10 research outputs found
Large bilateral adrenal metastases in non-small cell lung cancer
BACKGROUND: The adrenal gland is one of the common sites of metastasis from primary lung cancer. Adrenal metastases are usually unilateral however bilateral adrenal metastases are seen in 10% of all lung cancer patients; of these 2–3% occurs at the initial presentation of non-small cell lung cancer. Secondary tumors can disrupt the structure and function of the adrenal. This can lead to adrenal hemorrhage, which constitutes a life threatening hazard for the patient. CASE PRESENTATION: A 59-year-old male presented with persisting abdominal pain. His initial work-up revealed significant anemia, an invasive process in the right upper lobe of the lung and large masses of heterogeneous texture, with hemorrhagic and necrotic elements in both adrenal glands. A biopsy confirmed it to be a large-cell carcinoma of the lungs. The patient developed severe leukocytosis akin to the paraneoplastic syndrome and died suddenly five days after the administration of chemotherapy. CONCLUSION: Intratumoral hemorrhage is a rare but life threatening complication of adrenal metastases and should be treated as soon as it has been diagnosed. If adrenalectomy is not feasible, combination chemotherapy should be applied as in metastatic disease. For choosing the appropriate chemotherapeutic regimen it is important to accurately achieve the diagnosis
Paraneoplastic limbic encephalitis as a cause of new onset of seizures in a patient with non-small cell lung carcinoma: a case report
Post-laparoscopic cholecystectomy Mirizzi syndrome induced by polymeric surgical clips: a case report and review of the literature
Systems and control problems in early systems design
EThOS - Electronic Theses Online ServiceGBUnited Kingdo
Design of high efficiency RF power amplifier based on the Doherty technique
International audienc
A Multi-objective approach to Subarrayed Linear Antenna Arrays Design
Abstract In this paper we present a multi-objective optimization approach to subarrayed linear antenna arrays design. We define this problem as a bi-objective one. We consider two objective functions for directivity maximization and sidelobe level minimization. Two popular Multi-Objective Evolutionary Algorithms (MOEAs), the Generalized Differential Evolution (GDE3) and the Nondominated Sorting Genetic Algorithm-II (NSGA-II), are employed in this study. GDE3 and NSGA-II are applied to the synthesis of uniform and nonuniform subarrayed linear arrays, providing an extensive set of solutions for each design case. Depending on the desired array characteristics, the designer can select the most suitable solution. The results of the proposed method are compared with those reported in the literature, indicating the advantages and applicability of the multi-objective approach
Hiatal hernia predisposes to nocturnal gastro-oesophageal reflux
Background: Nocturnal reflux has been associated with severe
complications of gastro-oesophageal reflux disease and a poorer quality
of life. Hiatal hernia predisposes to increased oesophageal acid
exposure, but the effect on night reflux symptoms has never been
investigated. The aim of the study was to investigate if hiatal hernia
is associated with more frequent and severe night reflux symptoms.
Methods: A total of 215 consecutive patients (110 male, mean age 52.6
+/- 14.7 years) answered a detailed questionnaire on frequency and
severity of specific day and night reflux symptoms. Subsequently, all
patients underwent upper endoscopy and were categorized in two groups
based on the endoscopic presence of hiatal hernia.
Results: Patients with hiatal hernia were more likely to have nocturnal
symptoms compared to those without hiatal hernia (78.6 vs. 51.8%, p =
0.0001); 59.2% of patients with hiatal hernia reported heartburn and
60.2% regurgitation compared to 43.8 and 39.3% of those without hiatal
hernia, respectively (p = 0.033 and p = 0.003). The proportions of
patients with day heartburn or regurgitation were not significantly
different between the two groups. Night heartburn and regurgitation were
graded as significantly more severe by patients with hiatal hernia (4.9
+/- 4.2 vs. 3.2 +/- 3.7, p +/- 0.002, and 3.8 +/- 4.2 vs. 2.2 +/- 3.5, p
= 0.001, respectively). Patients with hiatal hernia had more frequent
weekly night heartburn and regurgitation compared to those without
hiatal hernia (p = 0.004 and p = 0.008, respectively).
Conclusions: More patients with hiatal hernia reported nocturnal reflux
symptoms compared to those without hiatal hernia. Furthermore, nocturnal
reflux symptoms were significantly more frequent and graded as
significantly more severe in patients with presence of hiatal hernia
rather than in those without hiatal hernia
Eradication of Infection Restores ki67, p53, and Cyclin D1 Immunoreactivity in the Human Gastric Epithelium
Introduction We evaluated the effect of Helicobacter pylori (HP) eradication on p53, cyclin D1 expression, and cell proliferation in gastric mucosa. Materials and Methods We assessed p53, cyclin D1, and ki67 immunoexpression in gastric mucosa from 31 HP chronic gastritis patients and 12 controls. Reassessment was performed 6 months after successful HP eradication. Results Successful eradication resulted in significant decrease of p53 (1.53 ± 0.16 vs 0.83 ± 0.19, P = 0.01) and ki67 (9.84 ± 0.96 vs 4.77 ± 0.27, P < 0.001) staining in the antrum. Similarly, p53 immunoreactivity significantly decreased in the corpus (1.27 ± 0.20 vs 0.46 ± 0.15, P = 0.02), while there was a trend for decreased corpus cyclin D1 and ki67 expression (0.17 ± 0.07 vs 0.0, P = 0.08 and 8.71 ± 1.24 vs 5.85 ± 0.54, P = 0.09, respectively). Importantly, after successful HP eradication, the immunoreactivity of the studied parameters was similar to that of controls. Conclusion Successful HP infection eradication restores p53, cyclin D1, and ki67 immunoreactivity in the gastric mucosa to the level of controls