Evaluación del uso de los servicios in situ de las bibliotecas de barrio: un estudio a nivel nacional de usuarios de minorías étnicas y mayorías blancas de bajos ingresos usando instrumentos personales de recogida de datos

The practice of aggregating public library use data to a system-wide level (central library and branches) can mask the library needs of more specific groups of users. This article introduces a study that addressed this need, by identifying libraries serving majority White/low income and majority-minority markets, and surveying those populations to identify types and levels of use. The study is critical for current library research and practices for these reasons: (1) the increasing diversity in race/ ethnicity and languages spoken in U.S. communities; (2) low circulation rates exacerbated by increased Internet use; (3) mere existence of a library is critical to optimize use by populations without the library and reading experience; and (4) the recent release of the U.S. Public Library Geographic Database with neighborhood level census and library use data for all U.S. library jurisdictions. The methodologies developed offer potential for the collection of critical data for the public librarian of todayLa costumbre de presentar los datos totales sobre el uso de la biblioteca a nivel de todo un sistema bibliotecario (es decir, incluyendo tanto la biblioteca central como las sucursales) puede enmascarar las necesidades de los grupos de usua-rios más específicos. Este artículo presenta un estudio que intenta resolver este problema identificando las bibliotecas que sirven a minorías étnicas o a mayorías de raza blanca con bajos ingresos y examinando estas poblaciones para evaluar tipos y niveles de uso. Este estudio es muy importante para la investigación y práctica diaria de las bibliotecas por estas razones: (1) incremento de la diversidad de razas/etnias y lenguas habladas en los Estados Unidos, (2) bajos índices de préstamo agravados por el uso de Internet, (3) la mera existencia de una biblioteca es vital para fomentar el uso por poblaciones sin una tradición bibliotecaria o hábito de lectura y (4) la reciente publicación de la Base de Datos Geográfica de las Bibliotecas Públicas con datos sobre el uso de las bibliotecas y del censo demográfico a nivel de barrios para todos los sistemas bibliotecarios estadou-nidenses. Las metodologías desarrolladas ofrecen posibilidades para la colección de datos importantes para el bibliotecario de hoy dí

Autoimmunity in Immunodeficiency

Primary immunodeficiencies (PID) comprise a diverse group of clinical disorders with varied genetic defects. Paradoxically, a substantial proportion of PID patients develop autoimmune phenomena in addition to having increased susceptibility to infections from their impaired immunity. Although much of our understanding comes from data gathered through experimental models, there are several well-characterized PID that have improved our knowledge of the pathways that drive autoimmunity. The goals of this review will be to discuss these immunodeficiencies and to review the literature with respect to the proposed mechanisms for autoimmunity within each put forth to date

ACRF Ingest Software Status: New, Current, and Future - February 2007

The purpose of this report is to provide status of the ingest software used to process instrument data for the Atmospheric Radiation Measurement Program Climate Research Facility (ACRF). The report is divided into 4 sections: (1) for news about ingests currently under development, (2) for current production ingests, (3) for future ingest development plans, and (4) for information on retired ingests

Reliability-Based Electronics Shielding Design Tools

Shielding design on large human-rated systems allows minimization of radiation impact on electronic systems. Shielding design tools require adequate methods for evaluation of design layouts, guiding qualification testing, and adequate follow-up on final design evaluation

Genetic Studies of a Cluster of Acute Lymphoblastic Leukemia Cases in Churchill County, Nevada

OBJECTIVE: In a study to identify exposures associated with 15 cases of childhood leukemia, we found levels of tungsten, arsenic, and dichlorodiphenyldichloroethylene in participants to be higher than mean values reported in the National Report on Human Exposure to Environmental Chemicals. Because case and comparison families had similar levels of these contaminants, we conducted genetic studies to identify gene polymorphisms that might have made case children more susceptible than comparison children to effects of the exposures. DESIGN: We compared case with comparison children to determine whether differences existed in the frequency of polymorphic genes, including genes that code for enzymes in the folate and purine pathways. We also included discovery of polymorphic forms of genes that code for enzymes that are inhibited by tungsten: xanthine dehydrogenase, sulfite oxidase (SUOX gene), and aldehyde oxidase. PARTICIPANTS: Eleven case children were age- and sex-matched with 42 community comparison children for genetic analyses. Twenty parents of case children also contributed to the analyses. RESULTS: One bilalleleic gene locus in SUOX was significantly associated with either case or comparison status, depending on which alleles the child carried (without adjusting for multiple comparisons). CONCLUSIONS: Although genetic studies did not provide evidence that a common agent or genetic susceptibility factor caused the leukemias, the association between a SUOX gene locus and disease status in the presence of high tungsten and arsenic levels warrants further investigation. RELEVANCE: Although analyses of community clusters of cancer have rarely identified causes, these findings have generated hypotheses to be tested in subsequent studies

