Paralytic ileus as the first presentation in type A acute aortic dissection

A 78-year-old female was referred to our hospital with a diagnosis of type A acute aortic dissection. There was a history of thrombosed aortic dissection six months prior and conservative management has been performed. Enhanced computed tomography showed type A acute aortic dissection with patent false lumen limited to the ascending aorta and ileus of the small intestine. Emergency hemiarch replacement was performed under mild hypothermic circulatory arrest and selective antegrade cerebral perfusion. Due to preoperative paralytic ileus, oral intake was initiated postoperative day four. Postoperative computed tomography revealed improvement of paralytic ileus

『現代日本語書き言葉均衡コーパス』の文境界修正

国立国語研究所 コーパス開発センター 非常勤研究員マンパワーグループ株式会社国立国語研究所 理論・構造研究系 非常勤研究員国立国語研究所 コーパス開発センター 非常勤研究員国立国語研究所 言語資源研究系国立国語研究所 コーパス開発センター 技術補佐員(元)国立国語研究所 コーパス開発センター プロジェクト研究員文部科学省国立国語研究所 言語資源研究系国立国語研究所 言語資源研究系国立国語研究所 言語資源研究系国立国語研究所 言語資源研究系国立国語研究所 言語資源研究系Adjunct Researcher, Center for Corpus Development, NINJALManpower Group Co., LtdAdjunct Researcher, Department of Linguistic Theory and Structure, NINJALAdjunct Researcher, Center for Corpus Development, NINJALDepartment of Corpus Studies, NINJAL(former) Technical Staff, Center for Corpus Development, NINJALPostdoctoral Research Fellow, Center for Corpus Development, NINJALMinistry of Education, Culture, Sports, Science, and TechnologyDepartment of Corpus Studies, NINJALDepartment of Corpus Studies, NINJALDepartment of Corpus Studies, NINJALDepartment of Corpus Studies, NINJALDepartment of Corpus Studies, NINJAL『現代日本語書き言葉均衡コーパス』第1.0版(Maekawa et al. 2014)(以下BCCWJ)には「文境界」の情報がアノテーションされているが,その認定基準の妥当性について従来から様々な指摘がある(小西ほか2014,長谷川2014,田野村2014)。この問題に対処するために,国立国語研究所コーパス開発センターでは2013年から2014年にかけて,BCCWJの修正を行った。本稿ではその修正作業について報告する。第1.0版におけるBCCWJ 文境界情報の問題は,コーパス構築の過程において文境界を含む文書構造タグの整備と形態素列レベルの情報の整備とを並行して行ったために,文字情報を用いる文境界処理にとどまったことに由来する。今回,形態論情報に基づいた文境界基準を策定し,問題の解消を試みた。文境界修正の指針を示すとともに,文境界修正に用いた作業環境と,修正件数について報告する。In December 2011, the National Institute for Japanese Language and Linguistics (NINJAL) released a 100-million-word balanced corpus - the Balanced Corpus of Contemporary Written Japanese (BCCWJ) DVD Version 1.0 - which was compiled from 2006 through 2011. Some users have pointed out some issues concerning sentence delimitation in the BCCWJ. To address these issues, we - NINJAL - performed a complete survey and correction, beginning in 2013 and ending in 2014. This article reports the revision work on sentence delimitation in the BCCWJ. The problems with the BCCWJ DVD Version 1.0 derive from the string-based definition. We could not obtain any morpheme information for the sentence delimitation task because of the task parallelism between sentence delimitation annotation and morpheme annotation. The method used this time was morpheme based. We present the morpheme-based annotation guidelines, annotation environment, and basic statistics of the corpus correction

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

「コロナ制圧タスクフォース」COVID-19患者由来の血液細胞における遺伝子発現の網羅的解析 --重症度に応じた遺伝子発現の変化には、ヒトゲノム配列の個人差が影響する--. 京都大学プレスリリース. 2022-08-23.Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection

DOCK2 is involved in the host genetics and biology of severe COVID-19

「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target

マイクロサテライト マーカー ノ カイハツ ト サイバイ ソバ ノ キゲン ニ カンスル ケンキュウ エノ オウヨウ

京都大学0048新制・課程博士博士(農学)甲第11990号農博第1534号新制||農||922(附属図書館)学位論文||H18||N4103(農学部図書室)23803UT51-2006-C670京都大学大学院農学研究科応用生物科学専攻(主査)教授 大西 近江, 教授 遠藤 隆, 教授 谷坂 隆俊学位規則第4条第1項該当Doctor of Agricultural ScienceKyoto UniversityDA