27 research outputs found
Central Serous Chorioretinopathy after Rhinoplasty
We report a case of central serous chorioretinopathy after rhinoplasty for deviation of the nasal septum in a 23-year-old Caucasian man. The patient complained of deterioration of vision in the right eye 4 days after rhinoplasty. At presentation, visual acuity of the right eye was 6/9 with metamorphopsia. Fluorescein angiography revealed a focal retinal pigment epithelium leakage and optical coherence tomography an increase in macular thickness to 245 μm. The left eye was normal. One month after the operation, without any treatment, visual acuity returned to 6/6, the leakage of the retinal pigment epithelium disappeared and the macular thickness returned to 183 μm. To the best of our knowledge, central serous chorioretinopathy after rhinoplasty has not been previously reported. This case report shows a possible association between the postoperative stress and central serous chorioretinopathy. Moreover, it widens the spectrum of drugs associated with the occurrence of the disease
Corneal Clarity and Visual Outcomes after Small-Incision Lenticule Extraction and Comparison to Femtosecond Laser-Assisted In Situ Keratomileusis
Purpose. To evaluate corneal clarity and visual outcomes after small-incision lenticule extraction (SMILE) and compare them to femtosecond laser-assisted in situ keratomileusis (FS-LASIK). Materials and Methods. Fifty-eight myopic eyes of 33 patients who underwent SMILE were compared to 58 eyes of 33 patients treated with FS-LASIK. All procedures were performed using VisuMax® femtosecond laser and MEL 80® excimer laser (Carl Zeiss Meditec AG, Germany). Pentacam™ (Oculus, Germany) was used for pre- and 3-month postoperative corneal densitometry (CD) analysis. CD was evaluated at 3 optically relevant, concentric radial zones (0–2 mm, 2–6 mm, and 0–6 mm annulus) around the corneal apex and at 3 different anatomical corneal layers (anterior, central, and posterior). Associations of postoperative CD values with the lenticule thickness and ablation depth were examined. Preoperative and postoperative corrected distance visual acuity (CDVA) values were also compared. Results. After SMILE, the total CD (all corneal layers) at 0–6 mm annulus showed no significant change compared to preoperative values (P=0.259). After FS-LASIK, the total CD was significantly reduced (P=0.033). Three-month postoperative CD showed no significant differences between the 2 groups for all examined annuli (0–2 mm: P=0.569; 2–6 mm: P=0.055; and 0–6 mm: P=0.686). Total CD after SMILE at 0–6 mm annulus displayed a weak negative association with the lenticule thickness (P=0.079, R2=0.0532) and after FS-LASIK displayed a weak negative association with the ablation depth (P=0.731, R2=0.0015). Postoperative CDVA was similar for both groups (P=0.517). Conclusion. Quantification of corneal clarity using the Scheimpflug CD showed similar results before and 3 months after SMILE. Compared to FS-LASIK, no significant differences of corneal clarity and CDVA were found 3 months postoperatively
Mutations in FRMD7, a newly identified member of the FERM family, cause X-linked idiopathic congenital nystagmus.
Idiopathic congenital nystagmus is characterized by involuntary, periodic, predominantly horizontal oscillations of both eyes. We identified 22 mutations in FRMD7 in 26 families with X-linked idiopathic congenital nystagmus. Screening of 42 singleton cases of idiopathic congenital nystagmus (28 male, 14 females) yielded three mutations (7%). We found restricted expression of FRMD7 in human embryonic brain and developing neural retina, suggesting a specific role in the control of eye movement and gaze stability
Mutations in FRMD7, a newly identified member of the FERM family, cause X-linked idiopathic congenital nystagmus
Idiopathic congenital nystagmus (ICN) is characterised by involuntary, periodic, predominantly horizontal, oscillations of both eyes. We identified 22 mutations in FRMD7 in 26 families with X-linked idiopathic congenital nystagmus. Screening of 42 ICN singleton cases (28 male, 14 females) yielded three mutations (7%). We found restricted expression of FRMD7 in human embryonic brain and developing neural retina suggesting a specific role in the control of eye movement and gaze stability
Posttraumatic Sphingomonas paucimobilis Endophthalmitis
A rare case of Sphingomonas paucimobilis endophthalmitis secondary to a penetrating globe injury with a retained intraocular foreign body is presented. A 30-year-old man presented with severe pain following a penetrating left eye injury. Visual acuity (VA) was 6/120. Slit-lamp examination revealed perforation of the temporal cornea and iris, hypopyon, and a fibrinous membrane covering the pupil. Ultrasonography showed dense vitreous infiltration and an orbital CT-scan confirmed the presence of a metallic foreign body in the vitreous cavity. Topical and systemic therapy were initiated. Pars-plana vitrectomy combined with phacoemulsification was performed in order to remove the foreign body; vitreous samples were acquired and Sphingomonas paucimobilis, sensitive to ceftazidime, was identified. To the best of our knowledge, this is the first report of Sphingomonas paucimobilis endophthalmitis following penetrating ocular injury. In this case, Sphingomonas paucimobilis was not resistant to antibiotics. This allowed for a good healing response following vitrectomy despite the fact that long-term retinal complications resulted in low VA
Conjunctival naevus regression during adolescence; a case report
Purpose To report a case of spontaneous regression of a conjunctival naevus in an adolescent patient.
