455 research outputs found
Young-onset dementia and the need for specialist care: a national and international perspective
OBJECTIVES: Receiving a timely and accurate diagnosis and gaining access to age-appropriate support for younger people living with dementia (YPD) remains a challenge both in the UK and internationally because the focus of most dementia services is primarily upon the needs of older people. The political case to improve services for YPD depends upon the establishment of an understanding of the clinical symptoms, an unequivocal evidence base about need and an accurate evaluation of the size of the population affected. This short report assesses the evidence base from international studies regarding service design and delivery. The goal is to raise awareness, advance best practice and galvanise the international community to address the serious underfunding and underprovision of care for this marginalised group. CONCLUSION: The current evidence suggests that there are universal problems, regardless of continent, with delays to diagnosis and poor understanding of optimum models for service provision and long-term care
A religious upbringing reduces the influence of genetic factors on disinhibition: Evidence for interaction between genotype and environment on personality
High scale impact in alignment and decoupling in two-Higgs doublet models
The two-Higgs doublet model (2HDM) provides an excellent benchmark to study
physics beyond the Standard Model (SM). In this work we discuss how the
behaviour of the model at high energy scales causes it to have a scalar with
properties very similar to those of the SM -- which means the 2HDM can be seen
to naturally favor a decoupling or alignment limit. For a type II 2HDM, we show
that requiring the model to be theoretically valid up to a scale of 1 TeV, by
studying the renormalization group equations (RGE) of the parameters of the
model, causes a significant reduction in the allowed magnitude of the quartic
couplings. This, combined with -physics bounds, forces the model to be
naturally decoupled. As a consequence, any non-decoupling limits in type II,
like the wrong-sign scenario, are excluded. On the contrary, even with the very
constraining limits for the Higgs couplings from the LHC, the type I model can
deviate substantially from alignment. An RGE analysis similar to that made for
type II shows, however, that requiring a single scalar to be heavier than about
500 GeV would be sufficient for the model to be decoupled. Finally, we show
that not only a 2HDM where the lightest of the CP-even scalars is the 125 GeV
one does not require new physics to be stable up to the Planck scale but this
is also true when the heavy CP-even Higgs is the 125 GeV and the theory has no
decoupling limit for the type I model.Comment: 28 pages, 19 figure
Measuring Accuracy of Automated Parsing and Categorization Tools and Processes in Digital Investigations
This work presents a method for the measurement of the accuracy of evidential
artifact extraction and categorization tasks in digital forensic
investigations. Instead of focusing on the measurement of accuracy and errors
in the functions of digital forensic tools, this work proposes the application
of information retrieval measurement techniques that allow the incorporation of
errors introduced by tools and analysis processes. This method uses a `gold
standard' that is the collection of evidential objects determined by a digital
investigator from suspect data with an unknown ground truth. This work proposes
that the accuracy of tools and investigation processes can be evaluated
compared to the derived gold standard using common precision and recall values.
Two example case studies are presented showing the measurement of the accuracy
of automated analysis tools as compared to an in-depth analysis by an expert.
It is shown that such measurement can allow investigators to determine changes
in accuracy of their processes over time, and determine if such a change is
caused by their tools or knowledge.Comment: 17 pages, 2 appendices, 1 figure, 5th International Conference on
Digital Forensics and Cyber Crime; Digital Forensics and Cyber Crime, pp.
147-169, 201
The relative contribution of genes and environment to alcohol use in early adolescents: Are similar factors related to initiation of alcohol use and frequency of drinking?
Item does not contain fulltextBackground: The present study assessed the relative contribution of genes and environment to individual differences in initiation of alcohol use and frequency of drinking among early adolescents and examined the extent to which the same genetic and environmental factors influence both individual differences in initiation of alcohol use and frequency of drinking.
Methods: Questionnaire data collected by the Netherlands Twin Register were available for 694 twin pairs aged of 12 to 15âyears. Bivariate genetic model fitting analyses were conducted inmx. We modeled the variance of initiation of alcohol use and frequency of drinking as a function of three influences: genetic effects, common environmental effects, and unique environmental effects. Analyses were performed conditional on sex.
