On Time-Bounded Incompressibility of Compressible Strings and Sequences

For every total recursive time bound $t$, a constant fraction of all compressible (low Kolmogorov complexity) strings is $t$-bounded incompressible (high time-bounded Kolmogorov complexity); there are uncountably many infinite sequences of which every initial segment of length $n$ is compressible to $\log n$ yet $t$-bounded incompressible below ${1/4}n - \log n$; and there are countable infinitely many recursive infinite sequence of which every initial segment is similarly $t$-bounded incompressible. These results are related to, but different from, Barzdins's lemma.Comment: 9 pages, LaTeX, no figures, submitted to Information Processing Letters. Changed and added a Barzdins-like lemma for infinite sequences with different quantification oreder, a fixed constant, and uncountably many sequence

Clinical implications of food-drug interactions with small-molecule kinase inhibitors

During the past two decades, small-molecule kinase inhibitors have proven to be valuable in the treatment of solid and haematological tumours. However, because of their oral administration, the intrapatient and interpatient exposure to small-molecule kinase inhibitors (SMKIs) is highly variable and is affected by many factors, such as concomitant use of food and herbs. Food-drug interactions are capable of altering the systemic bioavailability and pharmacokinetics of these drugs. The most important mechanisms underlying food-drug interactions are gastrointestinal drug absorption and hepatic metabolism through cytochrome P450 isoenzymes. As food-drug interactions can lead to therapy failure or severe toxicity, knowledge of these interactions is essential. This Review provides a comprehensive overview of published studies involving food-drug interactions and herb-drug interactions for all registered SMKIs up to Oct 1, 2019. We critically discuss US Food and Drug Administration (FDA) and European Medicines Agency (EMA) guidelines concerning food-drug interactions and offer clear recommendations for their management in clinical practice

EARLY DEVELOPMENT OF SYNCHRONY IN CORTICAL ACTIVATIONS IN THE HUMAN

Peer reviewe

Lithium atom interferometer using laser diffraction : description and experiments

We have built and operated an atom interferometer of the Mach-Zehnder type. The atomic wave is a supersonic beam of lithium seeded in argon and the mirrors and beam-splitters for the atomic wave are based on elastic Bragg diffraction on laser standing waves at 671 nm. We give here a detailed description of our experimental setup and of the procedures used to align its components. We then present experimental signals, exhibiting atomic interference effects with a very high visibility, up to 84.5 %. We describe a series of experiments testing the sensitivity of the fringe visibility to the main alignment defects and to the magnetic field gradient.Comment: 8 avril 200