Interaction of the westerlies with the Tibetan Plateau in determining the Mei-Yu termination

This study explores how the termination of the mei-yu is dynamically linked to the westerlies impinging on the Tibetan Plateau. It is found that the mei-yu stage terminates when the maximum upper-tropospheric westerlies shift beyond the northern edge of the plateau, around 408N. This termination is accompanied by the disappearance of tropospheric northerlies over northeastern China. The link between the transit of the jet axis across the northern edge of the plateau, the disappearance of northerlies, and termination of the mei-yu holds on a range of time scales from interannual through seasonal and pentad. Diagnostic analysis indicates that the weakening of the meridional moisture contrast and meridional wind convergence, mainly resulting from the disappearance of northerlies, causes the demise of the mei-yu front. The authors propose that the westerlies migrating north of the plateau and consequent weakening of the extratropical northerlies triggers the mei-yu termination. Model simulations are employed to test the causality between the jet and the orographic downstream northerlies by repositioning the northern edge of the plateau. As the plateau edge extends northward, orographic forcing on the westerlies strengthens, leading to persistent strong downstream northerlies and a prolonged mei-yu. Idealized simulations with a dry dynamical core further demonstrate the dynamical link between the weakening of orographically forced downstream northerlies with the positioning of the jet from south to north of the plateau. Changes in the magnitude of orographically forced stationary waves are proposed to explain why the downstream northerlies disappear when the jet axis migrates beyond the northern edge of the plateau

The cytoskeleton in cell-autonomous immunity: structural determinants of host defence

Host cells use antimicrobial proteins, pathogen-restrictive compartmentalization and cell death in their defence against intracellular pathogens. Recent work has revealed that four components of the cytoskeleton — actin, microtubules, intermediate filaments and septins, which are well known for their roles in cell division, shape and movement — have important functions in innate immunity and cellular self-defence. Investigations using cellular and animal models have shown that these cytoskeletal proteins are crucial for sensing bacteria and for mobilizing effector mechanisms to eliminate them. In this Review, we highlight the emerging roles of the cytoskeleton as a structural determinant of cell-autonomous host defence

Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.

Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery. Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period. The primary outcome was the rate of AKI within 7 days of surgery. Bootstrap stability was used to select clinically plausible risk factors into the model. Internal model validation was carried out by bootstrap validation. Results: A total of 4544 patients were included across 173 centres in the UK and Ireland. The overall rate of AKI was 14·2 per cent (646 of 4544) and the 30-day mortality rate was 1·8 per cent (84 of 4544). Stage 1 AKI was significantly associated with 30-day mortality (unadjusted odds ratio 7·61, 95 per cent c.i. 4·49 to 12·90; P < 0·001), with increasing odds of death with each AKI stage. Six variables were selected for inclusion in the prognostic model: age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker. Internal validation demonstrated good model discrimination (c-statistic 0·65). Discussion: Following major gastrointestinal surgery, AKI occurred in one in seven patients. This preoperative prognostic model identified patients at high risk of postoperative AKI. Validation in an independent data set is required to ensure generalizability

Southward Shift of Westerlies Intensifies the East Asian Early Summer Rainband Following El Niño

An intensification of East Asian rainfall usually occurs in summers following El Niño. We propose that this teleconnection is mediated via the westerlies impinging on the Tibetan Plateau, through El Niño's control on tropical tropospheric temperature. This is distinct from previous studies that attribute the El Niño's influence to changes in the western Pacific subtropical anticyclone. The warming in the eastern equatorial Pacific leads to uniform warming of the entire tropical troposphere, which sharpens the temperature gradient between the tropics and the subtropics and shifts the westerlies southward. The westerlies impinge over the Tibetan Plateau for longer and, through interaction with the topography, induce intense and persistent extratropical northerlies downstream of the plateau that in turn intensifies the East Asian rainband. The rainband has previously been shown to intensify in a similar manner in a warming climate, suggesting that the El Niño response provides an analog for future changes

Southward Shift of Westerlies Intensifies the East Asian Early Summer Rainband Following El Niño

An intensification of East Asian rainfall usually occurs in summers following El Niño. We propose that this teleconnection is mediated via the westerlies impinging on the Tibetan Plateau, through El Niño's control on tropical tropospheric temperature. This is distinct from previous studies that attribute the El Niño's influence to changes in the western Pacific subtropical anticyclone. The warming in the eastern equatorial Pacific leads to uniform warming of the entire tropical troposphere, which sharpens the temperature gradient between the tropics and the subtropics and shifts the westerlies southward. The westerlies impinge over the Tibetan Plateau for longer and, through interaction with the topography, induce intense and persistent extratropical northerlies downstream of the plateau that in turn intensifies the East Asian rainband. The rainband has previously been shown to intensify in a similar manner in a warming climate, suggesting that the El Niño response provides an analog for future changes

Interaction of the westerlies with the Tibetan Plateau in determining the Mei-Yu termination