Results: Findings indicated that genetic factors were most important for variation in early initiation of alcohol use (83% explained variance in males and 70% in females). There was a small contribution of common environment (2% in males, 19% in females). In contrast, common environmental factors explained most of the variation in frequency of drinking (82% in males and females). In males the association between initiation and frequency was explained by common environmental factors influencing both phenotypes. In females, there was a large contribution of common environmental factors that influenced frequency of drinking only. There was no evidence that different genetic or common environmental factors operated in males and females.
Conclusion: Different factors were involved in individual differences in early initiation of alcohol use and frequency of drinking once adolescents have started to use alcohol
The Familial Clustering of Age at Menarche in Extended Twin Families
The timing of puberty is complex, possibly involving many genetic factors that may interact with environmental influences. Familial resemblance for age at menarche was studied in a sample of 4,995 female twins, 1,296 sisters, 2,946 mothers and 635 female spouses of male twins. They had indicated their age at menarche as part of a larger longitudinal survey. We assessed assortative mating for age at menarche, geneâenvironment interaction effects and estimated the heritability of individual differences in pubertal timing. There was significant evidence of geneâenvironment interaction, accounting for 1.5% of the variance. There was no indication of consistent mate assortment on age at menarche. Individual differences in age at menarche are highly heritable, with additive genetic factors explaining at least 70% of the true variation. An additional 1.5% of the variation can be explained by a genotypeâenvironment interaction effect where environmental factors are more important in individuals genetically predisposed for late menarche
SDSS J092455.87+021924.9: an Interesting Gravitationally Lensed Quasar from the Sloan Digital Sky Survey
We report the discovery of a new gravitationally lensed quasar from the Sloan
Digital Sky Survey, SDSS J092455.87+021924.9 (SDSS J0924+0219). This object was
selected from among known SDSS quasars by an algorithm that was designed to
select another known SDSS lensed quasar (SDSS 1226-0006A,B). Five separate
components, three of which are unresolved, are identified in photometric
follow-up observations obtained with the Magellan Consortium's 6.5m Walter
Baade telescope at Las Campanas Observatory. Two of the unresolved components
(designated A and B) are confirmed to be quasars with z=1.524; the velocity
difference is less than 100 km sec^{-1} according to spectra taken with the W.
M. Keck Observatory's Keck II telescope on Mauna Kea. A third stellar
component, designated C, has the colors of a quasar with redshift similar to
components A and B. The maximum separation of the point sources is 1.78". The
other two sources, designated G and D, are resolved. Component G appears to be
the best candidate for the lensing galaxy. Although component D is near the
expected position of the fourth lensed component in a four image lens system,
its properties are not consistent with being the image of a quasar at z~1.5.
Nevertheless, the identical redshifts of components A and B and the presence of
component C strongly suggest that this object is a gravitational lens. Our
observations support the idea that a foreground object reddens the fourth
lensed component and that another unmodeled effect (such as micro- or
milli-lensing) demagnificates it, but we cannot rule out the possibility that
SDSS0924+0219 is an example of the relatively rare class of ``three component''
lens systems.Comment: 24 pages, 6 figures, accepted by A
Cortical depth dependent functional responses in humans at 7T: improved specificity with 3D GRASE
Ultra high fields (7T and above) allow functional imaging with high contrast-to-noise ratios and improved spatial resolution. This, along with improved hardware and imaging techniques, allow investigating columnar and laminar functional responses. Using gradient-echo (GE) (T2* weighted) based sequences, layer specific responses have been recorded from human (and animal) primary visual areas. However, their increased sensitivity to large surface veins potentially clouds detecting and interpreting layer specific responses. Conversely, spin-echo (SE) (T2 weighted) sequences are less sensitive to large veins and have been used to map cortical columns in humans. T2 weighted 3D GRASE with inner volume selection provides high isotropic resolution over extended volumes, overcoming some of the many technical limitations of conventional 2D SE-EPI, whereby making layer specific investigations feasible. Further, the demonstration of columnar level specificity with 3D GRASE, despite contributions from both stimulated echoes and conventional T2 contrast, has made it an attractive alternative over 2D SE-EPI. Here, we assess the spatial specificity of cortical depth dependent 3D GRASE functional responses in human V1 and hMT by comparing it to GE responses. In doing so we demonstrate that 3D GRASE is less sensitive to contributions from large veins in superficial layers, while showing increased specificity (functional tuning) throughout the cortex compared to GE
- âŠ