Methods Rare case presentation
Case presentation Conjunctival naevi represent the most common melanocytic lesions affecting the ocular surface. They are benign conjunctival tumours that usually remain stable, or progressively increase in size and pigmentation. We describe a rare case of a 15-year-old female patient presenting with a conjunctival melanocytic naevus that underwent spontaneous regression over a 2-year-follow up period.
Conclusion Although regression of a conjunctival naevus is an uncommon phenomenon, this potential should be taken into consideration during the decision-making process, when selecting between observation and cosmetic surgical excision for their management.</p
Scheimpflug Densitometry After DMEK Versus DSAEKTwo-Year Outcomes
Purpose:To compare the course of Scheimpflug corneal densitometry (CD)
after Descemet membrane endothelial keratoplasty (DMEK) versus Descemet
stripping automated endothelial keratoplasty (DSAEK).Methods:Fifty-four
DMEK and 25 DSAEK cases without previous corneal surgery, complicated
intraoperative or postoperative course, or vision-limiting ocular
comorbidities were included. Pseudophakic eyes of age-matched subjects
were recruited as controls (n = 20). Scheimpflug CD of the optically
relevant zones (0-2 and 2-6 mm), best-corrected visual acuity (BCVA),
endothelial cell density, and central corneal thickness were evaluated
preoperatively and at 3, 6, 12, and 24 months postoperatively.Results:CD
of the optical zone decreased from 34.4 9.4 grayscale units (GSU) before
to 19.2 +/- 2.7 GSU at 24 months after DMEK. Respectively, CD decreased
from 34.0 +/- 13.4 GSU before to 21.2 +/- 2.5 GSU at 24 months after
DSAEK. Mean central CD in group 3 was 18.1 +/- 1.3 GSU. Compared with
DSAEK, DMEK cases showed lower central CD at 3 and 6 months (P 0.012)
but not at 12 and 24 months postoperatively. DSAEK showed higher CD
values throughout the postoperative period compared with healthy
controls (P < 0.001). DMEK showed higher CD compared with controls at 3,
6, and 12 but not at 24 months after surgery (P = 0.152). Postoperative
BCVA was significantly better after DMEK for every examination time
point. No difference in endothelial cell density was found between DMEK
and DSAEK at any time point.Conclusions:DMEK showed lower CD and better
BCVA compared with DSAEK in the first 6 postoperative months. Notably,
although CD reached similar levels in the midterm after both DMEK and
DSAEK, BCVA remained significantly better after DMEK
Secondary DMEK following failed primary DMEK
Purpose To report the outcomes of secondary Descemet Membrane
Endothelial Keratoplasty (DMEK) performed for failed primary DMEK.
Methods The medical records of all patients undergoing secondary DMEK
due to failure of primary DMEK were reviewed. Reasons for failure were
sought and best-corrected visual acuity (BCVA), endothelial cell density
(ECD) and complications of secondary DMEK were evaluated. Results A
total of 10 cases undergoing secondary DMEK following failed primary
DMEK were identified. Presumed reasons for failure included donor ECD <=
2300 cells/mm(2) (n = 4), difficulty during graft preparation (n = 2),
graft detachment (n = 2), acute angle closure due to retroiridal air
dislocation (n = 1), inverse graft positioning (n = 1) and
phacoemulsification (n = 1). Eyes with low visual potential were not
excluded from the study group. We should note that one patient (case
no7) had both low ECD and graft detachment as reasons for failure and as
a result he is counted twice. Median BCVA (decimal fraction) increased
from 0.1 (range, 0.01; 0.3) to 0.5 (0.05; 1.0) at one month and remained
stable thereafter. A BCVA of 0.5 or higher was achieved in 7 cases at
the final follow-up. Mean ECD fell from 2628 +/- 284 cells/mm(2) to 1391
+/- 252cells/mm(2) at 6 months (47% reduction) and 959 +/-
225cells/mm(2) at 24 months (64% reduction) (P <= 0.028). Complications
included the incomplete removal of the primary graft and mild iris
bleeding, decompensation of a preexisting primary open-angle glaucoma
and retroiridal air dislocation. Conclusions Apart from low donor ECD,
surgical challenges, i.e., difficulty with graft preparation, inverse
graft positioning, and retroiridal air dislocation, were main reasons
for failure of primary DMEK. Secondary DMEK showed a good safety profile
and reasonable visual outcomes