This study explores how the termination of the mei-yu is dynamically linked to the westerlies impinging on the Tibetan Plateau. It is found that the mei-yu stage terminates when the maximum upper-tropospheric westerlies shift beyond the northern edge of the plateau, around 408N. This termination is accompanied by the disappearance of tropospheric northerlies over northeastern China. The link between the transit of the jet axis across the northern edge of the plateau, the disappearance of northerlies, and termination of the mei-yu holds on a range of time scales from interannual through seasonal and pentad. Diagnostic analysis indicates that the weakening of the meridional moisture contrast and meridional wind convergence, mainly resulting from the disappearance of northerlies, causes the demise of the mei-yu front. The authors propose that the westerlies migrating north of the plateau and consequent weakening of the extratropical northerlies triggers the mei-yu termination. Model simulations are employed to test the causality between the jet and the orographic downstream northerlies by repositioning the northern edge of the plateau. As the plateau edge extends northward, orographic forcing on the westerlies strengthens, leading to persistent strong downstream northerlies and a prolonged mei-yu. Idealized simulations with a dry dynamical core further demonstrate the dynamical link between the weakening of orographically forced downstream northerlies with the positioning of the jet from south to north of the plateau. Changes in the magnitude of orographically forced stationary waves are proposed to explain why the downstream northerlies disappear when the jet axis migrates beyond the northern edge of the plateau

Seasonal transitions and the westerly jet in the Holocene East Asian summer monsoon

The Holocene East Asian summer monsoon (EASM) was previously characterized as a trend toward weaker monsoon intensity paced by orbital insolation. It is demonstrated here that this evolution is more accurately characterized as changes in the transition timing and duration of the EASM seasonal stages (spring, pre-mei-yu, mei-yu, midsummer), and tied to the north-south displacement of the westerlies relative to Tibet. To this end, time-slice simulations across the Holocene are employed using an atmospheric general circulation model. Self-organizing maps are used to objectively identify the transition timing and duration of the EASM seasonal stages. Compared to the late Holocene, an earlier onset of mei-yu and an earlier transition from mei-yu to midsummer in the early to mid-Holocene are found, resulting in a shortened mei-yu and prolonged midsummer stage. These changes are accompanied by an earlier northward positioning of the westerlies relative to Tibet. Invoking changes to seasonal transitions also provides a more satisfactory explanation for two key observations of Holocene East Asian climate: the "asynchronous Holocene optimum" and changes to dust emissions. A mechanism is proposed to explain the altered EASM seasonality in the simulated early to mid-Holocene. The insolation increase over the boreal summer reduces the pole-equator temperature gradient, leading to northward-shifted and weakened westerlies. The meridional position of the westerlies relative to the Tibetan Plateau determines the onset of mei-yu and possibly the onset of the midsummer stage. The northward shift in the westerlies triggers earlier seasonal rainfall transitions and, in particular, a shorter mei-yu and longer midsummer stage

Role of seasonal transitions and the westerlies in the interannual variability of the East Asian summer monsoon precipitation

A recent hypothesis holds that changes to the East Asian summer rainfall are characterized by changes in the timing and duration of its intraseasonal stages, controlled by the meridional position of the westerlies relative to the Tibetan Plateau. This hypothesis is examined in the context of the leading mode of East Asian summer (July–August) rainfall. One phase of this “tripole” mode—characterized by less rainfall over central eastern China and increased rainfall over northeastern and southeastern China—is tied to an earlier termination of Meiyu that results in a significantly shorter Meiyu and longer Midsummer stage. This phase also exhibits an earlier northward transition of the westerlies to the north of the Plateau, essentially mirroring the changes to precipitation seasonality. The reverse does not hold true for the opposite phase. Our results show direct observational evidence for the meridional position of the westerlies to control East Asian summer monsoon seasonality

Role of seasonal transitions and the westerlies in the interannual variability of the East Asian summer monsoon precipitation

A recent hypothesis holds that changes to the East Asian summer rainfall are characterized by changes in the timing and duration of its intraseasonal stages, controlled by the meridional position of the westerlies relative to the Tibetan Plateau. This hypothesis is examined in the context of the leading mode of East Asian summer (July–August) rainfall. One phase of this “tripole” mode—characterized by less rainfall over central eastern China and increased rainfall over northeastern and southeastern China—is tied to an earlier termination of Meiyu that results in a significantly shorter Meiyu and longer Midsummer stage. This phase also exhibits an earlier northward transition of the westerlies to the north of the Plateau, essentially mirroring the changes to precipitation seasonality. The reverse does not hold true for the opposite phase. Our results show direct observational evidence for the meridional position of the westerlies to control East Asian summer monsoon seasonality

Origins of east asian summer monsoon seasonality

The East Asian summer monsoon is unique among summer monsoon systems in its complex seasonality, exhibiting distinct intraseasonal stages. Previous studies have alluded to the downstream influence of the westerlies flowing around the Tibetan Plateau as key to its existence. We explore this hypothesis using an atmospheric general circulation model that simulates the intraseasonal stages with fidelity. Without a Tibetan Plateau, East Asia exhibits only one primary convective stage typical of other monsoons. As the plateau is introduced, the distinct rainfall stages—spring, pre-mei-yu, mei-yu, and midsummer—emerge, and rainfall becomes more intense overall. This emergence coincides with a pronounced modulation of the westerlies around the plateau and extratropical northerlies penetrating northeastern China. The northerlies meridionally constrain the moist southerly flow originating from the tropics, leading to a band of lower-tropospheric convergence and humidity front that produces the rainband. The northward migration of the westerlies away from the northern edge of the plateau leads to a weakening of the extratropical northerlies, which, coupled with stronger monsoonal southerlies, leads to the northward migration of the rainband. When the peak westerlies migrate north of the plateau during the midsummer stage, the extratropical northerlies disappear, leaving only the monsoon low-level circulation that penetrates northeastern China; the rainband disappears, leaving isolated convective rainfall over northeastern China. In short, East Asian rainfall seasonality results from the interaction of two seasonally evolving circulations—the monsoonal southerlies that strengthen and extend northward, and the midlatitude northerlies that weaken and eventually disappear—as summer progresses