Concept ‘frienship’ in researches

The article addresses the main features of the Russian concept “Friendship” revealed by analysis of researches devoted to it.В статье рассматриваются основные особенности русского концепта «Дружба», выявленные на основании анализа посвященных ему исследований

Readiness for using distance educational technologys as a condition of social and professional mobility of future teachers

The article considers the problem associated with the study of the phenomenon of socio-occupational mobility of the future teachers in terms of readiness to change the operational sphere of professional activity on the background of the development of modern technical means and information technology. One of the conditions of formation of socio-occupational mobility is the readiness to use the distance educational technologyРассматривается феномен социально-профессиональной мобильности будущих педагогов как готовности к оперативной смене сферы профессиональной деятельности на фоне развития современных технических средств и информационных технологий. Обозначено, что одним из условий формирования социально-профессиональной мобильности является использование дистанционных образовательных технологи

Remote educational technology in the network interaction

This article discusses the problem of the organization in the context of networking from a position of joint activities in the framework of e-learning and distance learning technologies. Presented with various approaches to the definition of «networking». Are some of the forms of implementation of distance learning technologies: video lecture, chat, webinar, consultation, etc.Рассмотрена проблема организации сетевого взаимодействия с позиции совместной деятельности в рамках электронного обучения и дистанционных образовательных технологий. Охарактеризованы различные подходы к определению сетевого взаимодействия, некоторые формы реализации дистанционных образовательных технологий (видеолекция, семинар, чат, вебинар, консультация и др.)

Spontaneous Reporting Method Used for Safety Evaluation of Nonsteroidal Anti-Inflammatory Drugs and Paracetamol Products, Based on Assessment of Data from Periodic Reports

High rates of adverse drug reactions (ADRs) associated with nonsteroidal anti-inflammatory drugs (NSAIDs), as well as their irrational and uncontrolled use for self-medication require continuous updating of information on safety profiles of these products.The aim of the study was to assess the reporting rate, frequency, and severity of ADRs to NSAIDs and paracetamol products, based on data from periodic safety update reports (PSURs) submitted to the autonomous non-profit organisation “National Pharmacovigilance Research Centre”.Materials and methods: the study covered 104 PSURs for NSAIDs and paracetamol products. Consumption levels were calculated in patient days (PTDs) and patient years (PTYs) for each international nonproprietary name (INN). The authors also analysed clinical manifestations and severity of ADRs.Results: the total number of PTDs and PTYs for all NSAIDs and paracetamol products, including combination medicines, was 1 963 750 485 PTDs or 5 380 138.3 PTYs, respectively. The PSURs reported 459 ADRs, of which 304 (66.2%) were serious ADRs (SADRs). The comparative analysis of ADR frequencies, expressed as the “ADR/PTY” ratio, for individual products, helped to identify INNs with the highest reporting rates.Conclusions: high ADR/PTY and SADR/PTY values indicating better ADR reporting for some INNs, were observed for piroxicam, paracetamol, dexketoprofen, and ketoprofen, while the lowest values were observed for the “acetyl salicylic acid+caffeine+paracetamol” combination, acetylsalicylic acid, and phenylbutazone. Thus, the comparison of ADR/PTY and SADR/PTY ratios can be recommended as an inclusive approach both for analysis of reporting trends for individual products and for comparison of reporting rates of different medicinal products

The use of information technology in education

В данной статье рассмотрены основные характеристики информационных технологий в образовании, а также достоинства и недостатки использования таких технологий.In this article, the authors discuss the main characteristics of information technology in education, as well as the advantages and disadvantages of the use of such technologies

Modern problems of development of education system, as a socio-economic component

Современное социально-экономическое развитие выдвигает ряд требований к системе образования.The current socio-economic development put forward a number of demands to the education system

Dynamics of health of students in the learning process

В статье рассматривается динамика работоспособности студентов вуза в зависимости от времени дня, недели, семестра, учебного года при разных уровнях учебной нагрузки.The article discusses the dynamics of health of students depending on the time of day, week, semester, academic year at different levels of workload

Peculiarities of Adverse Events Manifested by Injury of Skin and Skin Derivatives and Associated with Beta-blockers Use

More than 50 years after Propranolol was introduced to the pharmaceutical market as a drug that can lower the heart rate, beta-blockers (BAB) are still widely used in the pharmacotherapy of cardiovascular diseases. However, the use of BAB has a number of limitations, first of all, due to adverse drug events (AE) that develop during their use. The purpose of our review was to study the features of the BAB AE manifested by injuries of the skin and its appendages. The clinical manifestations of them are the development or exacerbation of psoriasis, lichen planus, contact dermatitis, acrocyanosis, Raynaud's disease, alopecia, hyperhidrosis, vitiligo, anaphylaxis, and allergic skin reactions. True medicinal psoriasis occurs in patients taking BAB with no family or previous history and most often mimics erythrodermic psoriasis and palmar-plantar pustular psoriasis. Systemic use of BAB can also be accompanied by exacerbation of vitiligo. In patients with segmental vitiligo, the results of Doppler flowmetry and iontophoresis showed increased blood flow in vitiligo foci compared with normal skin. The development of anaphylactic reactions against the background of BAB therapy may be due to the modulation of adenylate cyclase, which can affect the release of anaphylactogenic mediators, as well as a decrease in the severity of cardiovascular compensatory changes. The peculiarities of the development of such reactions may be the resistance of patients to traditional treatment, which is due to the development of paradoxical reflex vagotonic effects when using adrenaline. Some of the mentioned AE may pose a potential threat to the life and health of the patient and therefore require additional discussion

Problems of development of professional pedagogical education

В статье рассматриваются основные проблемы профессионально-педагогического образования.The article discusses the main problems of vocational teacher education

Check of knowleadge using score-rating system and independent test control

Анализируется проблема дублирования балльно-рейтинговой системы оценивания и независимого тестового контроля в системе подготовки специалистов. Предложены мероприятия по устранению недостатковIn article it is told about duplication of score-rating system and independent test controlin training system of specialists. Actions for elimination of shortcomingsare offere