Change-of-state Paradigms and the middle in Kinyarwanda

This paper investigates the derivational relationships among members of verbal paradigms in Kinyarwanda (Bantu JD.61; Rwanda) by pursuing two interrelated goals. First, I describe a variety of derivational strategies for marking transitive and intransitive variants in change-of-state verb paradigms. Second, I focus on the detransitivizing morpheme –ik which serves as one possible marking for intransitive members of these paradigms. Ultimately, I argue that this morpheme is a marker of middle voice, and the variety of readings which appear with this form can be subsumed under a single operation of argument suppression. Finally, I provide a discussion of reflexives and the apparent lack of a reflexive reading with –ik by arguing that this reading is blocked by either lexical reflexives or the reflexive prefix i–

Expanding the Y Dwarf Census with Spitzer Follow-up of the Coldest CatWISE Solar Neighborhood Discoveries

We present Spitzer 3.6 and 4.5 μm follow-up of 170 candidate extremely cool brown dwarfs newly discovered via the combination of Wide-field Infrared Survey Explorer (WISE) and NEOWISE imaging at 3–5 μm. CatWISE, a joint analysis of archival WISE and NEOWISE data, has improved upon the motion measurements of AllWISE by leveraging a >10× time baseline enhancement, from 0.5 yr (AllWISE) to 6.5 yr (CatWISE). As a result, CatWISE motion selection has yielded a large sample of previously unrecognized brown dwarf candidates, many of which have archival detections exclusively in the WISE 4.6 μm (W2) channel, suggesting that they could be both exceptionally cold and nearby. Where these objects go undetected in WISE W1 (3.4 μm), Spitzer can provide critically informative detections at 3.6 μm. Of our motion-confirmed discoveries, 17 have a best-fit Spitzer [3.6]–[4.5] color most consistent with spectral type Y. It is likely that CWISEP J144606.62–231717.8 (μ ≈ 1.”3 yr⁻¹) is the reddest, and therefore potentially coldest, member of our sample with a very uncertain [3.6]–[4.5] color of 3.71 ± 0.44 mag. We also highlight our highest proper-motion discovery, WISEA J153429.75–104303.3, with μ ≈ 2.”7 yr⁻¹. Given that the prior list of confirmed and presumed Y dwarfs consists of just 27 objects, the Spitzer follow-up presented in this work has substantially expanded the sample of identified Y dwarfs. Our new discoveries thus represent significant progress toward understanding the bottom of the substellar mass function, investigating the diversity of the Y dwarf population, and selecting optimal brown dwarf targets for James Webb Space Telescope spectroscopy

Retinal glycoprotein enrichment by concanavalin a enabled identification of novel membrane autoantigen synaptotagmin-1 in equine recurrent uveitis.

Complete knowledge of autoantigen spectra is crucial for understanding pathomechanisms of autoimmune diseases like equine recurrent uveitis (ERU), a spontaneous model for human autoimmune uveitis. While several ERU autoantigens were identified previously, no membrane protein was found so far. As there is a great overlap between glycoproteins and membrane proteins, the aim of this study was to test whether pre-enrichment of retinal glycoproteins by ConA affinity is an effective tool to detect autoantigen candidates among membrane proteins. In 1D Western blots, the glycoprotein preparation allowed detection of IgG reactions to low abundant proteins in sera of ERU patients. Synaptotagmin-1, a Ca2+-sensing protein in synaptic vesicles, was identified as autoantigen candidate from the pre-enriched glycoprotein fraction by mass spectrometry and was validated as a highly prevalent autoantigen by enzyme-linked immunosorbent assay. Analysis of Syt1 expression in retinas of ERU cases showed a downregulation in the majority of ERU affected retinas to 24%. Results pointed to a dysregulation of retinal neurotransmitter release in ERU. Identification of synaptotagmin-1, the first cell membrane associated autoantigen in this spontaneous autoimmune disease, demonstrated that examination of tissue fractions can lead to the discovery of previously undetected novel autoantigens. Further experiments will address its role in ERU pathology