and ecological studies