Effect of mouse submandibular gland extracts on survival of H-2 incompatible skin allografts

Crude saline extracts of male mouse submandibular glands prolonged graft survival time in CBA and Strong A strains of mice, both when used alone and when used in conjunction with antithymocytic serum. It is suggested that this effect is produced by a lymphoid tissue inhibitory substance found in male mouse submandibular glands

Characteristics of Mononuclear Phagocytes Mediating Antilisterial Resistance in Splenectomized Mice

The characteristics of mononuclear phagocytes mediating resistance to infection with Listeria monocytogenes during the early phase (up to 48 h) of the response were investigated in mice of the A strain that had undergone splenectomy. Although irradiation in the sham-operated host had no effect on its antilisterial response when administered immediately before infection, it markedly reduced the ability of the splenectomized host to resist listerial challenge. This effect of radiation was demonstrable in the high-dose range (600 r) and could not be reversed immediately by repopulation with 20 × 10(6) syngeneic nucleated bone marrow cells. Administration of silica 24 h before infection profoundly enhanced the growth of L. monocytogenes in the liver of splenectomized mice. Shielding of the liver, but not the bone marrow, protected the splenectomized host against the effects of radiation, indicating that the cell population responsible for mediating the enhanced antilisterial resistance resides in the liver. The enhanced antilisterial resistance of splenectomized mice was specifically because of the absence of the spleen and not merely because of the removal of a favorable replicating environment for listeria organisms

A BALB/c Congenic Strain of Mice That Carries a Genetic Locus (Ity\u3csup\u3er\u3c/sup\u3e) Controlling Resistance to Intracellular Parasites

BALB/c.DBA/2 Idh-1b-Ityr-Pep-3b congenic mice were developed by introgressively backcrossing the Idh-1b and Pep-3b markers of DBA/2 mice onto the BALB/cπ mice. This introduced a 30-centimorgan chromosome 1 segment of DBA/2 chromatin that contained the Ityr gene. BALB/c.DBA/2 Idh-1b-Ityr-Pep-3b mice were resistant to in vivo infections by Salmonella typhimurium, Mycobacterium bovis, and Leishmania donovani